Domenico Maione
GlaxoSmithKline
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Publication
Featured researches published by Domenico Maione.
Scientific Reports | 2018
M. Giuliani; Erika Bartolini; Barbara Galli; Laura Santini; P. Lo Surdo; Francesca Buricchi; M. Bruttini; B. Benucci; N. Pacchiani; L. Alleri; D. Donnarumma; Werner Pansegrau; I. Peschiera; Ilaria Ferlenghi; Roberta Cozzi; Nathalie Norais; Marzia Monica Giuliani; Domenico Maione; M Pizza; Rino Rappuoli; Oretta Finco; Vega Masignani
Abstract4CMenB is the first broad coverage vaccine for the prevention of invasive meningococcal disease caused by serogroup B strains. To gain a comprehensive picture of the antibody response induced upon 4CMenB vaccination and to obtain relevant translational information directly from human studies, we have isolated a panel of human monoclonal antibodies from adult vaccinees. Based on the Ig-gene sequence of the variable region, 37 antigen-specific monoclonal antibodies were identified and produced as recombinant Fab fragments, and a subset also produced as full length recombinant IgG1 and functionally characterized. We found that the monoclonal antibodies were cross-reactive against different antigen variants and recognized multiple epitopes on each of the antigens. Interestingly, synergy between antibodies targeting different epitopes enhanced the potency of the bactericidal response. This work represents the first extensive characterization of monoclonal antibodies generated in humans upon 4CMenB immunization and contributes to further unraveling the immunological and functional properties of the vaccine antigens. Moreover, understanding the mechanistic nature of protection induced by vaccination paves the way to more rational vaccine design and implementation.
Archive | 2011
Domenico Maione; Daniela Rinuado
Archive | 2016
Francesco Berti; Roberta Cozzi; Guido Grandi; Domenico Maione; Immaculada Margarit y Ros; Daniela Cira Rinaudo
Archive | 2014
Francesca Abate; Enrico Malito; Roberta Cozzi; Paola Lo Surdo; Domenico Maione; Matthew J. Bottomley
Archive | 2013
Domenico Maione; Y Ros Immaculada Margarit; Roberta Cozzi; Cira Daniela Rinaudo; Maddalena Lazzarin; Francesca Zerbini
Archive | 2011
Guido Grandi; Domenico Maione; Daniela Rinuado
Archive | 2011
Guido Grandi; Domenico Maione; Cira Daniela Rinuado
Archive | 2009
Y Ros Immaculada Margarit; Guido Grandi; John L. Telford; Domenico Maione
Archive | 2007
Domenico Maione; Nathalie Norais; Guido Grandi
Archive | 2005
John L. Telford; Guido Grandi; Peter Lauer; Marirosa Mora; Immaculada Margarit Y Ros; Domenico Maione; Guiliano Bensi; Daniela Rinaudo; Vega Masignani; Michelle Barocchi; Rino Rappuloi