Donald G. McQuarrie

Immediate Effects of Intravenous Endotoxin on Serotonin Concentrations and Blood Platelets

Adult mongrel dogs were given a lethal dose of E. Coli endotoxin by rapid intravenous injection. Total serotonin levels in the serum fell rapidly, with the concentration in the portal vein and pulmonary artery significantly exceeding that in the femoral artery within the first minute after injection. Small rises in plasma serotonin were found in some of the animals. These changes were coincident with a sharp fall in the number of circulating platelets, with striking changes in platelet morphology, and with the initial fall in blood pressure.

A physiologic approach to the problems of simultaneous bilateral neck dissection

A number of physiologic derangements have been observed resulting from the management of head and neck cancer with resection and simultaneous bilateral neck dissection. A protocol evolved to minimize morbidity from these complications was used on seventeen patients. Eleven are alive and free of disease and there was no mortality.

Tuberculosis and Carcinoma of the Lung

A comparison has been made between 43 patients with lung cancer and tuberculosis and the total group of 1,164 patients with cancer of the lung. The quantitative clinical characteristics of the two groups studied were not different. However, when various symptoms are evaluated in light of the therapy, age, and time course, a number of useful clinical signs of a coexistent malignancy can be identified. If a patient over 50 has acid-fast bacilli in the sputum, this should not be accepted as a reason to diminish the suspicion of a coexistent malignancy. The patient with tuberculosis of the lung has only a slightly higher likelihood of having restrictive or obstructive lung disease which would contraindicate exploration and resection. Otherwise in this series, effective operative management of lung cancer in the tuberculosis patients resulted in proportionately as many cures with no more risk than in the usual patients with lung cancer.

Effect of Methyl Bis (2-Chlorethyl) Amine Upon Survival of Skin Homografts in Rats and Rabbits.

Summary Intensive administration of methyl bis (2 chlorethyl) amine (Nitrogen mustard) to rats and rabbits in doses sufficient to produce and maintain marked leukopenia did not depress host response mechanisms in a degree sufficient to allow significant prolongation of homograft survival.

The intramandibular sliding myoosseous graft. A simple technique for immediate reconstruction of selected anterior mandibular defects.

The intramandibular sliding myoosseous graft provides a new technique for reestablishment of mandibular continuity. It is well suited for immediate or remote reconstruction of midline or unilateral defects. Close attention to constructing smooth, confluent bone margins reduces the probability of mucosal fenestration. We have found that rigid direct osseous fixation improves the rate and quality of osteosynthesis. The technique is a useful and simple addition to the reconstructive armamentarium.

Scientific paperThe intramandibular sliding myoosseous graft: A simple technique for immediate reconstruction of selected anterior mandibular defects☆

The intramandibular sliding myoosseous graft provides a new technique for reestablishment of mandibular continuity. It is well suited for immediate or remote reconstruction of midline or unilateral defects. Close attention to constructing smooth, confluent bone margins reduces the probability of mucosal fenestration. We have found that rigid direct osseous fixation improves the rate and quality of osteosynthesis. The technique is a useful and simple addition to the reconstructive armamentarium.

The problem of the noninbred animal in tissue transplantation

Summary o 1. Observations between strains of commercially bred nonisologous rats show marked variation in homograft survival between six combinations of three strains. Difference in mean survival of groups of reciprocal interstrain grafts was as great as 15 days. 2. The proportion of successful induction of tolerance to homografts between strains varied, depending on strain combination. 3. The data demonstrate the degree of some variations of experimental error which can arise in using noninbred commercial animals in tissue transplantation studies. 4. Some of the problems in interpretation and design of homograft experiments are discussed.