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Dive into the research topics where Donald A. Gailey is active.

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Featured researches published by Donald A. Gailey.


Current Biology | 2006

Isoform-Specific Control of Male Neuronal Differentiation and Behavior in Drosophila by the fruitless Gene

Jean-Christophe Billeter; Adriana Villella; Jane B. Allendorfer; Anthony J. Dornan; Michael Richardson; Donald A. Gailey; Stephen F. Goodwin

BACKGROUND How the central nervous system (CNS) develops to implement innate behaviors remains largely unknown. Drosophila male sexual behavior has long been used as a model to address this question. The male-specific products of fruitless (fru) are pivotal to the emergence of this behavior. These putative transcription factors, containing one of three alternative DNA binding domains, determine the neuronal substrates for sexual behavior in male CNS. RESULTS We isolated the first fru coding mutation, resulting in complete loss of one isoform. At the neuronal level, this isoform alone controls differentiation of a male-specific muscle and its associated motorneuron. Conversely, a combination of isoforms is required for development of serotonergic neurons implicated in male copulatory behavior. Full development of these neurons requires the male-specific product of doublesex, a gene previously thought to act independently of fru. At the behavioral level, missing one isoform leads to diminished courtship behavior and infertility. We achieved the first rescue of a distinct fru behavioral phenotype, expressing a wild-type isoform in a defined subset of its normal expression pattern. CONCLUSION This study exemplifies how complex behaviors can be controlled by a single locus through multiple isoforms regulating both developmental and physiological pathways in different neuronal substrates.


Insect Molecular Biology | 1997

Reassessment of 79B actin gene expression in the abdomen of adult Drosophila melanogaster.

Saiyou Ohshima; C. Villarimo; Donald A. Gailey

The expression pattern of the 79B actin gene in Drosophila melanogaster has been inferred previously by means of a reporter gene in which 79B actin promoter sequences drive the lacZ coding sequences. Although the 79B actin gene is expressed primarily in muscles of the thorax and first abdominal segment of the adults of both sexes, expression in the remaining abdominal segments appears limited to the male genital muscles and the male‐specific Muscle of Lawrence (MOL). This reported abdominal expression pattern has been reassessed. By varying parameters of tissue preparation and lacZ reporter gene detection, expression of the 79B actin gene has been revealed in most dorsal abdominal longitudinal fibres and genital muscles of both females and males. These new results suggest that there are differences in the level of 79B actin gene expression among the various abdominal muscles of both sexes, and that abdominal expression is not limited primarily to male sex structures.


Genetics | 1997

Extended Reproductive Roles of the Fruitless Gene in Drosophila Melanogaster Revealed by Behavioral Analysis of New Fru Mutants

Adriana Villella; Donald A. Gailey; Barbra Berwald; Saiyou Ohshima; Phillip T. Barnes; Jeffrey C. Hall


Genetics | 2001

Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless.

Anuranjan Anand; Adriana Villella; Lisa C. Ryner; Troy Carlo; Stephen F. Goodwin; Ho-Juhn Song; Donald A. Gailey; Ana Morales; Jeffrey C. Hall; Bruce S. Baker; Barbara J. Taylor


Genetics | 1982

MALE COURTSHIP IN DROSOPHILA: THE CONDITIONED RESPONSE TO IMMATURE MALES AND ITS GENETIC CONTROL

Donald A. Gailey; F. Rob Jackson; Richard W. Siegel


Molecular Biology and Evolution | 2006

Functional Conservation of the fruitless Male Sex-Determination Gene Across 250 Myr of Insect Evolution

Donald A. Gailey; Jean-Christophe Billeter; Jim H. Liu; Frederick Bauzon; Jane B. Allendorfer; Stephen F. Goodwin


Genetics | 1985

REDUCED REPRODUCTIVE SUCCESS FOR A CONDITIONING MUTANT IN EXPERIMENTAL POPULATIONS OF DROSOPHILA MELANOGASTER

Donald A. Gailey; Jeffrey C. Hall; Richard W. Siegel


Proceedings of the National Academy of Sciences of the United States of America | 1997

The muscle of Lawrence in Drosophila: A case of repeated evolutionary loss

Donald A. Gailey; Saiyou Ohshima; Sabrina J.-M. Santiago; Jason M. Montez; André R. Arellano; Josephine Robillo; Cynthia A. Villarimo; Langdon Roberts; Eric Fine; Adriana Villella; Jeffrey C. Hall


Hereditas | 2000

Brief Report a Phylogeny of the Drosophilidae Using the Sex‐Behaviour Gene Fruitless

Donald A. Gailey; Sun K. Ho; Saiyou Ohshima; Jim H. Liu; Meraf Eyassu; Michael A. Washington; Daisuke Yamamoto; Terence Davis


Genesis | 2005

GAL4 enhancer trap targeting of the Drosophila sex determination gene fruitless

Anthony J. Dornan; Donald A. Gailey; Stephen F. Goodwin

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Saiyou Ohshima

California State University

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Jane B. Allendorfer

University of Cincinnati Academic Health Center

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Jim H. Liu

California State University

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