Diego I. Gallardo

Bayesian bivariate survival analysis using the power variance function copula

Copula models have become increasingly popular for modelling the dependence structure in multivariate survival data. The two-parameter Archimedean family of Power Variance Function (PVF) copulas includes the Clayton, Positive Stable (Gumbel) and Inverse Gaussian copulas as special or limiting cases, thus offers a unified approach to fitting these important copulas. Two-stage frequentist procedures for estimating the marginal distributions and the PVF copula have been suggested by Andersen (Lifetime Data Anal 11:333–350, 2005), Massonnet et al. (J Stat Plann Inference 139(11):3865–3877, 2009) and Prenen et al. (J R Stat Soc Ser B 79(2):483–505, 2017) which first estimate the marginal distributions and conditional on these in a second step to estimate the PVF copula parameters. Here we explore an one-stage Bayesian approach that simultaneously estimates the marginal and the PVF copula parameters. For the marginal distributions, we consider both parametric as well as semiparametric models. We propose a new method to simulate uniform pairs with PVF dependence structure based on conditional sampling for copulas and on numerical approximation to solve a target equation. In a simulation study, small sample properties of the Bayesian estimators are explored. We illustrate the usefulness of the methodology using data on times to appendectomy for adult twins in the Australian NH&MRC Twin registry. Parameters of the marginal distributions and the PVF copula are simultaneously estimated in a parametric as well as a semiparametric approach where the marginal distributions are modelled using Weibull and piecewise exponential distributions, respectively.

Bimodality based on the generalized skew-normal distribution

ABSTRACT This paper focuses on the development of a new extension of the generalized skew-normal distribution introduced in Gómez et al. [Generalized skew-normal models: properties and inference. Statistics. 2006;40(6):495–505]. To produce the generalization a new parameter is introduced, the signal of which has the flexibility of yielding unimodal as well as bimodal distributions. We study its properties, derive a stochastic representation and state some expressions that facilitate moments derivation. Maximum likelihood is implemented via the EM algorithm which is based on the stochastic representation derived. We show that the Fisher information matrix is singular and discuss ways of getting round this problem. An illustration using real data reveals that the model can capture well special data features such as bimodality and asymmetry.

A simplified estimation procedure based on the EM algorithm for the power series cure rate model

ABSTRACT The family of power series cure rate models provides a flexible modeling framework for survival data of populations with a cure fraction. In this work, we present a simplified estimation procedure for the maximum likelihood (ML) approach. ML estimates are obtained via the expectation-maximization (EM) algorithm where the expectation step involves computation of the expected number of concurrent causes for each individual. It has the big advantage that the maximization step can be decomposed into separate maximizations of two lower-dimensional functions of the regression and survival distribution parameters, respectively. Two simulation studies are performed: the first to investigate the accuracy of the estimation procedure for different numbers of covariates and the second to compare our proposal with the direct maximization of the observed log-likelihood function. Finally, we illustrate the technique for parameter estimation on a dataset of survival times for patients with malignant melanoma.

A flexible cure rate model based on the polylogarithm distribution

ABSTRACT Models for dealing with survival data in the presence of a cured fraction of individuals have attracted the attention of many researchers and practitioners in recent years. In this paper, we propose a cure rate model under the competing risks scenario. For the number of causes that can lead to the event of interest, we assume the polylogarithm distribution. The model is flexible in the sense it encompasses some well-known models, which can be tested using large sample test statistics applied to nested models. Maximum-likelihood estimation based on the EM algorithm and hypothesis testing are investigated. Results of simulation studies designed to gauge the performance of the estimation method and of two test statistics are reported. The methodology is applied in the analysis of a data set.

The power piecewise exponential model

ABSTRACT In this paper an extension of the piecewise exponential distribution based on the distribution of the maximum of a random sample is considered. Properties of its density and hazard function are investigated. Maximum likelihood inference is discussed and the Fisher information matrix is identified. Results of two real data applications are reported, where model fitting is implemented by using maximum likelihood. The applications illustrate the better performance of the new distribution when compared with other recently proposed alternative models.

The Rayleigh–Lindley model: properties and applications

ABSTRACT In this paper, the Rayleigh–Lindley (RL) distribution is introduced, obtained by compounding the Rayleigh and Lindley discrete distributions, where the compounding procedure follows an approach similar to the one previously studied by Adamidis and Loukas in some other contexts. The resulting distribution is a two-parameter model, which is competitive with other parsimonious models such as the gamma and Weibull distributions. We study some properties of this new model such as the moments and the mean residual life. The estimation was approached via EM algorithm. The behavior of these estimators was studied in finite samples through a simulation study. Finally, we report two real data illustrations in order to show the performance of the proposed model versus other common two-parameter models in the literature. The main conclusion is that the model proposed can be a valid alternative to other competing models well established in the literature.

Truncated Power-Normal Distribution with Application to Non-Negative Measurements

This paper focuses on studying a truncated positive version of the power-normal (PN) model considered in Durrans (1992). The truncation point is considered to be zero so that the resulting model is an extension of the half normal distribution. Some probabilistic properties are studied for the proposed model along with maximum likelihood and moments estimation. The model is fitted to two real datasets and compared with alternative models for positive data. Results indicate good performance of the proposed model.

A clustering cure rate model with application to a sealant study

ABSTRACT In this paper, the destructive negative binomial (DNB) cure rate model with a latent activation scheme [V. Cancho, D. Bandyopadhyay, F. Louzada, and B. Yiqi, The DNB cure rate model with a latent activation scheme, Statistical Methodology 13 (2013b), pp. 48–68] is extended to the case where the observations are grouped into clusters. Parameter estimation is performed based on the restricted maximum likelihood approach and on a Bayesian approach based on Dirichlet process priors. An application to a real data set related to a sealant study in a dentistry experiment is considered to illustrate the performance of the proposed model.