Dimitrios Nikas
University of Illinois at Chicago
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Journal of Neurosurgery | 2014
Dimitrios Nikas; Alexander F. Post; Asim F. Choudhri; Catherine A. Mazzola; Laura Mitchell; Ann Marie Flannery
OBJECT The objective of this systematic review is to answer the following question: Does ventricle size after treatment have a predictive value in determining the effectiveness of surgical intervention in pediatric hydrocephalus? METHODS The US National Library of Medicine PubMed/MEDLINE database and the Cochrane Database of Systematic Reviews were searched using MeSH headings and key words relevant to change in ventricle size after surgical intervention for hydrocephalus in children. An evidentiary table was assembled summarizing the studies and the quality of evidence (Classes I-III). RESULTS Six articles satisfied inclusion criteria for the evidentiary tables for this part of the guidelines. All were Class III retrospective studies. CONCLUSIONS/RECOMMENDATIon: There is insufficient evidence to recommend a specific change in ventricle size as a measurement of the effective treatment of hydrocephalus and as a measurement of the timing and effectiveness of treatments including ventriculoperitoneal shunts and third ventriculostomies. STRENGTH OF RECOMMENDATION Level III, unclear clinical certainty.
Neurosurgery | 2016
Catherine A. Mazzola; Lissa C. Baird; David F. Bauer; Alexandra D. Beier; Susan Durham; Paul Klimo; Alexander Y. Lin; Catherine McClung-Smith; Laura Mitchell; Dimitrios Nikas; Mandeep S. Tamber; Rachana Tyagi; Ann Marie Flannery
BACKGROUND No evidence-based guidelines exist for the imaging of patients with positional plagiocephaly. OBJECTIVE The objective of this systematic review and evidence-based guideline is to answer the question, Is imaging necessary for infants with positional plagiocephaly to make a diagnosis? METHODS The National Library of Medicine Medline database and the Cochrane Library were queried with the use of MeSH headings and key words relevant to imaging as a means to diagnose plagiocephaly. Abstracts were reviewed, and an evidentiary table was assembled summarizing the studies and the quality of evidence (Classes I-III). Based on the quality of the literature, a recommendation was rendered (Level I, II, or III). RESULTS A total of 42 full-text articles were selected for review. Of these, 10 were eliminated; thus, 32 full-text were manuscripts selected. There was no Class I evidence, but 2 Class II and 30 Class III studies were included. Three-dimensional cranial topographical imaging, ultrasound, skull x-rays, computed tomography, and magnetic resonance imaging were investigated. CONCLUSION Clinical examination is most often sufficient to diagnose plagiocephaly (quality, Class III; strength, Level III). Within the limits of this systematic review, the evidence suggests that imaging is rarely necessary and should be reserved for cases in which the clinical examination is equivocal. Many of the imaging studies were not designed to address the diagnostic utility of the imaging modality, and authors were actually assessing the utility of the imaging in longitudinal follow-up, not initial diagnosis. For this reason, some of the studies reviewed were downgraded in Level of Evidence. When needed, 3-dimensional cranial topographical photo, skull x-rays, or ultrasound imaging is almost always sufficient for definitive diagnosis. Computed tomography scanning should not be used to diagnose plagiocephaly, but it may be necessary to rule out craniosynostosis. The full guidelines document can be located at https://www.cns.org/guidelines/guidelines-management-patients-positional-plagiocephaly/Chapter_2.
Neurosurgery | 2016
Ann Marie Flannery; Mandeep S. Tamber; Catherine A. Mazzola; Paul Klimo; Lissa C. Baird; Rachana Tyagi; David F. Bauer; Alexandra D. Beier; Susan Durham; Alexander Y. Lin; Catherine McClung-Smith; Laura Mitchell; Dimitrios Nikas
BACKGROUND Positional plagiocephaly is a common problem seen by pediatricians, pediatric neurologists, and pediatric neurosurgeons. OBJECTIVE To create evidence-based guidelines for the treatment of pediatric positional plagiocephaly. METHODS This guideline was prepared by the Plagiocephaly Guideline Task Force, a multidisciplinary team made up of physician volunteers (clinical experts), medical librarians, and clinical guidelines specialists. The task force conducted a series of systematic literature searches of PubMed and the Cochrane Library, according to standard protocols for each topic addressed in subsequent chapters of this guideline. RESULTS The systematic literature searches returned 396 abstracts relative to the 4 main topics addressed in this guideline. The results were analyzed and are described in detail in each subsequent chapter included in this guideline. CONCLUSION Evidence-based guidelines for the management of infants with positional plagiocephaly will help practitioners manage this common disorder. The full guidelines documents can be located at https://www.cns.org/guidelines/guidelines-management-patients-positional-plagiocephaly.
Pediatric Neurosurgery | 2017
Shivani D. Rangwala; Matthew K. Tobin; Daniel M. Birk; Jonathan T. Butts; Dimitrios Nikas; Yoon S. Hahn
The anterior cingulate gyrus (ACG) is a continued focus of research as its exact role in brain function and vast connections with other anatomical locations is not fully understood. A review of the literature illustrates the role the ACG likely plays in cognitive and emotional processing, as well as a modulating role in motor function and goal-oriented behaviors. While lesions of the cingulate gyrus are rare, each new case broadens our understanding of its role in cognitive neuroscience and higher order processing. The authors present the case of an 8-year-old boy with a 1-month history of staring spells, agitated personality, and hyperphagia notable for the consumption of paper, who was found to have a 3-cm tumor in the left ACG. Following surgical resection of the tumor, his aggressive behavior and pica were ameliorated and the patient made an uneventful recovery, with no evidence of recurrence over the last 6 years since surgical resection. Here we discuss a unique behavioral presentation of pica, along with a review of the current literature, to illustrate functions of the ACG relevant to the location of the lesion.
Childs Nervous System | 2017
Darian R. Esfahani; Laura Burokas; Henry G. Brown; Yoon S. Hahn; Dimitrios Nikas
PurposeNeurenteric cysts are rare congenital remnants formed by a failure of separation between endoderm and ectoderm in utero.MethodsWe describe a case of a 7-month-old male with a large cervical neurenteric cyst presenting with intermittent neck stiffness and irritability.ResultsThis cyst was resected, recurred, and required repeat surgery. The patient’s postoperative course included aseptic meningitis and hydrocephalus requiring ventriculoperitoneal shunt and later management of tethered cord, necessitating detethering.ConclusionUnique features of this case include the presence of intermittent pain symptoms, which may be attributable to cyst filling and emptying. Hydrocephalus is an uncommon finding that may be secondary to aseptic meningitis from cyst rupture. Tethered cord is also an unusual entity that can accompany this diagnosis, warranting additional imaging work-up and monitoring.
European Journal of Pediatric Surgery Reports | 2016
Alexander Ivanov; Tibor Valyi-Nagy; Dimitrios Nikas
Infantile soft tissue tumors of the head are very rare and the majority of them are myofibromas. The authors present the case of a 1-day-old boy with a scalp tumor with several distinct histopathological features including myofibroma, hemangiopericytoma, and fibrosarcoma consistent with the diagnosis of composite infantile myofibromatosis. Genetic testing was negative for trisomy 17, translocation (12; 15), FUS, and ETV6 translocations. Despite the ominous histopathological features, the clinical course was benign. The authors review here available literature concerning current concepts of making the diagnosis of composite infantile myofibromatosis and discuss treatment options.
Journal of Neurosurgery | 2014
Ann Marie Flannery; Catherine A. Mazzola; Paul Klimo; Ann-Christine Duhaime; Lissa C. Baird; Mandeep S. Tamber; David D. Limbrick; Dimitrios Nikas; Joanna Kemp; Alexander F. Post; Kurtis I. Auguste; Asim F. Choudhri; Laura Mitchell; Debby Buffa
Neurosurgery | 2016
Mandeep S. Tamber; Dimitrios Nikas; Alexandra D. Beier; Lissa C. Baird; David F. Bauer; Susan Durham; Paul Klimo; Alexander Y. Lin; Catherine A. Mazzola; Catherine McClung-Smith; Laura Mitchell; Rachana Tyagi; Ann Marie Flannery
Neurosurgery | 2016
Paul Klimo; Patrick Ryan Lingo; Lissa C. Baird; David F. Bauer; Alexandra D. Beier; Susan Durham; Alexander Y. Lin; Catherine McClung-Smith; Laura Mitchell; Dimitrios Nikas; Mandeep S. Tamber; Rachana Tyagi; Catherine A. Mazzola; Ann Marie Flannery
Neurosurgery | 2016
Lissa C. Baird; Paul Klimo; Ann Marie Flannery; David F. Bauer; Alexandra D. Beier; Susan Durham; Alexander Y. Lin; Catherine McClung-Smith; Laura Mitchell; Dimitrios Nikas; Mandeep S. Tamber; Rachana Tyagi; Catherine A. Mazzola