Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Desh Deepak is active.

Publication


Featured researches published by Desh Deepak.


Clinica Chimica Acta | 2010

CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD.

Arpana Vibhuti; Ehtesham Arif; Aastha Mishra; Desh Deepak; Bhawani Singh; Irfan Rahman; Ghulam Mohammad; M. A. Qadar Pasha

BACKGROUND The genetic susceptibility to chronic obstructive pulmonary disease (COPD) depends on detoxification and antioxidant enzymes, which detoxify cigarette smoke reactive components that, otherwise, generate oxidative stress. METHODS In a case-control study of 346 subjects with and without COPD, we examined the polymorphisms 462Ile/Val, 3801T/C of CYP1A1, -3860G/A of CYP1A2 and -930A/G, 242C/T of CYBA individually or in combination and their contribution to oxidative stress markers by measuring malondialdehyde (MDA), catalase (CAT), glutathione (GSH) and glutathione peroxidase (GPx). RESULTS COPD patients had significantly increased MDA concentration (p<0.001) and decreased CAT activity, GSH concentration, GPx activity (p< or =0.01). The patients were over-represented by the alleles 462Val, 3801C of CYP1A1 and -930G, 242C of CYBA (p<0.001, p=0.003, p=0.030 and p=0.031, respectively) and consequently the haplotypes of same alleles i.e. 462Val:3801C, 462Val:3801T and -930G:242C (p=0.048, p=0.016 and p=0.039, respectively). Similarly, CYP1A1 and CYP1A2 haplotypes, 462Val:3860G and 462Val:3801T:3860G were significantly over-represented (p=0.001 and p=0.003), respectively in patients. The same alleles-associated genotype-combinations between genes were more prevalent in patients. Of note, the genotypes, 462Ile/Val+Val/Val, 3801TC+CC of CYP1A1 and -930AG+GG of CYBA associated with increased MDA concentration (p=0.018, p=0.045 and p=0.017, respectively), decreased CAT activity (p<0.0001, p=0.080 and p<0.0001, respectively) and GSH concentration (p<0.0001, p=0.0002 and p=0.011, respectively) in patients. CONCLUSION The identified alleles, its haplotypes and the genotype-combination along with increased oxidative stress, signify the importance in susceptibility to COPD.


Clinica Chimica Acta | 2008

COX2 and p53 risk-alleles coexist in COPD.

Ehtesham Arif; Arpana Vibhuti; Desh Deepak; Bhawani Singh; Mohd. Saeed Siddiqui; M. A. Qadar Pasha

BACKGROUND Cigarette smoke stimulates airway epithelial cells to release pro-inflammatory cytokines which influence various inflammation-related genes, including COX2, whereas p53 expression is known to alter in such a condition. Since both the genes share several common physiological functions including inflammation and oxidative stress, we investigated within gene and gene-gene interactions towards susceptibility to the disease. METHOD In a prospective gene-association study we conducted PCR-RFLP for genotyping the COX2 -765G/C and 8473T/C and p53 72Pro/Arg polymorphisms in 229 COPD patients and 147 healthy controls. RESULTS The -765GC+CC genotypes of COX2 and Pro/Pro+Pro/Arg genotypes of p53 were prevalent in patients with significant odds ratio, 2.05 and 2.30, respectively (p=0.001; p=0.009, respectively), as a consequence, the -765C and 72Pro alleles were prevalent (p<or=0.001). Individually, the 8473T/C polymorphism did not associate with the disease (p=NS), however, it did in the haplotype -765C:8473C, which was significantly higher in patients (p<0.0001). Based on its prevalence, the three alleles were identified as risk-alleles in patients. The combinations of the genotypes containing 3, 4 and 5 risk alleles of the 3 polymorphisms were significantly over-represented in patients, whereas, the genotypes combinations containing 0, 1 and 2 risk alleles were significantly higher in controls (p=0.0004). The pairwise gene-gene interactions validated prevalence of risk-alleles associated pairing of genotypes such as the Pro/Pro+ Pro/Arg with -765GC+-765CC in patients (p=0.01). CONCLUSION The prevalence of COX2 and p53 risk-alleles contributes towards susceptibility to the disease.


Case reports in anesthesiology | 2011

Filgrastim as a rescue therapy for persistent neutropenia in a case of dengue hemorrhagic Fever with acute respiratory distress syndrome and myocarditis.

Desh Deepak; Rakesh Garg; Mridula Pawar; Neerja Banerjee; Rakesh Solanki; Indubala Maurya

Pathogenesis of dengue involves suppression of immune system leading to development of characteristic presentation of haematological picture of thrombocytopenia and leucopenia. Sometimes, this suppression in immune response is responsible for deterioration in clinical status of the patient in spite of all specific and supportive therapy. Certain drugs like steroids are used for rescue therapy in conditions like sepsis. We present a novel use of filgrastim as a rescue therapy in a patient with dengue hemorrhagic fever (DHF) with acute respiratory distress syndrome (ARDS), myocarditis, and febrile neutropenia and not responding to standard management.


Journal of Laboratory Physicians | 2018

Cytopathological examination of bronchoalveolar lavage fluid in diagnosis of pulmonary alveolar proteinosis

Manjari Kishore; Manju Kaushal; Desh Deepak; Manju Kumari

Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the deposition of extracellular lipoproteinaceous material within the air spaces. Although the diagnosis is mainly based on histopathological findings, sometimes, the diagnostic yield of transbronchial and even open lung biopsy can be unsatisfactory. The advantage with bronchoalveolar lavage (BAL) cytology is that apart from being safer for the patient, it can sample a much wider area and help in giving an early diagnosis and treatment to the patient. Herein, we present a case of PAP diagnosed on BAL fluid cytology in an elderly female.


Journal of clinical and diagnostic research : JCDR | 2016

Pulmonary Hamartoma Mimicking Malignancy: A Cytopathological Diagnosis

Manjari Kishore; Prajwala Gupta; Preeti; Desh Deepak

Pulmonary Hamartomas (PH) are benign tumour-like lesions of lung with an uncommon occurrence and pose a diagnostic challenge on chest radiograph. Fine Needle Aspiration Cytology (FNAC) can lead to a definitive diagnosis as well as distinguishes these from malignant lung mass. Most of the patients are asymptomatic and incidentally detected on routine chest radiographs. We report a case of pulmonary hamartoma where the patient was symptomatic and a possibility of malignant neoplasm was considered until the FNAC concluded the diagnosis.


Case Reports | 2014

Pregnancy presenting as hyperthyroidism with negative urine pregnancy test.

Rita Jindal; Desh Deepak; Gopal Chandra Ghosh; Mamta Gupta

A 22-year-old lactating mother presented with symptoms of uneasiness, palpitation, tachycardia and exophthalmos. She had an abdominal lump suggestive of 26 weeks uterine size but her urine pregnancy test was negative. Her thyroid profile was suggestive of hyperthyroidism. Gynaecological and ultrasonographic findings revealed a hydatidiform mole. She had a low β-human chorionic gonadotropin level that surprisingly increased after suction and evacuation. The paradoxical findings that appeared as erroneous laboratory results could be explained by the ‘high-dose hook effect’ after a review of literature. One week after the evacuation, the patients thyroid profile and symptoms resolved completely without any treatment for hyperthyroidism.


Indian Journal of Pharmacology | 2010

Flucytosine for treatment of Candida albicans in H1N1-positive patient.

Tanvir Samra; Amlendu Yadav; Neerja Banerjee; Mridula Pawar; Desh Deepak

A 17-year-old H1N1-positive patient was successfully extubated after 25 days of ventilatory support for treatment of viral pneumonia which was complicated by empyema thoracis due to Candida albicans. Hematogenous spread was suspected as simultaneous culture of ascitic fluid identified Candida species sensitive to flucytosine but resistant to amphotericin B and azole group of antifungals. Monotherapy with flucytosine led to clinical and radiological improvement.


Biochemical and Biophysical Research Communications | 2007

Genetic polymorphisms of GSTP1 and mEPHX correlate with oxidative stress markers and lung function in COPD.

Arpana Vibhuti; Ehtesham Arif; Desh Deepak; Bhawani Singh; M.A. Qadar Pasha


Clinical Biochemistry | 2007

Correlation of oxidative status with BMI and lung function in COPD

Arpana Vibhuti; Ehtesham Arif; Desh Deepak; Bhawani Singh; M.A. Qadar Pasha


Clinica Chimica Acta | 2007

Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease

Ehtesham Arif; Arpana Vibhuti; Pervez Alam; Desh Deepak; Bhawani Singh; Mohammad Athar; M. A. Qadar Pasha

Collaboration


Dive into the Desh Deepak's collaboration.

Top Co-Authors

Avatar

Bhawani Singh

Dr. Ram Manohar Lohia Hospital

View shared research outputs
Top Co-Authors

Avatar

Arpana Vibhuti

Savitribai Phule Pune University

View shared research outputs
Top Co-Authors

Avatar

M. A. Qadar Pasha

Institute of Genomics and Integrative Biology

View shared research outputs
Top Co-Authors

Avatar

Ehtesham Arif

University of Pennsylvania

View shared research outputs
Top Co-Authors

Avatar

Brijesh Sharma

Post Graduate Institute of Medical Education and Research

View shared research outputs
Top Co-Authors

Avatar

M.A. Qadar Pasha

Savitribai Phule Pune University

View shared research outputs
Top Co-Authors

Avatar

Manjari Kishore

Dr. Ram Manohar Lohia Hospital

View shared research outputs
Top Co-Authors

Avatar

Minakshi Bhardwaj

Dr. Ram Manohar Lohia Hospital

View shared research outputs
Top Co-Authors

Avatar

Mridula Pawar

Dr. Ram Manohar Lohia Hospital

View shared research outputs
Top Co-Authors

Avatar

Neerja Banerjee

Dr. Ram Manohar Lohia Hospital

View shared research outputs
Researchain Logo
Decentralizing Knowledge