Derek Lowe | Researchain

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Featured researches published by Derek Lowe.

Archive | 2004

Preparation and use of aryl alkyl acid derivatives for the treatment of obesity

Roger A. Smith; Ann-Marie Campbell; Philip Coish; Miao Dai; Susan Jenkins; Derek Lowe; Stephen J. O'connor; Ning Su; Gan Wang; Mingbao Zhang; Lei Zhu

Journal of Pharmacology and Experimental Therapeutics | 2005

Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose

Thomas Claus; Derek Lowe; Yin Liang; Arthur I. Salhanick; Christine Keiper Lubeski; Ling Yang; Lynn Lemoine; Jian Zhu; Kevin B. Clairmont

Bioorganic & Medicinal Chemistry Letters | 2004

In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.

Derek Lowe; Steven Magnuson; Ning Qi; Ann-Marie Campbell; James H. Cook; Zhenqiu Hong; Ming Wang; Furahi Achebe; Harold Kluender; Wai C. Wong; William Bullock; Arthur I. Salhanick; Terri Witman-Jones; Mary E. Bowling; Christine Keiper; Kevin B. Clairmont

Archive | 2005

Preparation and Use of Biphenyl-4-Yl-Carbonylamino Acid Derivatives for the Treatment of Obesity

Roger A. Smith; Stephen J. O'connor; Philip Coish; Derek Lowe; Roger Clark; Jeffrey Stebbins; Ann-Marie Campbell; Christiana Akuche; Tatiana Shelekhin

Archive | 2002

Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation

Derek Lowe; Philip Wickens; Xin Ma; Mingbao Zhang; William Bullock; Philip Coish; Ingo A. Mugge; Andreas Stolle; Ming Wang; Yamin Wang; Chengzhi Zhang; Hai-Jun Zhang; Lei Zhu; Manami Tsutsumi; James N. Livingston

Archive | 2006

Preparation and use of biphenyl amino acid derivatives for the treatment of obesity

Roger A. Smith; Derek Lowe; Tatiana Shelekhin; Georgiy Bondar; Philip Coish; Stephen J. O'connor

Tetrahedron Letters | 2005

4,5-disubstituted cis-pyrrolidinones as inhibitors of 17β-hydroxysteroid dehydrogenase II. Part 1: Synthetic approach

James H. Cook; Jeremy Barzya; Catherine Brennan; Derek Lowe; Yamin Wang; Aniko Redman; William J. Scott; Jill E. Wood

Bioorganic & Medicinal Chemistry Letters | 2006

Substituted indanylacetic acids as PPAR-α–γ activators

Derek Lowe; Neil Bifulco; William Bullock; Thomas Claus; Philip Coish; Miao Dai; Fernando E. Dela Cruz; David Dickson; Dongping Fan; Helana Hoover-Litty; Tindy Li; Xin Ma; Gretchen Mannelly; Mary-Katherine Monahan; Ingo Muegge; Stephen J. O’Connor; Tatiana Shelekhin; Andreas Stolle; Laurel Sweet; Ming Wang; Yamin Wang; Chengzhi Zhang; Hai-Jun Zhang; Mingbao Zhang; Kake Zhao; Qian Zhao; Jian Zhu; Lei Zhu; Manami Tsutsumi

Organic Letters | 2003

Carboxylate-directed highly stereoselective homogeneous hydrogenation of cyclic olefins with Wilkinson's catalyst.

Mingbao Zhang; Lei Zhu; Xin Ma; Miao Dai; Derek Lowe

Bioorganic & Medicinal Chemistry Letters | 2007

Indanylacetic acids as PPAR-δ activator insulin sensitizers

Philip Wickens; Chengzhi Zhang; Xin Ma; Qian Zhao; John Amatruda; William Bullock; Michael Burns; Louis-David Cantin; Chih-Yuan Chuang; Thomas Claus; Miao Dai; Fernando E. Dela Cruz; David Dickson; Frederick J. Ehrgott; Dongping Fan; Sarah Heald; Martin F. Hentemann; Christiana Iwuagwu; Jeffrey S Johnson; Ellalahewage Kumarasinghe; David Ladner; Rico C. Lavoie; Sidney X. Liang; James N. Livingston; Derek Lowe; Steve Magnuson; Gretchen Mannelly; Ingo A. Mugge; Herbert Ogutu; ‡ Susan Pleasic-Williams

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