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Dive into the research topics where Diane M. Retallack is active.

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Featured researches published by Diane M. Retallack.


Microbes and Infection | 1999

Molecular epidemiology, pathogenesis, and genetics of the dimorphic fungus Histoplasma capsulatum

Diane M. Retallack; Jon P. Woods

Histoplasma capsulatum, the causative agent of the most common systemic fungal infection, histoplasmosis, has become subject to increasing study in parallel with rising prevalence of human immunodeficiency. This review presents a summary of the advances made in the investigation of H. capsulatum genomics, molecular epidemiology, pathogenesis, and molecular genetics.


Infection and Immunity | 2017

The Plasmodium falciparum Cell-Traversal Protein for Ookinetes and Sporozoites as a Candidate for Preerythrocytic and Transmission-Blocking Vaccines

Diego A. Espinosa; Joel Vega-Rodríguez; Yevel Flores-Garcia; Amy R. Noe; Christian Muñoz; Russell John Coleman; Torben R. Bruck; Keith L. Haney; Alex Stevens; Diane M. Retallack; Jeffrey Allen; Thomas S. Vedvick; Christopher B. Fox; Steven G. Reed; Randall F. Howard; Ahmed M. Salman; Chris J. Janse; Shahid M. Khan; Fidel Zavala; Gabriel M. Gutierrez

ABSTRACT Recent studies have shown that immune responses against the cell-traversal protein for Plasmodium ookinetes and sporozoites (CelTOS) can inhibit parasite infection. While these studies provide important evidence toward the development of vaccines targeting this protein, it remains unknown whether these responses could engage the Plasmodium falciparum CelTOS in vivo. Using a newly developed rodent malaria chimeric parasite expressing the P. falciparum CelTOS (PfCelTOS), we evaluated the protective effect of in vivo immune responses elicited by vaccination and assessed the neutralizing capacity of monoclonal antibodies specific against PfCelTOS. Mice immunized with recombinant P. falciparum CelTOS in combination with the glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) or glucopyranosyl lipid adjuvant-liposome-QS21 (GLA-LSQ) adjuvant system significantly inhibited sporozoite hepatocyte infection. Notably, monoclonal antibodies against PfCelTOS strongly inhibited oocyst development of P. falciparum and Plasmodium berghei expressing PfCelTOS in Anopheles gambiae mosquitoes. Taken together, our results demonstrate that anti-CelTOS responses elicited by vaccination or passive immunization can inhibit sporozoite and ookinete infection and impair vector transmission.


Seminars in Respiratory Infections | 2001

Pathogenesis of Histoplasma capsulatum.

Jon P. Woods; Elizabeth L. Heinecke; Luecke Jw; Maldonado E; Ng Jz; Diane M. Retallack; Michelle M. Timmerman


Infection and Immunity | 2000

The URA5 Gene Is Necessary for Histoplasma capsulatum Growth during Infection of Mouse and Human Cells

Diane M. Retallack; Elizabeth L. Heinecke; Reta S. Gibbons; George S. Deepe; Jon P. Woods


Journal of Bacteriology | 1998

Rare Homologous Gene Targeting in Histoplasma capsulatum: Disruption of the URA5Hc Gene by Allelic Replacement

Jon P. Woods; Diane M. Retallack; Elizabeth L. Heinecke; William E. Goldman


Microbial Pathogenesis | 2000

Applying in vivo expression technology (IVET) to the fungal pathogen Histoplasma capsulatum

Diane M. Retallack; George S. Deepe; Jon P. Woods


Archive | 2008

Bacterial leader sequences for increased expression

Russell John Coleman; Diane M. Retallack; Jane C. Schneider; Thomas Martin Ramseier; Charles Douglas Hershberger; Stacey L. Lee; Sol Resnick


Archive | 2008

Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins

Diane M. Retallack; Charles H. Squires; Thomas Martin Ramseier; Russell John Coleman; Jane C. Schneider; Charles Douglas Hershberger


Archive | 2010

Production Of Recombinant Proteins Utilizing Non-Antibiotic Selection Methods And The Incorporation Of Non-Natural Amino Acids Therein

Diane M. Retallack; Lawrence C. Chew; Charles H. Squires


Gene | 1999

Transcript splicing is essential for functional Histoplasma capsulatum URA5 expression

Diane M. Retallack; Jon P. Woods

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Jon P. Woods

University of Wisconsin-Madison

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Elizabeth L. Heinecke

University of Wisconsin-Madison

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