Derek B. Frewin
Royal Adelaide Hospital
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Publication
Featured researches published by Derek B. Frewin.
Neurology | 1974
Karen Elliott; Lucien J. Côcté; Derek B. Frewin; John A. Downey
The response of oral temperature and hand heat elimination to the placement of one arm in a water bath at 44°C was studied in normal women of different ages and in parkinsonian patients with or without levodopa therapy. The patients, whether or not receiving medication, had very low heat eliminations compared with the controls. In two patients with unilateral disease, the vascular responses in the affected hand were reduced in comparison with those in the unaffected side. These findings suggest that there is an abnormality of vascular control in Parkinsons disease caused by autonomic dysfunction, either in the central nervous system or efferent sympathetic pathways.
Life Sciences | 1974
Charles Steiner; L.B. Geffen; Morton Levitt; Derek B. Frewin; Robert J. Craig; Dean Hewish; John A. Downey; Wallace K. Luke
Abstract Dopamine-β-hydroxylase activity (DBH) has been measured in plasma obtained simultaneously from the pulmonary artery and left ventricle of fourteen patients who underwent diagnostic cardiac catheterisation. In the majority of these subjects the levels of enzyme activity in the arterial and venous blood were similar, indicating that inactivation of DBH had not occurred in its passage through the pulmonary circulation. One patient with pulmonary hypertension had a large a-v difference in enzyme activity that may have been caused by altered pulmonary haemodynamics. Three of the five subjects that undertook a standardised exercise test on a bicycle ergometer showed a significant increase in plasma DBH activity. There was no correlation between the increases in DBH activity and in cardiac index and heart rate.
The Journal of Clinical Pharmacology | 1991
Derek B. Frewin; Gregory J. Ryan; George C. Rennie
Sixteen patients who had essential hypertension were stabilized on either captopril or enalapril monotherapy and had 24‐hour blood pressure profiles monitored by using one of two automatic, non‐invasive ambulatory systems: Spacelabs 5300 (Squibb, Princeton, NJ) or PAR Physioport II (Kardiotec, Mannheim). In four subjects (group 1), ambulatory pressures were repeated 4 to 6 weeks later using the same equipment and the same drug. In four subjects (group 2), the drug was changed (dose ratio: captopril:enalapril, 5:1) after the first measurement, but the monitoring equipment was not changed. In four subjects (group 3), the drug was constant, but the equipment was changed for the second measurement of ambulatory pressure. In four subjects (group 4), both drug and equipment were reversed after the first measurement. The results showed that both drugs (given once daily) controlled blood pressure during the 24‐hour period, with no clinically significant difference between them.
Journal of Neurosurgery | 1983
J. Brian North; Robert Penhall; Ahmad Hanieh; Derek B. Frewin; William B. Taylor
Cardiovascular Research | 1983
Mary F Cummings; P. Steele; Leo Mahar; Derek B. Frewin; W. John Russell
Australian and New Zealand Journal of Medicine | 1972
Helena J. Frank; Derek B. Frewin; S. M. Robinson; P. H. Wise
Australian and New Zealand Journal of Medicine | 1971
Richard J. Burns; John A. Downey; Derek B. Frewin; Robert F. Whelan
Australian and New Zealand Journal of Ophthalmology | 1982
Derek B. Frewin; Elizabeth Chryssidis; Annette F. Howard
Australian and New Zealand Journal of Medicine | 1977
A. W. Harman; R. K. Penhall; B. G. Priestly; Derek B. Frewin; P. J. Phillips; A. R. Clarkson
Australian and New Zealand Journal of Medicine | 1977
Kerry A. McMahon; Derek B. Frewin; E. Gail Easterbrook; Elizabeth A. Hender; T. I. Lee; R. K. Penhalll