Derek H. Wells
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Featured researches published by Derek H. Wells.
Applied and Environmental Microbiology | 2011
Yuliya A. Primak; Mai Du; Michael C. Miller; Derek H. Wells; Alex Toftgaard Nielsen; Walter Weyler; Zachary Q. Beck
ABSTRACT The mevalonate pathway is utilized for the biosynthesis of isoprenoids in many bacterial, eukaryotic, and archaeal organisms. Based on previous reports of its feedback inhibition, mevalonate kinase (MVK) may play an important regulatory role in the biosynthesis of mevalonate pathway-derived compounds. Here we report the purification, kinetic characterization, and inhibition analysis of the MVK from the archaeon Methanosarcina mazei. The inhibition of the M. mazei MVK by the following metabolites derived from the mevalonate pathway was explored: dimethylallyl diphosphate (DMAPP), geranyl pyrophosphate (GPP), farnesyl pyrophosphate (FPP), isopentenyl monophosphate (IP), and diphosphomevalonate. M. mazei MVK was not inhibited by DMAPP, GPP, FPP, diphosphomevalonate, or IP, a proposed intermediate in an alternative isoprenoid pathway present in archaea. Our findings suggest that the M. mazei MVK represents a distinct class of mevalonate kinases that can be differentiated from previously characterized MVKs based on its inhibition profile.
Archive | 2010
Zachary Q. Beck; Richard R. Bott; Christopher L. Rife; Derek H. Wells; Jeffrey V. Miller
Archive | 2010
Zachary Q. Beck; Joseph C. Mcauliffe; Michael C. Miller; Rachel E. Muir; Alex T. Nielsen; Caroline M. Peres; Derek H. Wells; Walter Weyler
Archive | 2011
Zachary Q. Beck; David A. Estell; Jeffrey V. Miller; Christopher L. Rife; Derek H. Wells
Archive | 2013
Zachary Q. Beck; Marguerite A. Cervin; Gopal K. Chotani; Caroline M. Peres; Karl Sanford; Miles C. Scotcher; Derek H. Wells; Gregory M. Whited
Archive | 2014
Miles C. Scotcher; Derek H. Wells
Archive | 2017
Alex T. Nielsen; Caroline M. Peres; Derek H. Wells; Dmitrii V. Vaviline; Joseph C. Mcauliffe; Rachel E. Muir
Archive | 2017
Christopher L. Rife; Derek H. Wells
Archive | 2014
Zachary Q. Beck; Jeffrey W. Munos; Derek H. Wells; Jian Yao
Archive | 2013
Zachary Q. Beck; David A. Estell; Jeffrey V. Miller; James Ngai; Christopher L. Rife; Derek H. Wells