Dominic Lam

Psychosocial family intervention in schizophrenia: a review of empirical studies

This paper reviews the recent empirical studies on psychosocial family intervention in schizophrenia. Six family educational intervention studies and five more intensive family work studies with 2-year follow-up have been included. A series of questions is asked relating to the effects of such interventions, the efficacy of the different educational models, the active ingredients of these multi-component treatment packages, and the contribution of this new generation of studies to our understanding of the mechanisms through which these interventions work. Suggestions for further research are made. Finally, from the published manuals, the common components of these diverse, multi-component treatment packages of different family-intervention studies are identified.

Rumination, mood and social problem-solving in major depression.

BACKGROUND Ruminating when depressed is thought to lower mood and impair problem-solving, while distraction is thought to alleviate mood and assist problem-solving. The present study investigates each of these proposals using both naturally occurring and experimentally induced rumination and distraction in a sample of patients with major depression. METHOD Thirty-six patients with major depression and 36 control participants were randomly allocated to either a rumination or distraction induction condition. Levels of trait rumination and distraction were measured at baseline, mood and problem-solving were measured before and after the inductions. RESULTS In terms of trait measures, depressed patients with higher levels of trait rumination reported poorer mood and gave less effective problem solutions than those who were less ruminative. Trait distraction was not associated with mood or problem-solving. In terms of induced responses, depressed patients who were made to ruminate experienced a deterioration in their mood and gave poorer problem solutions. For those receiving the distraction induction, mood improved in all patients and problem-solving improved in patients who were not naturally ruminating at a high level. Neither induction had an impact on mood or problem-solving in control participants. CONCLUSIONS Treatment for depression associated with adverse life events may need to target rumination as well as problem-solving deficits if interventions are to be effective. The differential effects of self-applied versus experimentally induced distraction require further investigation. Future research will need to consider that high levels of trait rumination may interfere with the impact of experimental inductions.

Prodromes, coping strategies and course of illness in bipolar affective disorder--a naturalistic study.

BACKGROUND Psychosocial interventions for bipolar patients often include teaching patients to recognize prodromal symptoms and tackle them early. This prospective study set out to investigate which bipolar prodromal symptoms were reported frequently and reliably over a period of 18 months. Furthermore, we have also investigated which types of coping strategies were related to good outcome. METHOD Forty bipolar patients were interviewed for their bipolar prodromal symptoms and their coping strategies at recruitment and 18 months later. Patients were also assessed as to whether they had experienced relapses. RESULTS Bipolar patients were able to report bipolar prodromal symptoms reliably. Mania prodromal symptoms tended to be behavioural symptoms. A quarter of patients reported difficulties in detecting depression prodromes, which tended to be more diverse and consisted of a mix of behavioural, cognitive and somatic symptoms. Significantly fewer patients who reported the use of behavioural coping strategies to curb excessive behaviour during the mania prodromal stage experienced a manic episode. Similarly, significantly fewer patients who reported the use of behavioural coping strategies experienced depression relapses. How well patients coped with mania prodromes predicted bipolar episodes significantly when the mood levels at baseline were controlled. Ratings of how well subjects coped with mania prodromal symptoms also predicted manic symptoms significantly at T2 when manic symptom at T1 was controlled. CONCLUSION Our study suggests that bipolar patients are able to report prodromal symptoms reliably. It is advisable to teach patients to monitor their moods systematically and to promote good coping strategies.

Stigma and self-esteem in manic depression: an exploratory study

BACKGROUND As part of a larger study on coping styles in manic depressive patients, it was felt that self-esteem and stigmatisation, two areas that have received little attention in connection with this illness, warranted investigation. METHOD A questionnaire on self-esteem and feelings of stigmatisation was piloted. The rationale of the questionnaire is explained and data on its reliability and validity are presented. RESULTS This pilot study suggests a relationship between mood and self-esteem, while feelings of stigmatisation seem to be relatively independent of mood. However, some relationship between self-esteem and stigmatisation is suggested. LIMITATIONS This study focused on an atypical group of patients, and the questionnaire had never been used before. For this reason, the results can be best seen as suggesting further research. CONCLUSIONS We believe that issues of self-esteem and stigmatisation can have considerable clinical significance in this client group. For this reason, we hope this paper will stimulate interest in these areas.

Response style, interpersonal difficulties and social functioning in major depressive disorder

BACKGROUND It is postulated that depressed patients who engaged in self-focused rumination on their depressive symptoms may experience more hopelessness, more interpersonal distress and poorer social functioning while patients who distract themselves may experience less severe hopelessness and better social functioning. METHOD One-hundred and nine outpatients suffering from DSM-IV (APA, 1994) major depressive disorders filled in questionnaires that mapped into their response style to depression, hopelessness and interpersonal style. They were also interviewed for their levels of social functioning. RESULTS Rumination was associated with higher levels of depression and distraction was associated with lower levels of depression. Furthermore when levels of depression and gender were controlled for, rumination contributed to higher levels of hopelessness and distraction contributed to lower levels of hopelessness. Both rumination and levels of depression contributed significantly to higher levels of interpersonal distress when gender was controlled for. Ruminators were rated to have significantly more severe problems in intimate relationships while distractors were rated to have significantly higher social functioning. CONCLUSION Our study suggests the importance of teaching patients techniques to distract themselves. This could prevent patients from getting into a vicious cycle of self-absorption and increased levels of hopelessness, finding it hard to interact with people in their social network and neglecting their intimate relationships.

A preliminary study of autobiographical memory in remitted bipolar and unipolar depression and the role of imagery in the specificity of memory.

Autobiographical memory was investigated in a sample of 19 individuals with remitted bipolar affective disorder and a community sample of 16 individuals with remitted unipolar depression who had similar low levels of current symptoms. Each participant was prompted to recall one positive memory and one negative memory, to rate it on several scales, and to describe it in detail. Relative to the remitted unipolar group, the remitted bipolar group reported more general than specific negative memories and more frequent recollections of the negative memory during their everyday life. Across the sample, 95% of all specific memories involved a mental image, whereas only 56% of all general memories involved a mental image, suggesting a role of imagery in the retrieval of a specific memory. Characteristic examples of memories are provided. These results are preliminary yet they suggest that patients with bipolar disorder in remission may show memory characteristics that are often associated with symptomatic unipolar depression.

Induced mood change and dysfunctional attitudes in remitted bipolar I affective disorder.

This study investigated the possibility that, in remitted bipolar I affective disorder, dysfunctional attitudes are mood-state dependent. Participants were 120 individuals with remitted bipolar I disorder, remitted unipolar depression, or no history of affective disorder. The Dysfunctional Attitudes Scale (DAS; Weissman, 1979) was completed before and after positive or negative mood challenge. Following mood increase, the bipolar group changed significantly less in DAS total score than did the other 2 groups, and in goal-striving and achievement attitudes relative to the unipolar group. These findings did not provide clear support for the mood-state dependency theory in bipolar disorder, arguing instead for the presence in bipolar I disorder of dysfunctional cognitions that show characteristic resilience in the face of minor positive mood increase.

A pilot study of positive mood induction in euthymic bipolar subjects compared with healthy controls

BACKGROUND Demonstrating differences between euthymic bipolar subjects and healthy controls in response to positive (happy) mood induction may help elucidate how mania evolves. This pilot study evaluates the Go task in a reward paradigm as a method for inducing a happy mood state and compares the response of euthymic bipolar subjects and healthy controls. METHOD The Sense of Hyperpositive Self Scale, the Tellegen positive and negative adjectives, the Global-Local task and a visual analogue scale for measuring positive affect were administered to 15 euthymic bipolar subjects and 19 age-and-sex-matched healthy control subjects before and after they had performed the Go task in a reward paradigm. RESULTS Significant differences were found between subjects and controls on several measures at each time-point but there were no differences across the groups across time except for the visual analogue scales, where subjects had a more sustained duration in self-reported happiness compared with controls. CONCLUSIONS This pilot study has shown that a positive affect can be induced in bipolar subjects and controls which can be demonstrated by changes in scores on several tasks. However, only the visual analogue scales showed a significant difference between cases and controls over time. Such tests may prove valuable in furthering understanding about the evolution of manic mood states.

The development and validation of the coping inventory for prodromes of mania.

This study described the construction and validation of the Coping Inventory for Prodromes of Mania (CIPM)-a newly developed instrument aimed at assessing how manic depressive sufferers dealt with their prodromes of mania. Two hundred and six subjects completed a 40-item measure of coping responses to prodromes of mania, a measure of social functioning and a mood measure. The CIPM yielded four empirically derived subscales: stimulation reduction, problem-directed coping, seeking professional help, denial or blame. All of these subscales provided good reliability and acceptably high internal consistency data. There was also some evidence of good validity of the CIPM.

The effect of positive mood induction on emotional processing in euthymic individuals with bipolar disorder and controls

BACKGROUND Many studies have used negative mood induction techniques to investigate the effect of emotional state on cognitive performance but positive mood induction paradigms have been used less frequently. The objective of this study was to investigate the effect of positive mood induction on emotional processing in euthymic individuals with bipolar disorder (BD) and controls. METHOD Previously, we reported that positive mood induction using a novel technique based on feedback produced a longer-lasting effect in euthymic individuals with BD than controls (Farmer et al. 2006). Here we report the effect of mood induction on two tests of emotional processing, the Affective Go/No-go test (AGNG) and the Cambridge Gamble task (CGT), on which BD patients in the manic phase differ in their performance from controls. RESULTS Following positive mood induction, bipolar cases exhibited a positive emotional bias on the AGNG and performed more slowly than controls on the CGT, particularly when making more difficult decisions. CONCLUSIONS These data confirm that positive mood induction is more effective in individuals with BD than controls. They also suggest that alterations in decision making and attentional biases occur even with transient and subtle changes in mood in bipolar disorder.