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Dive into the research topics where Dhevy Watana is active.

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Featured researches published by Dhevy Watana.


American Journal of Kidney Diseases | 1999

Tubular function and tubulointerstitial disease

Prasit Futrakul; Saowani Yenrudi; Narisa Futrakul; Rajanee Sensirivatana; Pornchai Kingwatanakul; Jakchai Jungthirapanich; Thumronkprawat Cherdkiadtikul; Aimon Laohapaibul; Dhevy Watana; Vararat Singkhwa; Sithivudh Futrakul; Pongsak Pongsin

Tubular transport determined by the fractional excretion (FE) of filtered solutes was studied in 129 nephrotic patients; 72 patients with mesangial proliferation (MesP-NS) and intact tubulointerstitium (group 1), 13 patients with MesP-NS and superimposed tubulointerstitial fibrosis (TIF; group 2), 27 patients with mild focal segmental glomerulosclerosis (FSGS; group 3), and 17 patients with severe FSGS (group 4). In the 72 nephrotic patients with MesP-NS and normal tubulointerstitium (no TIF), tubular transport was intact (FE of sodium [FENa], 0.5 +/- 0.5; FE of calcium [FECa], 0.3 +/- 0.3; FE of phosphate [FEPO4], 14 +/- 13; FE of uric acid [FEUA], 9.8 +/- 5; FE of magnesium [FEMg], 1.3 +/- 0.5). In the 13 nephrotic patients with MesP-NS and superimposed TIF (4.9% +/- 2%), there was no difference in FE solutes from those in group 1 except for FEMg (3.3 +/- 0.9; P < 0.001). In the 27 nephrotic patients with mild FSGS (TIF, 28% +/- 9%), four of five variables of FE solutes (FENa, 1.2 +/- 0.7; P < 0.001; FECa, 0.9 +/- 0.8; P < 0.001; FEPO4, 17 +/- 12; P, not significant; FEUA, 16.5 +/- 8; P < 0.001; FEMg, 4. 1 +/-1; P < 0.001) were significantly different from those of patients with MesP-NS without TIF, and two of five variables (FECa, FEMg) were statistically different from those of patients with MesP-NS with TIF. In the severe category of FSGS (TIF, 69% +/-19%), all FE solutes were statistically different from the other groups (FENa, 4.8 +/- 3; FECa, 2 +/- 1; FEPO4, 47 +/- 24; FEUA, 37 +/- 18; FEMg, 12 +/- 6). Thus, the results imply that (1) normal tubular transport reflects an underlying intact tubulointerstitial structure, whereas tubular dysfunction indicates an underlying tubulointerstitial disease, and (2) FEMg is the most sensitive index to detect an early abnormality of tubular structure and function.


Renal Failure | 2000

PERITUBULAR CAPILLARY FLOW DETERMINES TUBULOINTERSTITIAL DISEASE IN IDIOPATHIC NEPHROTIC SYNDROME

Narisa Futrakul; Saowanee Yenrudi; Rajanee Sensirivatana; Dhevy Watana; Aimon Laohapaibul; Krisda Watanapenphaibul; Pornchai Kingwatanakul; Prasit Futrakul; Sithivudh Futrakul

The spatial relationship between renal perfusion and nephronal structure was determined in 51 nephrotic patients consisting of 11 patients with steroid sensitive, minimal change (MC) nephrosis, 12 patients with steroid resistant, mesangial proliferative (MesP) nephrosis and without tubulointerstitial fibrosis (TIF), 11 patients with steroid resistant, MesP nephrosis and with low grade TIF and 17 patients with focal segmental glomerulosclerosis (FSGS). The intrarenal hemodynamic study revealed a unique correlation between renal perfusion and nephronal structure. A normal or slight reduction in peritubular capillary flow observed in MC or mild MesP nephrosis correlates with an intact tubulointerstitial structure. A moderate reduction in peritubular capillary flow observed in steroid resistant, MesP nephrosis induces a low incidence of TIF. A severe reduction in peritubular capillary flow denotes a higher incidence of TIF as that observed in nephrosis with FSGS. Thus, it is of notion that the reduction in renal perfusion precedes the development of tubulointerstitial fibrosis and thereby supports the concept of renal perfusion as a crucial determinant of nephronal structure.


American Journal of Nephrology | 1997

Glomerular Endothelial Dysfunction Determines Disease Progression: A Hypothesis

Prasit Futrakul; Visith Sitprija; Saowanee Yenrudi; Makumkrong Poshyachinda; Rajanee Sensirivatana; Dhevy Watana; Vararat Singklwa; Jaakchai Jungthirapanich; Narisa Futrakul

A glomerular endothelial function with its hemodynamic impact is proposed to determine disease progression. In the clinical settings associated with an intact endothelial function, such as minimal-change steroid-sensitive nephrosis, the early phase of diabetes mellitus and the early stage of an experimental model of renal ablation in animals, it was observed that adequate renal perfusion correlates with the intact structure and function of the nephron with no evidence of disease progression. In contrast, the clinical settings associated with endothelial dysfunction, such as chronic glomerulonephropathy, the late stage of diabetes mellitus and a renal ablation model in animals, are usually associated with a reduction in renal perfusion. The magnitude of renal hypoperfusion observed in all forms of chronic glomerulonephropathies is proportional to the degree of clinical severity. A progressive pattern of renal hypoperfusion is uniquely observed when disease severity progresses. In this context, a new therapeutic maneuver aiming to improve renal perfusion is proposed for treating glomerulonephropathy with disease progression and preventing it from developing to end-stage renal disease.


Nephron | 1991

Renal Tubular Defect in Nephrotic Syndrome Associated with Focal Segmental Glomerulosclerosis

Prasit Futrakul; Makumkrong Poshyachinda; Chawalit Preeyasombati; Rajanee Sensirivatana; Dhevy Watana

Prasit Futrakul, Chulalongkorn Medical School Hospital, Rama IV Road, Bangkok 10330 (Thailand) Dear Sir, Table 1. Renal function studies Tubular insult with various degrees of histopathologic expression has consistently been encountered in nephrotic syndrome associated with focal segmental glomerulosclerosis. However, relating evidence supporting tubular functional abnormality was sporadically documented of which its significance is generally underestimated by the clinician [1–3]. In this respect, we have, therefore, observed tubular functional defect attested during 10–12 h fasting in 18 children with clinically steroid-resistant nephrosis and histopathologically proven FSGS. As depicted in table 1, there was a trend of increased urinary excretions of all the solutes above those of the normal control values during active proteinuria. Nevertheless, the differences were statistically significant only in the fractional excretion of phosphate and uric acid. In addition, simultaneous assessments of effective renal plasma flow using 131I-labeled para-aminohippurate and glomerular filtration rate using 99mTc-labeled DTPA during active proteinuria revealed a preponderantly low effective renal plasma flow compared to glomerular filtration rate yielding a high filtration fraction. Therapeutic combination of prednisolone (1–2 mg/ kg/day), dipyridamole (10–15 mg/kg/day), calcium channel blocker (Nifedipine, 1–3 mg/kg/day) and ACE inhibitor (0.5–2 mg/kg/day) had been medicated to all 18 nephrotics with the duration of treatment varying from 6 to 24 months. Interestingly, reassessments of renal functions following the therapeutic trial revealed a regression of enhanced tubular excretion of solute in conjunction with the improvement of renal hemodynamics. Normal FSGS Remission active


American Journal of Nephrology | 1997

Consultants for the American Journal of Nephrology 1997

Lionel Rostaing; Olivier Martinet; Jean-Marc Cisterne; Josette Icart; Marie-Hélène Chabannier; Dominique Durand; Ghulam Hassan Malik; Jamal Al-Wakeel; Suleiman Al-Mohaya; Ahmad Hassan Mitwalli; Riad A. Sulimani; Mohammad Shihabudin Kechrid; Hazem El Gamal; Satoru Suzuki; Hoyu Takahashi; Hirokazu Sato; Ahmed Shafik; Ghazali A. Khan; Frances I. Lewis; Manash Dasgupta; Jolanta Karpinski; Serge Jothy; Victor Radoux; Mortimer Levy; Dana Baran; Prasit Futrakul; Visith Sitprija; Saowanee Yenrudi; Makumkrong Poshyachinda; Rajanee Sensirivatana

Consultants for the American Journal of Nephrology 1997 Abrass, Christine Adler, Sharon Agodoa, Lawrence Akmal, Mohammad Anderson, Sharon Andreucci, Vittorio Avram, Morel Bakris, George Balow, James Bennette, William Boswell, William Breyer, Julia Langman, Craig Levin, Nathan Limb, Victoria Maroni, Bradley Martinez-Maldonado, Manuel Matthew, Weir R. Mitch, William Mushnick, Robert Nissenson, Allan Nolph, Karl Nosrati, Saeid


Journal of the Medical Association of Thailand Chotmaihet thangphaet | 1992

Intrarenal hemodynamic abnormality in severe form of glomerulonephritis: therapeutic benefit with vasodilators.

Prasit Futrakul; Pochanugool C; Poshyachinda M; Sopit Thamaree; Saowanee Yenrudi; Buranasiri K; Saleekul P; Dhevy Watana; Rajanee Sensirivatana; Kingwatanakul P


Nephron | 1995

Improved Renal Perfusion Prevents Disease Progression in Focal Segmental Glomerulosclerosis

Prasit Futrakul; Narisa Futrakul; Visith Sitprija; Rajanee Sensirivatana; Dhevy Watana; Pornchai Kingwatanakul


Journal of the Medical Association of Thailand Chotmaihet thangphaet | 1998

Pediatric Sarcoidosis Presenting with Hypertensive Encephalopathy

Jaakchai Jungthirapanich; Dhevy Watana; Prapai Pongprasit; Siriwan Vananukul; Laddawan Vajaragupta; Saowanee Yenrudi


American Journal of Nephrology | 1997

Subject Index Vol. 17,1997

Lionel Rostaing; Olivier Martinet; Jean-Marc Cisterne; Josette Icart; Marie-Hélène Chabannier; Dominique Durand; Ghulam Hassan Malik; Jamal Al-Wakeel; Suleiman Al-Mohaya; Ahmad Hassan Mitwalli; Riad A. Sulimani; Mohammad Shihabudin Kechrid; Hazem El Gamal; Satoru Suzuki; Hoyu Takahashi; Hirokazu Sato; Ahmed Shafik; Ghazali A. Khan; Frances I. Lewis; Manash Dasgupta; Jolanta Karpinski; Serge Jothy; Victor Radoux; Mortimer Levy; Dana Baran; Prasit Futrakul; Visith Sitprija; Saowanee Yenrudi; Makumkrong Poshyachinda; Rajanee Sensirivatana


American Journal of Nephrology | 1997

Contents, Vol. 17, 1997

Lionel Rostaing; Olivier Martinet; Jean-Marc Cisterne; Josette Icart; Marie-Hélène Chabannier; Dominique Durand; Ghulam Hassan Malik; Jamal Al-Wakeel; Suleiman Al-Mohaya; Ahmad Hassan Mitwalli; Riad A. Sulimani; Mohammad Shihabudin Kechrid; Hazem El Gamal; Satoru Suzuki; Hoyu Takahashi; Hirokazu Sato; Ahmed Shafik; Ghazali A. Khan; Frances I. Lewis; Manash Dasgupta; Jolanta Karpinski; Serge Jothy; Victor Radoux; Mortimer Levy; Dana Baran; Prasit Futrakul; Visith Sitprija; Saowanee Yenrudi; Makumkrong Poshyachinda; Rajanee Sensirivatana

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Prasit Futrakul

King Chulalongkorn Memorial Hospital

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Rajanee Sensirivatana

King Chulalongkorn Memorial Hospital

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Saowanee Yenrudi

King Chulalongkorn Memorial Hospital

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Visith Sitprija

Queen Saovabha Memorial Institute

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Narisa Futrakul

King Chulalongkorn Memorial Hospital

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Pornchai Kingwatanakul

King Chulalongkorn Memorial Hospital

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