Dinesh K. Patel

Structural, spectroscopic, and biological studies of N,O donor Schiff base copper(II) complexes

The Schiff bases (L1 and L2) and their complexes [Cu(L)2] (L1 = N-[(1)-1-(4-methylphenyl)ethylidene]benzolhydrazide and L2 = N-[(1)-1-(2-methoxyphenyl)ethylidene]benzolhydrazide) have been prepared and characterized by elemental analysis, magnetic, and conductivity measurements. Crystal structure of the two complexes determined by single crystal X-ray analysis shows distorted square planar CuN2O2 coordination. Electron paramagnetic resonance spectra of these complexes in frozen DMSO show a signal at g ca 2. The trend in g-value (g ‖ > g ⊥ > 2.0023) suggests that the unpaired electron on copper(II) has character. The superoxide dismutase and biological (antimicrobial) activities of these complexes have also been screened.

Carboxylate-bridged copper(II) complexes: synthesis, crystal structures, and superoxide dismutase activity

Two copper(II) complexes, [Cu2(μ-benzoato)(L1)2]NO3·2H2O (1) and [Cu2(μ-succinato)(L2)2(H2O)]ClO4 (2), have been synthesized, where L1 = N′-[(E)-phenyl(pyridin-2-yl)methylidene]benzoylhydrazone and L2 = N′-[(E)-pyridin-2-ylmethylidene]benzoylhydrazone. These complexes were characterized including by single-crystal X-ray diffraction studies. The copper is five-coordinate in 1 while in 2 one copper is five-coordinate and the other is six-coordinate. Electrochemical behavior of these complexes was measured by cyclic voltammetry. The conproportionation equilibrium constants (Kcon) for both complexes have been estimated. The superoxide dismutase (SOD) activities of 1 and 2 were measured by nitro blue tetrazolium assay. Complex 1 has better SOD activity than 2.

Synthesis, spectral and structural study of sulfur-containing copper(II) complexes

A series of four new copper(II) complexes [Cu(H2L)(L1)] 1, [Cu(H2L)(PMDT)] 2, [Cu(H2L)(Dien)] 3 and [Cu(H2L)(L2)] 4 have been synthesized by template condensation (H2L=thiodiglycolic acid, L1=N-[(1)-1-(4-methylphenyl)ethylidene]benzohydrazide, PMDT=N,N,N′,N′,N ′′-pentamethyldiethylene- triamine, Dien=diethylenetriamine L2=N-[(1)-pyridin-2-ylmethylidene]benzohydrazide). The bonding and stereochemistry of the complexes have been characterized by molar conductance, elemental analysis, magnetic susceptibility, infrared, UV–visible, electron paramagnetic resonance structural studies and electrochemical studies. g-Values were calculated for all complexes in polycrystalline form as well as in DMSO solution. The magnetic and spectral data indicate square pyramidal geometry for 1 and octahedral geometry for 2–4 complexes. Cyclic voltammograms for all the complexes are similar and involve two irreversible redox processes. Their biological properties have also been studied. The thio complexes show more antibacterial activity than the controlled one. The antibacterial activities of the compounds have also been tested against Escherichia coli with different concentrations.

Design, synthesis, and characterization of a series of biologically active copper(II) Schiff-base coordination compounds

Four Schiff-base copper(II) complexes, [Cu(L1)(Phen)(H2O)](NO3)2 (1), [Cu(L1)(bipy)(H2O)](ClO4)(H2O)(NO3) (2), [Cu(L1)(Dien)](ClO4)2(H2O) (3), and [Cu(L1)(ImH)(H2O)](ClO4) (4) (L1  = N-[(1)-pyridin-2-ylmethylidene]benzohydrazide, Phen = 1,10-phenanthroline, bipy = 2,2′-bipyridine, Dien = diethylenetriamine, ImH = imidazole), have been synthesized and characterized using various physico-chemical techniques. L1 is coordinated to copper(II) neutral and uninegatively charged tridentate chelating agent via the azomethine nitrogen, pyridine nitrogen, and carbonyl oxygen. The copper(II) complexes are paramagnetic with octahedral stereochemistry. The crystal structures of the complexes reveal the presence of structure consisting of a tridentate N, N, O donor Schiff base, tridentate NNN donor polyamine or N, N donor heterocyclic base and the copper(II) center. In 1, 2, and 4, water is present as a coordinating molecule whereas in 2 and 4 it is also present as lattice water. In discrete monomeric species all complexes show significant hydrogen-bonding interactions. H-bridges are also present in the solid state structure. Complexes 1–4 effectively catalyze the dismutation of superoxide ( ) in alkaline nitro blue tetrazolium assay and IC50 values were determined. The susceptibility of certain strains of bacteria toward the precursors L1 and their complexes were also evaluated.

Synthesis, characterization, and superoxide dismutase activity of copper(II) complexes with bidentate ligands

Two new copper(II) complexes, [Cu(BH)(bipy)](ClO4)2(H2O)2 (1) and [Cu(BH)2(NO3)2] (2) (BH = benzoylhydrazine, bipy = 2,2′-bipyridine), have been synthesized and characterized. X-ray crystallographic analysis shows the copper to be four- and six-coordinate in the complexes. The magnetic and spectroscopic data indicate a distorted square-planar geometry for 1, while 2 is assigned a distorted octahedral geometry. The electron paramagnetic resonance spectra indicate a ground state (g ‖ > g ⊥ > 2.0023). Both complexes display quasireversible redox waves due to Cu(II)/Cu(I) reduction. The superoxide dismutase-mimetic activity of the complexes was investigated by nitro blue tetrazolium chloride DMSO assay.