Di Paolo S
University of Bari
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Featured researches published by Di Paolo S.
Transplantation | 2000
Di Paolo S; Antonio Schena; Luigi Morrone; Manfredi G; Giovanni Stallone; Derosa C; Alfredo Procino; Francesco Paolo Schena
BACKGROUND In rodents, CsA has been shown to affect T-cell development, giving rise to an abnormal production of mature T cells and the absence of many T-cell subsets as well as to autoimmunity. Surprisingly, only a few studies investigated the effect of the immunosuppressive drug on the immune system of the human fetus. METHODS We examined six infants born to female kidney transplant recipients who had received cyclosporine and methylprednisolone throughout their pregnancies. Peripheral blood was obtained 1 day and 2, 4, 6, and 12 months after birth, and two-color flow cytometric immunophenotyping of lymphocytes was performed. RESULTS Total T cells, as well as CD4+ and CD8+ T cells, were low at birth, but normalized thereafter. Among T-cell activation markers, the expression of CD25, the alpha chain of the interleukin-2 receptor, was below the normal range or low range throughout the study period, and HLA-DR expression was extremely low at birth and failed to increase up to 12 months. The number of total B cells was lower than normal at birth, but steeply increased over time. In contrast, B-cell subset bearing CD5 antigen was severely depleted throughout the first year of life. Total IgG concentration was significantly lower than in controls at 2 months, mainly because of subnormal levels of IgG1 and IgG3 subclasses, which remained in the low range up to 6 months. Finally, infants showed normal numbers of true natural killer (NK) cells (CD3-CD16+CD56+), whereas the expression of CD57 antigen, defining non-MHC-restricted cytotoxic lymphocytes, was barely detectable at birth and failed to increase over time, in both CD8+ and CD8- subsets. Of note, none of the infants had clinical evidence of an immunodeficient state. CONCLUSIONS continuous exposure to CsA in utero seemingly impairs T-, B-, and NK-cell development and/or maturation, and most of its effects are still apparent at 1 year, which might suggest that conventional vaccinations should be delayed in these infants.
The New England Journal of Medicine | 2005
Giovanni Stallone; Antonio Schena; Barbara Infante; Di Paolo S; Antonia Loverre; Maggio G; Elena Ranieri; Loreto Gesualdo; Francesco Paolo Schena; Giuseppe Grandaliano
Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia | 2004
Barbara Infante; Giovanni Stallone; Antonio Schena; Giuseppe Grandaliano; Di Paolo S; Francesco Paolo Schena
Journal of Nephrology | 2003
Di Paolo S; Volpe P; Giuseppe Grandaliano; Giovanni Stallone; Antonio Schena; Pantaleo Greco; Leonardo Resta; Luigi Selvaggi; Raffaele I. Cincione; Francesco Paolo Schena; Loreto Gesualdo
Journal of Nephrology | 2003
Giovanni F.M. Strippoli; Di Paolo S; Raffaele I. Cincione; Di Palma Am; Annalisa Teutonico; Giuseppe Grandaliano; Schena Fp; Loreto Gesualdo
Journal of Nephrology | 2008
Mauro Cignarelli; Di Paolo S; Loreto Gesualdo
Kidney International | 1993
Loreto Gesualdo; Elena Ranieri; Pannarale G; Di Paolo S; Francesco Paolo Schena
Thrombosis and Haemostasis | 1995
Mario Colucci; Loreto Gesualdo; Pasqualina Montemurro; Luciano Cavallo; M. Conese; Mascolo E; Elena Ranieri; Di Paolo S; Francesco Paolo Schena; Nicola Semeraro
Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia | 2004
Giovanni Stallone; Barbara Infante; Antonio Schena; Di Paolo S; Giuseppe Grandaliano; Loreto Gesualdo; Francesco Paolo Schena
Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia | 2002
Luigi Morrone; Capurso D; D'Elia F; Di Paolo S; Giuseppe Grandaliano; Marangi Al; Antonio Schena; Giovanni Stallone; Tarantino G; Gruppo di Studio Apulo-Lucano sul Trapianto Renale