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Featured researches published by Denny Castro.


International Journal of Infectious Diseases | 2012

High frequency of Helicobacter pylori in the esophageal mucosa of dyspeptic patients and its possible association with histopathological alterations

Monica Contreras; Víctor Salazar; María Alexandra García-Amado; Nelson Reyes; Miguel Aparcero; Olga Silva; Denny Castro; Roberto Romero; Pulchérie Gueneau; Fabián A. Michelangeli

BACKGROUND Helicobacter pylori gastric colonization is known to be high in symptomatic subjects. However, only a few reports on the presence of H. pylori in the esophageal mucosa have been published. The aim of this study was to assess the frequency of H. pylori in the esophagus of dyspeptic patients and its association with histopathology. METHODS The presence of H. pylori in the gastroesophageal mucosa was detected by fluorescence in situ hybridization (FISH) and PCR analysis of DNA extracted from gastric and esophageal biopsies of 82 symptomatic patients, using genus- and species-specific PCR primers. Alterations in the gastroesophageal mucosa were assessed by conventional histological techniques. RESULTS H. pylori in the stomach was detected by PCR and FISH, respectively, in 61% (n=43) and 90% (n=63) of dyspeptic patients, and in the esophagus in 70% (n=44) and 73% (n=46). The prevalence of cagA-positive strains by PCR varied from 50% (n=35) in the gastric mucosa to 65% (n=41) in the esophageal mucosa. By combining the results of both methods, H. pylori was present in the gastroesophageal mucosa in 86% (n=68) of patients. The association of the presence of bacteria, including H. pylori, in the esophageal mucosa with histopathological alterations was statistically significant between microabscesses and bacteria (r=0.656, p<0.0001) and PCR detection and pseudogoblet cells (r=0.25, p<0.047). CONCLUSIONS This is the first report of the occurrence of H. pylori in the esophageal mucosa from dyspeptic Venezuelan patients. These results demonstrate the high prevalence of H. pylori in the esophagus, and its presence was correlated with signs of inflammation.


Revista Venezolana de Oncología | 2007

Cáncer gástrico. Primera reunión de consenso. Agosto 2006

Jesús Felipe Parra; Rubén Hernández; Armando Gil A; Nery Uzcátegui; Augusta Honorato; Rafael Barrios Armas; Aron Krygier; Ángel Pérez; Yihad Kalek; Hugo Gori; Miguel Aparcero; Dervis Bandres; Manuel Bronstein; Ramón Poleo; Denny Castro; Johanel Wanderlinder; Ángela Ruiz; Simón Peraza; Aldo Reigosa; Ingrid Nass; Thais Rebolledo; María Aguilera; Ana Arcia; Núñez Patricia; Patricia Arbeloa; María Belén Fuentes; Eduardo Undreiner; Raúl Vera Gimón; Juan José Rodríguez; Santiago Gajzenberg


Revista Colombiana de Gastroenterologia | 2013

Case study of a sphincterotomy to remove stones from the common bile duct cholelithiasis biliary in a patient with total situs inversus

Denny Castro; Alejandro De Faria; Lisbeth Fuenmayor


GEN | 2005

Evolución a largo plazo de la metaplasia intestinal tipo III y la displasia gástrica en una zona de alto riesgo para cáncer gástrico

Olga Silva; Rita Márquez; Denny Castro; Jorge Vivas; Mayela Miranda; Simón Peraza; Gladys Lopez; Patricia Martín


GEN | 1996

Cáncer avanzado que simula cáncer gástrico precoz: presentación de tres casos

Gladys Lopez; Simón Peraza; Denny Castro; F Romero Ferrero; J Contreras Penuela


GEN | 1993

Aspecto macroscópico y microscópico en cáncer gástrico precoz

Denny Castro; Simón Peraza; Elsa Caro; Víctor Sánchez; Olga Andrade; Walter Oliver; Jorge Vivas; Gladis López


Revista GEN | 2017

CASO CLINICO: CARCINOMA GASTRICO CON RASGOS SARCOMATOIDES

Denny Castro; Nereida Lisbeth Duarte Ropero; Rosana Ramirez; Olga Silva


Revista GEN | 2017

ANGIOLIPOFIBROMA DE CIEGO. A PROPÓSITO DE UN CASO

Denny Castro; Luis A Ramírez; Carolina Arias; Olga Silva; Johana Marcano; Simón Peraza


Gen | 2017

Extraction Endoscopic of Body Strange of the Tract Digestive Superior Using Overtube of Local Design

Denny Castro; Hugo Castillo; Olga Silva; Johanna Marcano


Revista GEN | 2016

Resección mucosal endoscópica de hiperplasia linfoide reactiva de colon. Presentación de un caso

Denny Castro; Liliana Uzcátegui; Olga Silva; Simón Peraza

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