Don C. DeJongh

A mass spectral investigation of derivatives of kanamycin A

Abstract The high and low resolution mass spectra of the N-acetyl-N,O-methyl and N-acetyl-O-trimethylsilyl derivatives of kanamycin A have been determined and interpreted, along with those of deuterated analogs under conditions of electron impact. In addition, the chemical ionization mass spectrum of the N-acetyl-N,O-methyl derivative is presented. The use of these spectra for recognizing structural features, such as the sequence of the sugar units, is discussed. The characteristics of the two types of derivatives are compared. The value of the chemical ionization spectrum and the complementary nature of the data obtained from it are emphasized.