Dennis Mitsugu Yasuda

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Featured researches published by Dennis Mitsugu Yasuda.

MedChemComm | 2010

Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

Joshua Kennedy-Smith; Nidhi Arora; J. Roland Billedeau; Jennifer Fretland; Julie Q. Hang; Gabrielle Heilek; Seth F. Harris; Donald Roy Hirschfeld; Hassan Javanbakht; Yu Li; Weiling Liang; Ralf Roetz; Mark Smith; Guoping Su; Judy M. Suh; Armando G. Villaseñor; Jeffrey Wu; Dennis Mitsugu Yasuda; Klaus Klumpp; Zachary Kevin Sweeney

New pyridone non-nucleoside reverse transcriptase inhibitors (NNRTIs) were prepared and several flexible routes to this class of inhibitor were identified. These NNRTIs were active inhibitors of the replication of wild-type and NNRTI-resistant HIV. Structure-based drug design was used to optimize the activity of the compounds against NNRTI-resistant mutants. The co-crystal structure of inhibitor 2b in the NNRTI binding pocket of HIV reverse transcriptase (HIVRT) is also described.

Archive | 2006

P38 map kinase inhibitors and methods for using the same

Nidhi Arora; Humberto Bartolome Arzeno; Roland Joseph Billedeau; Nolan James Dewdney; Kieran Durkin; Tobias Gabriel; Kristen Lynn Mccaleb; Michael Soth; Dennis Mitsugu Yasuda

Archive | 1999

2-imidazoline, 2-oxazoline, 2-thiazoline, and 4-imidazole derivatives of methylphenyl, methoxphenyl, and aminophenyl alkylsulfonamides and ureas and their use

Richard Leo Cournoyer; Paul Francis Keitz; Counde O'yang; Dennis Mitsugu Yasuda

Archive | 2001

Carboxylic acid derivatives as IP antagonists

Richard Leo Cournoyer; Paul Francis Keitz; Lee Edwin Lowrie; Alexander Victor Muehldorf; Counde O'yang; Dennis Mitsugu Yasuda

Archive | 1998

Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists

Richard Leo Cournoyer; Paul Francis Keitz; Counde O'yang; Dennis Mitsugu Yasuda

Archive | 1998

N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists

Richard Leo Cournoyer; Paul Francis Keitz; Counde O'yang; Dennis Mitsugu Yasuda

Archive | 2009

N-[3-BROMO-2-CHLORO-4-(4, 5-DIHYDRO-1H-IMIDAZOL-2-YLMETHYL)-PHENYL] -METHANESULFOAMIDE AS ALPHA-1 A ADRENERGIC PARTIAL AGONIST FOR THE TREATMENT OF INCONTINENCE

Counde O'yang; Dennis Mitsugu Yasuda

Archive | 2007

Heterocyclische modulatoren für den gaba-alpha-subtyp-selektiven rezeptor Heterocyclic modulators for the gaba-alpha-subtype-selective receptor

Xiao-Fa Lin; David G. Loughhead; Jason Manka; Counde O'yang; Michael Soth; Dennis Mitsugu Yasuda

Archive | 2006

Inhibitoren der p38-map-kinase und verfahren zu deren anwendung

Nidhi Arora; Humberto Bartolome Arzeno; Roland Joseph Billedeau; Nolan James Dewdney; Kieran Durkin; Tobias Gabriel; Kristen Lynn Mccaleb; Michael Soth; Dennis Mitsugu Yasuda

Archive | 2004