Dirk Kosemund
Bayer
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Publication
Featured researches published by Dirk Kosemund.
ChemMedChem | 2017
Ulrich Lücking; Arne Scholz; Philip Lienau; Gerhard Siemeister; Dirk Kosemund; Rolf Bohlmann; Hans Briem; Ildiko Terebesi; Kirstin Meyer; Katja Prelle; Karsten Dr Denner; Ulf Bömer; Martina Schäfer; Knut Eis; Ray Valencia; Stuart Ince; Franz von Nussbaum; Dominik Mumberg; Karl Ziegelbauer; Bert Klebl; Axel Choidas; Peter Nussbaumer; Matthias Baumann; Carsten Schultz-Fademrecht; Gerd Rühter; Jan Eickhoff; Michael Brands
Selective inhibition of exclusively transcription‐regulating PTEFb/CDK9 is a promising new approach in cancer therapy. Starting from lead compound BAY‐958, lead optimization efforts strictly focusing on kinase selectivity, physicochemical and DMPK properties finally led to the identification of the orally available clinical candidate atuveciclib (BAYu20051143572). Structurally characterized by an unusual benzyl sulfoximine group, BAYu20051143572 exhibited the best overall profile inu2005vitro and inu2005vivo, including high efficacy and good tolerability in xenograft models in mice and rats. BAYu20051143572 is the first potent and highly selective PTEFb/CDK9 inhibitor to enter clinical trials for the treatment of cancer.
Archive | 2011
Marcus Koppitz; Ulrich Klar; Rolf Jautelat; Dirk Kosemund; Rolf Bohlmann; Benjamin Bader; Philip Lienau; Gerhard Siemeister
Archive | 2015
Ulrich Lücking; Dirk Kosemund; Arne Scholz; Philip Lienau; Gerhard Siemeister; Ulf Bömer; Rolf Bohlmann
Archive | 2012
Ulrich Lücking; Dirk Kosemund; Arne Scholz; Philip Lienau; Gerhard Siemeister; Ulf Bömer; Rolf Bohlmann
Archive | 2012
Ulrich Lücking; Rolf Bohlmann; Arne Scholz; Gerhard Siemeister; Mark Jean Gnoth; Ulf Bömer; Dirk Kosemund; Philip Lienau; Gerd Rühter; Carsten Schultz-Fademrecht
Archive | 2011
Tim Wintermantel; Carsten Möller; Ulrich Bothe; Reinhard Nubbemeyer; Ludwig Zorn; Dirk Kosemund; Laak Antonius Ter; Rolf Bohlmann; Lars Wortmann; Donald Bierer
Archive | 2011
Marcus Koppitz; Ulrich Klar; Rolf Jautelat; Dirk Kosemund; Rolf Bohlmann; Benjamin Bader; Philip Lienau; Gerhard Siemeister
Archive | 2016
Ulrich Lücking; Dirk Kosemund; Arne Scholz; Philip Lienau; Gerhard Siemeister; Ulf Bömer; Rolf Bohlmann
Archive | 2015
Marcus Koppitz; Ulrich Klar; Rolf Jautelat; Dirk Kosemund; Rolf Bohlmann; Benjamin Bader; Philip Lienau; Gerhard Siemeister
Archive | 2012
Ulrich Klar; Marcus Koppitz; Duy Nguyen; Dirk Kosemund; Roland Neuhaus; Gerhard Siemeister
