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Dive into the research topics where Derya Uçmak is active.

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Featured researches published by Derya Uçmak.


Journal of The European Academy of Dermatology and Venereology | 2013

Oxidative stress index may play a key role in patients with pemphigus vulgaris.

Yavuz Yesilova; Derya Uçmak; Sahabettin Selek; S.B. Dertlioğlu; B. Sula; F. Bozkus; Enver Turan

Background  Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, including atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus and alopecia areata. In PV, the increased production of ROS from activated neutrophils reduces the concentrations of antioxidant vitamins and enzymes.


International Journal of Rheumatic Diseases | 2017

Sleep quality in patients with psoriatic arthritis

Orhan Gezer; İbrahim Batmaz; Mustafa Akif Sariyildiz; Bilal Sula; Derya Uçmak; Mehtap Bozkurt; Kemal Nas

The purpose of this study was to determine the effects of psoriatic arthritis (PsA) on sleep quality and investigate the association between sleep quality and clinical parameters of PsA, quality of life and psychological state in patients with PsA.


Journal of Clinical Laboratory Analysis | 2015

Serum Cytokine Levels in Behçet's Disease

Zeynep Meltem Akkurt; Mehtap Bozkurt; Derya Uçmak; Hatice Yüksel; Haydar Uçak; Bilal Sula; Zeynep Özkurt; Mehmet Yıldız; Dicle Akdeniz; Mustafa Arica

The aim of this study is to investigate and compare the serum levels of various cytokines in patients with Behçets Disease and healthy controls.


Postepy Dermatologii I Alergologii | 2013

Determination of dermatology life quality index, and serum C-reactive protein and plasma interleukin-6 levels in patients with chronic urticaria.

Derya Uçmak; Meltem Akkurt; Gülten Toprak; Yavuz Yesilova; Enver Turan; Ismail Yıldız

Introduction C-reactive protein (CRP) and interleukin-6 (IL-6), which is one of its most important simulators, were determined in great amounts in the sera of patients with chronic urticaria (CU). Aim To determine the levels of IL-6 in patients with urticaria, and evaluate its relationship with urticaria activity scores and Dermatology Life Quality Index (DLQI). Material and methods Fifty-three patients with CU were included in the study successively by determining their urticaria activity scores (0-3) and DLQI (0-5). The CRP and IL-6 were measured by immune assay methods. Thirty-two healthy subjects were included as a control group. Results Serum levels of IL-6 and CRP were significantly higher in patients with CU compared to healthy controls (p < 0.001, p = 0.026 respectively). There was a statistically significant correlation among urticaria activity scores and IL-6 and CRP concentration (p = 0.004, p = 0.042). This correlation was more significant in patients who had moderate and severe disease activity scores than in those who had mild disease activity score (p < 0.001, p < 0.001, respectively). There was a statistically significant association between DLQI and IL-6 (p = 0.025). This correlation was very significant in patients who had severe and very severe disease activity scores (p < 0.001, p < 0.001, respectively). DLQI scores and serum levels of IL-6 were significantly different in the very severe group compared to healthy controls (p = 0.024). Conclusions The levels of CRP and IL-6 are increased in patients with CU. A relationship of DLQI and urticaria activity scores with CRP and IL-6 was found. These findings support the relationship between the inflammatory process in CU and the clinical findings.


Journal of Dermatological Treatment | 2013

Efficacy of topical tacrolimus for the treatment of persistent pruritus ani in patients with atopic dermatitis

Haydar Uçak; Betül Demir; Demet Cicek; Selma Bakar Dertlioglu; Zeynep Meltem Akkurt; Derya Uçmak; Nurhan Halisdemir

Background: Pruritus ani (PA) is defined as intense chronic itching affecting perianal skin. Objective: We aimed to determine the efficacy of topical tacrolimus treatment in atopic dermatitis (AD) patients who have PA. Methods: The study included 32 patients with AD who were suffering PA. Patients were randomized into two groups. In total, 16 patients used 0.03% tacrolimus ointment and 16 patients used vaseline as placebo. All groups applied topical treatments to their perianal area twice daily for 4 weeks. The treatments were then reversed for 4 weeks after a 2 weeks wash out period. Results: In total, 32 patients with AD who had refractory anal itching were enrolled in this study. None of the patients had obtained successful results with previous treatments. There was a statistically significant decrease in the recorded EASI, DLQI and itching scores for the tacrolimus group compared to the placebo group at weeks 4 and 6 of treatment (p < 0.05). Conclusion: Topical tacrolimus treatment was well tolerated and effective in controlling persistent PA in AD patients.


International Journal of Dermatology | 2015

Clinical and dermoscopic evaluation of cutaneous leishmaniasis

Erhan Ayhan; Derya Uçmak; Sule Nergiz Baykara; Zeynep Meltem Akkurt; Mustafa Arica

Dermoscopy is a method to aid in the visualization of the epidermis and dermis. In recent years, the use of dermoscopy in the diagnosis of non‐melanocytic lesions such as those of leishmania cutis has increased.


Redox Report | 2012

Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress

Yavuz Yesilova; Enver Turan; Derya Uçmak; Sahabettin Selek; I˙brahim Halil Yavuz; Osman Tanrıkulu

Abstract Vitiligo is a common disorder that results in depigmented areas of the skin. The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. Paraoxonase 1 can be used as an indicator in determining oxidative stress existent in the pathogenesis of vitiligo diseases.


Cutaneous and Ocular Toxicology | 2014

Comparative study of 5% and 2.5% potassium hydroxide solution for molluscum contagiosum in children

Derya Uçmak; Meltem Akkurt; Seval Dogruk Kacar; Bilal Sula; Mustafa Arica

Abstract Background: Molluscum contagiosum (MC) is a pediatric viral infection that is fairly contagious. Although various treatment methods are available, the presence of facial lesions limits options of therapy. Aim: We aimed to test an alternative treatment consisting of application of two different concentrations of potassium hydroxide (of KOH 5% solution and of KOH 2.5% solution) aqueous solution. Methods: In this study we evaluated the effectiveness and side-effects of daily applications of potassium hydroxide (KOH) aqueous solution at 2.5% and 5% concentrations, twice daily in 29 children with MC. Out of a total of 29 patients with molluscum contagiosum included in the study, 13 patients in the 2.5% KOH group and 12 patients in the KOH 5% group completed the study. Families were instructed to apply potassium hydroxide twice a day. The assessment of response and side-effects were performed on days 0, 15, 30, 45 and 60 (visits were numbered 1, 2, 3, 4 and 5, respectively) and one month after. Results: We had a total of 11 (44%) patients who completely recovered after the fifth visit. While eight (66.7%) of these 11 patients were in the 5% treatment group, three (23.1%) patients were in the 2.5% treatment group, and there was a statistically meaningful difference (p < 0.047). Patients with fewer lesions remitted better (p < 0.05). When number of lesions were taken into consideration, difference between the two treatment groups appeared after the fourth visit (p < 0.001). There were no statistical differences between the two groups with respect to side-effects (p = 0.682). Conclusions: Potassium hydroxide solution at a concentration of 5% was more effective than 2.5% in our patients. The treatment was well-tolerated on the face with the advantage of administration of lower concentrations. This study suggests potassium hydroxide may be a more preferable mode of treatment for molluscum contagiosum lesions on the face.


Clinical and Experimental Dermatology | 2015

Evaluation of orbital arteries with colour Doppler ultrasonography in patients with psoriasis

Zeynep Meltem Akkurt; Hatice Gümüş; A. Aktürk; Derya Uçmak; Fatih Mehmet Türkcü; Z. Gürsel Özkurt; M. S. Durmaz; Aslan Bilici

To evaluate the blood flow in arteries of the orbit in patients with psoriasis.


Indian Journal of Dermatology, Venereology and Leprology | 2013

The frequency of osteoporosis in patients with pemphigus vulgaris on treatment

Derya Uçmak; Mehmet Harman; Feyzullah Uçmak; Veysi Akpolat

BACKGROUND Pemphigus vulgaris was almost fatal before the advent of glucocorticoids. Unfortunately, the high doses and prolonged administration of glucocorticoids, which often needed to control the disease, result in numerous adverse effects many of which are serious. AIMS To evaluate the patients with pemphigus vulgaris on treatment in respect of osteoporosis and to compare the frequency of osteoporosis in these patients with the healthy ones. METHODS The study consisted of 40 patients with pemphigus vulgaris and 34 healthy controls. Bone mineral density measurements were obtained by dual- energy X-ray absorptiometry. Blood serum, bone parameters, and biochemical hormonal measurements were examined in both groups. RESULTS When the bone mineral density values of patients with pemphigus vulgaris were compared with those of the control group, there was no significant difference between hip bone mineral density values, while lumbar region T and Z scores were found significantly low in the patient group (p = 0.034 and p = 0.006, respectively). Osteoporosis, osteopenia, and normal dual-energy X-ray absorptiometry rates in the patient group were found to be 32.5%, 32.5%, and 35%, respectively. These rates were found to be 18%, 23%, and 59% in control group, respectively. There were more fractures in the patient group and the difference was statistically significant (p = 0.004). CONCLUSION An increase in osteoporosis frequency and secondary fracture to osteoporosis in the patients with pemphigus vulgaris was detected.

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