Desmond T.B. Yeo

Local specific absorption rate in high-pass birdcage and transverse electromagnetic body coils for multiple human body models in clinical landmark positions at 3T

To use electromagnetic (EM) simulations to study the effects of body type, landmark position, and radiofrequency (RF) body coil type on peak local specific absorption rate (SAR) in 3T magnetic resonance imaging (MRI).

Fat‐referenced MR thermometry in the breast and prostate using IDEAL

To demonstrate a three‐echo fat‐referenced MR thermometry technique that estimates and corrects for time‐varying phase disturbances in heterogeneous tissues.

Exploration of MR-guided head and neck hyperthermia by phantom testing of a modified prototype applicator for use with proton resonance frequency shift thermometry

Abstract Magnetic resonance thermometry (MRT) offers non-invasive temperature imaging and can greatly contribute to the effectiveness of head and neck hyperthermia. We therefore wish to redesign the HYPERcollar head and neck hyperthermia applicator for simultaneous radio frequency (RF) heating and magnetic resonance thermometry. In this work we tested the feasibility of this goal through an exploratory experiment, in which we used a minimally modified applicator prototype to heat a neck model phantom and used an MR scanner to measure its temperature distribution. We identified several distorting factors of our current applicator design and experimental methods to be addressed during development of a fully MR compatible applicator. To allow MR imaging of the electromagnetically shielded inside of the applicator, only the lower half of the HYPERcollar prototype was used. Two of its antennas radiated a microwave signal (150 W, 434 MHz) for 11 min into the phantom, creating a high gradient temperature profile (ΔTmax = 5.35 °C). Thermal distributions were measured sequentially, using drift corrected proton resonance frequency shift-based MRT. Measurement accuracy was assessed using optical probe thermometry and found to be about 0.4 °C (0.1–0.7 °C). Thermal distribution size and shape were verified by thermal simulations and found to have a good correlation (r2 = 0.76).

MRI of thiel‐embalmed human cadavers

To explain the observed considerable loss of signal and contrast when Thiel‐embalmed human cadavers are imaged using clinical magnetic resonance imaging (MRI) sequences, especially those based on spin‐echo MRI.

Validation of MR thermometry: Method for temperature probe sensor registration accuracy in head and neck phantoms

Abstract Purpose: Magnetic resonance thermometry (MRT) is an attractive means to non-invasively monitor in vivo temperature during head and neck hyperthermia treatments because it can provide multi-dimensional temperature information with high spatial resolution over large regions of interest. However, validation of MRT measurements in a head and neck clinical set-up is crucial to ensure the temperature maps are accurate. Here we demonstrate a unique approach for temperature probe sensor localisation in head and neck hyperthermia test phantoms. Methods: We characterise the proton resonance frequency shift temperature coefficient and validate MRT measurements in an oil–gel phantom by applying a combination of MR imaging and 3D spline fitting for accurate probe localisation. We also investigate how uncertainties in both the probe localisation and the proton resonance frequency shift (PRFS) thermal coefficient affect the registration of fibre-optic reference temperature probe and MRT readings. Results: The method provides a two-fold advantage of sensor localisation and PRFS thermal coefficient calibration. We provide experimental data for two distinct head and neck phantoms showing the significance of this method as it mitigates temperature probe localisation errors and thereby increases accuracy of MRT validation results. Conclusions: The techniques presented here may be used to simplify calibration experiments that use an interstitial heating device, or any heating method that provides rapid and spatially localised heat distributions. Overall, the experimental verification of the data registration and PRFS thermal coefficient calibration technique provides a useful benchmarking method to maximise MRT accuracy in any similar context.

Rapid HIFU autofocusing using the entire MR-ARFI image

Phase aberrations and attenuations caused by bone can defocus HIFU in the brain and organs behind the ribcage. To refocus the beam, MR-ARFI can be used to measure tissue displacements created by each element in the transducer, and optimize driving signal delays and amplitudes. We introduce a new MR-ARFI-based autofocusing method that requires many fewer image acquisitions than current methods. The method is validated in simulations of bone and brain HIFU transducers, and compared to a conventional method.

Referenced MR thermometry using three-echo phase-based fat water separation method

A three-point image reconstruction method for internally referenced MR thermometry was developed. The technique exploits the fact that temperature-induced changes in the water resonance frequency are small relative to the chemical shift difference between water and fat signals. This property enabled the use of small angle approximations to derive an analytic phase-based fat-water separation method for MR thermometry. Ethylene glycol and cream cool-down experiments were performed to validate measurement technique. Over a cool-down temperature range of 20 °C, maximum deviation between probe and MR measurement (averaged over 1.3 cm3 region surrounding probe) was 0.6 °C and 1.1 °C for ethylene glycol and cream samples, respectively.