Dennis Paul Phillion

Synthesis and reactivity of diethyl phosphonomethyltriflate

Abstract Diethyl phosphonomethyltriflate, prepared from diethyl hydroxymethyl—phosphonate, readily reacts in good to excellent yields with a variety of oxygen and nitrogen nucleophiles.

Synthesis & characterization of N-amino-glyphosate as a potent analog inhibitor of E. coli EPSP synthase

Abstract All previous attempts to identify glyphosate analogs which retain their potency against the known biological target, EPSP synthase, have been unsuccessful. Consequently, the glyphosate binding site was thought to be extremely specific in this system. Here we report the novel N-amino glyphosate analog 3 as the first successful modification of the glyphosate skeleton which exhibits inhibitor properties comparable to glyphosate.

A New Method for Hydrolyzing 2-Aryl-4,4-Dimethyl-2-Oxazolines to Aryl Carboxylic Acids

Abstract A method of hydrolyzing 2-aryl-4,4-dimethyl-2-oxazolines with trifluoromethanesulfonic anhydride is described which works well even for highly hindered systems where alternate methods fail.

A new method for preparing aqueous solutions of trialkylsulfonium and trialkylsulfoxonium hydroxides

Abstract Aqueous solutions of low molecular weight trialkylsulfonium and trialkylsulfoxonium hydroxides are prepared in quantiative yields from tetrabutylammonium hydroxide and trialkylsulf(ox)onium iodides using an extractive procedure.