Domenica Di Bello
University of Pisa
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Featured researches published by Domenica Di Bello.
Poultry Science | 2014
Michele Vanni; Valentina Meucci; Rosalba Tognetti; P. Cagnardi; Clara Montesissa; Alessandra Piccirillo; Anna Maria Rossi; Domenica Di Bello; Luigi Intorre
Escherichia coli are a common inhabitant of the gastrointestinal tract of mammals and birds; nevertheless, they may be associated with a variety of severe and invasive infections. Whereas fluoroquinolones (FQ) have been banned in the United States for use in poultry production, the use of these antimicrobials in poultry husbandry is still possible in the European Union, although with some restrictions. The aim of this study was to investigate the FQ resistance of 235 E. coli isolates recovered from chickens and turkeys. Minimum inhibitory concentrations were determined by a microdilution method, whereas mutations in the quinolone resistance-determining regions of the target genes, gyrA and parC, were detected by a PCR-based method. High resistance rates (>60%) were observed for nalidixic acid, flumequine, and difloxacin, whereas resistance to ciprofloxacin, danofloxacin, enrofloxacin, marbofloxacin, and sarafloxacin was less frequently reported (<40%). Sixty-four isolates (27.2%) showed full susceptibility toward the tested FQ, but 57 isolates (24.2%) were resistant to all tested FQ. The remaining 114 E. coli isolates (48.5%) were grouped in 5 different resistance patterns. Isolates resistant only to flumequine or nalidixic acid or both possessed 1 gyrA mutation, whereas isolates with further resistance to enrofloxacin, difloxacin, danofloxacin, and sarafloxacin had in addition 1 or 2 parC substitutions. Two gyrA mutations coupled with 1 substitution in parC were detected in isolates resistant to all tested FQ. The number of mutations and their correlation with the in vitro activity of FQ reflected the currently accepted model, according to which a single gyrA substitution is associated with resistance or decreased susceptibility to older quinolones, whereas further gyrA or parC substitutions are needed for a higher level of resistance.
Leukemia Research | 2012
Alessandro Martino; Gabriele Buda; Valentina Maggini; Francesco Lapi; Antonella Lupia; Domenica Di Bello; Enrico Orciuolo; Sara Galimberti; Roberto Barale; Mario Petrini; Anna Maria Rossi
Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.
Aquatic Toxicology | 2005
E Vaccaro; Valentina Meucci; Luigi Intorre; Giulio Soldani; Domenica Di Bello; Vincenzo Longo; Pier Giovanni Gervasi; Carlo Pretti
Aquatic Toxicology | 2007
Domenica Di Bello; E Vaccaro; Vincenzo Longo; Francesco Regoli; Marco Nigro; Maura Benedetti; Pier Giovanni Gervasi; Carlo Pretti
Journal of Veterinary Pharmacology and Therapeutics | 2007
Luigi Intorre; Michele Vanni; Domenica Di Bello; Carlo Pretti; Valentina Meucci; Rosalba Tognetti; Giulio Soldani; G. Cardini; O. Jousson
Veterinary Microbiology | 2007
O Jousson; Domenica Di Bello; Michele Vanni; G. Cardini; Giulio Soldani; Carlo Pretti; Luigi Intorre
Fems Microbiology Letters | 2007
O Jousson; Domenica Di Bello; Elena Donadio; Antonio Felicioli; Carlo Pretti
Javma-journal of The American Veterinary Medical Association | 2007
Luigi Intorre; Valentina Meucci; Domenica Di Bello; Gianfranca Monni; Giulio Soldani; Carlo Pretti
Journal of Veterinary Pharmacology and Therapeutics | 2006
Luigi Intorre; Michele Vanni; Domenica Di Bello; Carlo Pretti; Anna Pasquini; Rosalba Tognetti; Giulio Soldani; G. Cardini; O Jousson
Diseases of Aquatic Organisms | 2005
O Jousson; Carlo Pretti; Domenica Di Bello; Anna Maria Cognetti-Varriale