Diego Pérez

Perspectives of antimony compounds in oncology

AbstractAntimony, a natural element that has been used as a drug for over more than 100 years, has remarkable therapeutic efficacy in patients with acute promyelocytic leukemia. This review focuses on recent advances in developing antimony anticancer agents with an emphasis on antimony coordination complexes, Sb (III) and Sb (V). These complexes, which include many organometallic complexes, may provide a broader spectrum of antitumoral activity. They were compared with classical platinum anticancer drugs. The review covers the literature data published up to 2007. A number of antimonials with different antitumoral activities are known and have diverse applications, even though little research has been done on their possibilities. It might be feasible to develop more specific and effective inhibitors for phosphatase-targeted, anticancer therapeutics through the screening of sodium stibogluconate (SSG) and potassium antimonyltartrate-related compounds, which are comprised of antimony conjugated to different organic moieties. For example, SSG appears to be a better inhibitor than suramin which is a compound known for its antineoplastic activity against several types of cancers.

Synthesis and Characterization of New 1,2-Disubstituted Ferrocenyl Bismuthines

Bismuthine Ph2BiFc containing the pendant arm 2-(Me2NCH2)- (1) on ferrocenyl ring was synthesized, and reaction of (1) with CH3I was carried out to obtain the monoammonium salt {[2-(Me3N+CH2)Fc]}BiPh2[I]- (2). Molecular structures of bismuthines (1) and (2) have been determined by X-ray crystallography. Compound (1) does not show hypervalent Bi-N interaction. New 1,2-disubstituted ferrocenyl bismuthines have been characterized by various physicochemical techniques.

Chlorido{1-[(dimethylamino)methyl]ferrocenyl-κ2C2,N}(tri­phenyl­stibine-κSb)palladium(II)

In the title compound, [FePdCl(C5H5)(C8H11N)(C18H15Sb)], obtained by reaction of diphenyl(N,N-dimethylaminomethylferrocenyl)stibine with sodium tetrachloridopalladate(II) in acetone, the PdII atom is coordinated in a slightly distorted square-planar geometry by a C atom of the ferrocenyl ring, and by N, Cl and Sb atoms. The Sb and N atoms are trans to each other.

Synthesis, Characterization and Crystal Structures of 1,2-Disubstituted Ferrocenyl Stibines

New 1,2-disubstituted ferrocenyl stibines containing a -CH2OR pendant arm were synthesized and characterized by various spectral and analytical methods. Nucleophilic substitution of rac-diphenyl[( 2-trimethylammoniomethylferrocen-1-yl)]stibine iodide by methanol produces compound Fc(CH2OMe)SbPh2 (1). The acetylation of diphenyl(2-dimethylaminomethylferrocen-1-yl)stibine by acetic anhydride affords compound Fc(CH2OCOCH3)SbPh2 (2), which on further reaction with sodium hydroxide affords the alcohol Fc(CH2OH)SbPh2 (3). The molecular structures of the stibines 1, 2 and 3 were determined by X-ray crystallography. None of the heterobimetallic compounds containing a -CH2OR arm shows hypervalent interactions in the solid state. By contrast, hypervalent interactions were found in ferrocenyl stibines with a -CH2NR2 pendant arm. Graphical Abstract Synthesis, Characterization and Crystal Structures of 1,2-Disubstituted Ferrocenyl Stibines