Denny Castro
Grupo México
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Publication
Featured researches published by Denny Castro.
International Journal of Infectious Diseases | 2012
Monica Contreras; Víctor Salazar; María Alexandra García-Amado; Nelson Reyes; Miguel Aparcero; Olga Silva; Denny Castro; Roberto Romero; Pulchérie Gueneau; Fabián A. Michelangeli
BACKGROUND Helicobacter pylori gastric colonization is known to be high in symptomatic subjects. However, only a few reports on the presence of H. pylori in the esophageal mucosa have been published. The aim of this study was to assess the frequency of H. pylori in the esophagus of dyspeptic patients and its association with histopathology. METHODS The presence of H. pylori in the gastroesophageal mucosa was detected by fluorescence in situ hybridization (FISH) and PCR analysis of DNA extracted from gastric and esophageal biopsies of 82 symptomatic patients, using genus- and species-specific PCR primers. Alterations in the gastroesophageal mucosa were assessed by conventional histological techniques. RESULTS H. pylori in the stomach was detected by PCR and FISH, respectively, in 61% (n=43) and 90% (n=63) of dyspeptic patients, and in the esophagus in 70% (n=44) and 73% (n=46). The prevalence of cagA-positive strains by PCR varied from 50% (n=35) in the gastric mucosa to 65% (n=41) in the esophageal mucosa. By combining the results of both methods, H. pylori was present in the gastroesophageal mucosa in 86% (n=68) of patients. The association of the presence of bacteria, including H. pylori, in the esophageal mucosa with histopathological alterations was statistically significant between microabscesses and bacteria (r=0.656, p<0.0001) and PCR detection and pseudogoblet cells (r=0.25, p<0.047). CONCLUSIONS This is the first report of the occurrence of H. pylori in the esophageal mucosa from dyspeptic Venezuelan patients. These results demonstrate the high prevalence of H. pylori in the esophagus, and its presence was correlated with signs of inflammation.
Revista Venezolana de Oncología | 2007
Jesús Felipe Parra; Rubén Hernández; Armando Gil A; Nery Uzcátegui; Augusta Honorato; Rafael Barrios Armas; Aron Krygier; Ángel Pérez; Yihad Kalek; Hugo Gori; Miguel Aparcero; Dervis Bandres; Manuel Bronstein; Ramón Poleo; Denny Castro; Johanel Wanderlinder; Ángela Ruiz; Simón Peraza; Aldo Reigosa; Ingrid Nass; Thais Rebolledo; María Aguilera; Ana Arcia; Núñez Patricia; Patricia Arbeloa; María Belén Fuentes; Eduardo Undreiner; Raúl Vera Gimón; Juan José Rodríguez; Santiago Gajzenberg
Revista Colombiana de Gastroenterologia | 2013
Denny Castro; Alejandro De Faria; Lisbeth Fuenmayor
GEN | 2005
Olga Silva; Rita Márquez; Denny Castro; Jorge Vivas; Mayela Miranda; Simón Peraza; Gladys Lopez; Patricia Martín
GEN | 1996
Gladys Lopez; Simón Peraza; Denny Castro; F Romero Ferrero; J Contreras Penuela
GEN | 1993
Denny Castro; Simón Peraza; Elsa Caro; Víctor Sánchez; Olga Andrade; Walter Oliver; Jorge Vivas; Gladis López
Revista GEN | 2017
Denny Castro; Nereida Lisbeth Duarte Ropero; Rosana Ramirez; Olga Silva
Revista GEN | 2017
Denny Castro; Luis A Ramírez; Carolina Arias; Olga Silva; Johana Marcano; Simón Peraza
Gen | 2017
Denny Castro; Hugo Castillo; Olga Silva; Johanna Marcano
Revista GEN | 2016
Denny Castro; Liliana Uzcátegui; Olga Silva; Simón Peraza