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Dive into the research topics where Dieter Waumans is active.

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Featured researches published by Dieter Waumans.


Biochemical Pharmacology | 2001

Morphine-6β-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies

Chris Ulens; Lanning Baker; Anna Ratka; Dieter Waumans; Jan Tytgat

Using heterologous expression in Xenopus laevis oocytes, we compared the potencies of morphine, morphine-6beta-glucuronide (M6G), and morphine-3-glucuronide (M3G) for cloned human mu- (hMOR), kappa- (hKOR), and delta-opioid receptors (hDOR). Each receptor subtype was individually co-expressed with heteromultimeric G-protein coupled inwardly rectifying K(+) (GIRK) channels, consisting of GIRK1 and GIRK2 subunits, and RGS4, a regulator of G-protein signaling. The two-microelectrode voltage clamp technique was used to measure the opioid receptor-activated GIRK1/GIRK2 channel responses. Compared with morphine, M6G had higher potency at the hMOR, lower potency at the hKOR, and similar potency at the hDOR, while M3G showed a 1000-fold lower and non-selective potency via opioid receptors. In contrast to naloxone, M3G did not antagonize the effects of morphine at the hMOR. We also investigated whether Trp318 and His319 provide the molecular basis for mu/delta selectivity and mu/kappa selectivity of morphinan alkaloids by mutating these residues to their corresponding residues in kappa- and delta-opioid receptors. A single-point mutation (W318L) on hMOR completely conferred delta-like potency for morphine and M6G on the mutant mu-receptor. Double mutation at Trp318 and His319 positions (Trp318Y/His319Y) only partially conferred kappa-like potency for morphine and M6G; the decrease in potency for M6G was significantly larger than for morphine. The results of our study show that both M6G and M3G are opioid receptor agonists with different potencies and that the potency of morphinan receptor ligands can be changed by selective mutations of hMOR at the Trp318 and His319 positions.


Forensic Science International | 2004

A neolignan-type impurity arising from the peracid oxidation reaction of anethole in the surreptitious synthesis of 4-methoxyamphetamine (PMA)

Dieter Waumans; Bas Hermans; Noël Bruneel; Jan Tytgat


Archive | 2013

Are bloodspots usable in postmortem forensic toxicology

Eva Cuypers; Marieke De Boeck; Anja Ledinek; Ruth Verplaetse; Dieter Waumans; Sara Loix; Arne Bonneure; Wim Van de Voorde; Jan Tytgat


Archive | 2012

Discovery of buried cadavvers using detection and analysis of volatile decomposition compounds

E. Rosier; D. Maes; Dieter Waumans; Ruth Verplaetse; Eva Cuypers; T. Ivaneanu; Jan Tytgat


toxichem | 2010

High sensitive UFLC-MS/MS analysis of fentanyl and norfentanyl in different post-mortem matrices: seven forensic cases

Ruth Verplaetse; Eva Cuypers; C. Silvestre; Dieter Waumans; Jan Tytgat


Archive | 2009

Vergelijkende analyse van post-mortem overblijfselen van menselijke en dierlijke oorsprong: perspectieven voor een toekomstig experiment

Ruth Verplaetse; Dieter Waumans; Noël Bruneel; Eva Cuypers; J. de Winne; B. Smedts; W. Van de Voorde; Jan Tytgat


Archive | 2007

Comparative analysis of post-mortem remains from human and animal origin: perspectives of a future study

Ruth Verplaetse; Dieter Waumans; Noël Bruneel; Eva Cuypers; J. de Winne; B. Smedts; W. Van de Voorde; Jan Tytgat


Archive | 2007

Concurrent appearance of vanoxerine, mCPP and 'wormazine' on the Belgian market: a case study

Ruth Verplaetse; Dieter Waumans; Noël Bruneel; Suzanne Toppet; Wim Dehaen; Jan Tytgat


Archive | 2004

Anise Oil as a Precursor for 2-Alkoxy-5-methoxybenzaldehydes

Dieter Waumans; Noël Bruneel; Jan Tytgat


Farmaceutisch Tijdschrift voor Belgie | 2004

Illegale drugs: Focus op phenylethylamines

Frank Bosmans; Dieter Waumans; Bas Hermans; Noël Bruneel; Jan Tytgat

Collaboration


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Noël Bruneel

Katholieke Universiteit Leuven

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Ruth Verplaetse

Katholieke Universiteit Leuven

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Jan Tytgat

Katholieke Universiteit Leuven

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Eva Cuypers

Katholieke Universiteit Leuven

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Jan Tytgat

Katholieke Universiteit Leuven

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Bas Hermans

Katholieke Universiteit Leuven

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Arne Bonneure

Katholieke Universiteit Leuven

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Chris Ulens

Katholieke Universiteit Leuven

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E. Rosier

Katholieke Universiteit Leuven

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Marieke De Boeck

Katholieke Universiteit Leuven

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