Donald D. Albers

Tunica albuginea cyst: Rare testicular mass

A case of a benign tunica albuginea cyst as a possible testicular malignancy is presented.

Pharmacokinetics of metronidazole administered intravenously to male rats

Metronidazole was selectively extracted from rat plasma (91.4%), prostate gland (82.6%) and seminal vesicles (87.1%) using ethyl acetate as the organic solvent. A reverse-phase high performance liquid Chromatographie method was developed allowing the quantitation of metronidazole from these tissues. The pharmacokinetics of metronidazole was studied in male rats following the intravenous administration of metronidazole at a dose of 25 mg/Kg. Higher levels of metronidazole were found in plasma than prostate gland and seminal vesicles during the 8 h time period after i.v. injection. A biphasic phenomenon with a rapid distribution followed by a slower elimination phase was observed from the plasma concentration-time curve. Compartmental analysis based on a two-compartment open model with elimination from the central compartment yielded the following pharmacokinetic parameters: terminal elimination rate constant (β) = 0.0023 min−1; biological half-life (t12,β) = 301 min; apparent volu central compartment (Vc) = 1014 ml/kg; apparent volume of distribution based on the area under plasma concentration-time curve (Vdβ) = 2513 ml/kg; apparent volume of distribution at steady state (Vdss) = 1769 ml/kg. Statistical moment theory wa determine noncompartmental pharmacokinetic parameters. The estimates for mean residence time (MRT), clearance (CL) and apparent volume of distribution (Vdss) were calculated to be 213 min, 5.78 ml min−1 kg−1, and 1231 ml/kg, respectively.

Oil granuloma of the ureter

Several years ago we began to inject mineral oil through a ureteral catheter to facilitate stone extraction. Some success was achieved, particularly with impacted calculi. However, we report 2 cases of mineral oil granuloma of the ureter. We now urge that only water soluble lubricants be used in the ureter to avoid this problem.

Surgical effects of rotation of ureter An experimental study

Abstract In 18 female dogs, right-to-left transureteroureterostomy was performed with rotation of the donor ureter 180 to 360 degrees. There were 9 survivors. It appeared that rotations up to 360 degrees did not produce significantly abnormal physiology. In 7 female dogs, the right ureter was severed from the bladder and reimplanted with rotations from 90 to 720 degrees and all survived. It appeared that rotations of the ureter before reimplantation of from 180 to 270 degrees were not significantly harmful.