Doe Young Kim
Ewha Womans University
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The Korean Journal of Internal Medicine | 1999
Han Chu Lee; Sung Ae Jung; Hye Kyung Jung; Sun Young Yi; Doe Young Kim; Il Hwan Moon; Sung Su Park
Objectives The hepatotoxicity of acetaminophen is not a result of the parent compound but is mediated by its reactive metabolite N-acetyl-p-benzoquinone imine. Cytochrome P4502E1 (CYP2E1) is the principal enzyme of this biotransformation, which accounts for approximately 52% of the bioactivation in human microsomes. Recently, chlormethiazole, a sedative drug, is reported to be an efficient inhibitor of CYP2E1 activity in human beings. In this study we wished to evaluate whether chlormethiazole, an inhibitor of CYP2E1, could prevent acetaminophen-induced liver injury in mice. Methods Acetaminophen, at doses ranging from 200 to 600 mg/kg, was injected into the peritoneum of female C57BL/6 inbred mice fasted for four hours. Chlormethiazole (60 mg/kg) or 5% dextrose water was given 30 min before or 2 h after acetaminophen. Serum aminotransferase activities, histologic index score, survival rate and hepatic malondialdehyde levels were compared. Results Pretreatment with chlormethiazole 30 min before 400 mg/kg of acetaminophen completely inhibited acetaminophen-induced liver injury (median 118.5 U/L, range 75 to 142 vs. 14070 U/L, range 5980 to 27680 for AST; 49 U/L, range 41 to 64 vs. 15330 U/L, range 13920 to 15940 for ALT). In mice receiving chlormethiazole 2 h after acetaminophen, the mean AST and ALT levels were also less elevated, reaching only 20% of the value of acetaminophen-only group. These protective effects were confirmed histologically. Whereas more than 50% of mice died at 500 mg/kg of acetaminophen, all the mice pretreated with chlormethiazole survived at the same dose. Conclusion Chlormethiazole effectively reduces acetaminophen-induced liver injury in mice. Further studies are needed to assess its role in humans.
The Korean Journal of Internal Medicine | 2003
Hye Kyung Jung; Doe Young Kim; Il Hwan Moon
Yonsei Medical Journal | 2003
Hye Kyung Jung; Doe Young Kim; Il Hwan Moon; Young Sun Hong
Yonsei Medical Journal | 1999
Doe Young Kim; Jin Young Baek
The Korean Journal of Internal Medicine | 2002
Doe Young Kim; Michael Camilleri
Yonsei Medical Journal | 1994
Doe Young Kim; Won Ho Kim; Jin Kyung Kang; In Suh Park; Oh Hun Kwon
Korean Journal of Gastrointestinal Endoscopy | 2004
Chang Yoon Ha; Hye Kyung Jung; Jung Hwa Ryu; Hae Sun Jung; Gun Woo Pyun; Doe Young Kim; Il Hwan Moon; Min Sun Cho
The Korean Journal of Internal Medicine | 1989
Jae Bock Chung; Dong Kyoon Chung; Doe Young Kim; Kwang Hyub Han; Young Myung Moon; Jin Kyung Kang; In Suh Park; Heung Jai Choi; Jong Tae Lee; Hyun Sik Yoo
Korean Journal of Gastrointestinal Endoscopy | 2003
Ji Yoon Cho; Hye Kyung Jung; Doe Young Kim; Il Hwan Moon; Min Sun Cho
The Ewha Medical Journal | 1999
Doe Young Kim