Donald D. Layton

Supratentorial pilocytic astrocytomas : a clinicopathologic, prognostic, and flow cytometric study of 51 patients

Background. Supratentorial pilocytic astrocytomas are uncommon tumors, the prognosis and management of which have been controversial.

Multiple Sclerosis in Olmsted and Mower Counties, Minnesota

Recent data regarding both the incidence and prevalence of multiple sclerosis (MS) in Rochester, Minn., are presented. Previous incidence estimates (beginning in 1905) were extended through the period

Preliminary communication--treatment of primary brain tumors recurrent after irradiation with aziridinylbenzoquinone (AZQ;NSC-182986).

Twenty-nine patients with primary brain tumors recurrent or progressive after cerebral irradiation were treated with AZQ. Twenty of the 29 patients had also failed prior chemotherapy. CT scan-documented tumor regressions were noted in 17.2% (5/29) and ranged from 15.0% (3/20) in patients with prior chemotherapy to 22.2 (2/9) in patients without prior chemotherapy. Myelosuppression was the only significant toxicity noted. AZQ is worthy of further studies in patients with primary brain tumors.