Dennis Eshima

Comparison of Tc-99m MAG3 and Tc-99m DTPA in renal transplant patients with impaired renal function.

Tc-99m mercaptoacetyltriglycine (MAG3) is a new Tc-99m renal agent that compares favorably to I-131 Hippuran in animal models, normal volunteers, and patients. Based on the fact that Tc-99m MAG3 has a much more rapid clearance than Tc-99m DTPA and a smaller volume of distribution, it was postulated that the image quality of Tc-99m MAG3 studies should be superior to scans obtained using Tc-99m DTPA, particularly in patients with impaired renal function. To test this hypothesis, Tc-99m DTPA and MAG3 images were obtained in three transplant patients during periods of stable but impaired renal function. In one study, the Tc-99m DTPA study was potentially misleading, whereas the Tc-99m MAG3 examination assessed the clinical situation correctly. In all three cases, the Tc-99m MAG3 images were superior.

Iodophenylsulfonamide fatty acid analogs as potential myocardial imaging agents.

Abstract Two phenylsulfonamide fatty acid analogs were synthesized and radioiodinated as potential myocardial imaging agents that might be taken up in the cells and metabolically trapped. The acids, N -11-( p -iodophenylsulfonamide)-undecanoic acid and N -12-( p -iodophenylsulfonamide)-dodecanoic acid, were radioiodinated by exchange with cupric sulfate catalysis. Tissue distribution studies of the radioiodinated acids were performed in mice. Negligible myocardial uptake and rapid renal excretion of the radio-activity was observed with both compounds. The results suggest that the sulfonamide group perturbs the fatty acids to the extent that myocardial uptake is prevented.

Preliminary Results Comparing OIH, 99mTc-MAG3 and Iothalamate in a Rat Model of Renal Ischemia

We studied the effects of ischemic injury on the renal clearances of 131 I-iodohippurate 99m Tc-mercaptoacetylgtriglycerine and 125 I-iothalamate in an animal model