Dino Alberto Mattucci

A population-based study of cancer incidence in solid organ transplants from donors at various risk of neoplasia

A population-based cohort study of recipients of organs from donors with a recognized history or active cancer has been conducted by linking the Italian National Registry of Transplanted Patients and the National Registry of Donors with Neoplasia Risk. Between 2002 and 2004, 8,198 solid organ transplants have been performed in Italy, 108 of them with organs from 59 cadaveric donors with various risk of neoplasia. There were two reported cases of nonmelanoma skin cancer during the follow up of the transplanted patients, which lasted 27.6±11.3 months (234 patient-years). In our study, recipients of organs from donors with various degree of neoplasia risk are exposed to a low risk of cancer transmission.

Discrete Simulations of Cadaver Kidney Allocation Schemes

The thesis of this study is that the use of discrete simulations is the most appropriate instrument to support the definition of any organs allocation procedure. We studied the influence of recipient pool size on the probability of obtaining a good match grade and the exchange rate between regional and/or interregional organizations for two different hypothesis of national allocation schemes. We also showed the potential of simulation methods at assessing the most appropriate adjustments for the optimization of any allocation scheme.