Donald J. Lulu

Truncal vagotomy and pyloroplasty: Critical evaluation of one hundred cases

Abstract One hundred patients having truncal vagotomy and Heineke-Mikulicz pyloroplasty on the surgical service of a Veterans Administration hospital performing mainly vagotomy and distal antrectomy were carefully analyzed. In a follow-up study ranging from two to thirteen years, an operative mortality rate of 1 per cent and a proved recurrence rate of 2 per cent were found. The factors involved in the choice of operation for duodenal ulcer were reviewed, and in our hospital the following rates were developed: vagotomy and distal antrectomy, 73 per cent; vagotomy and pyloroplasty, 16.4 per cent; vagotomy and gastroenterostomy, 8.5 per cent; partial gastrectomy, 1.6 per cent; and miscellaneous operations, 0.5 per cent.

The effect of vagotomy and pyloroplasty in serotonin-induced gastric ulcerations☆

Abstract The pharmacology and clinical states in which serotonin is implicated, together with the striking similarity of the gastric ulcerations produced in the rat with stress ulcers in the human are reviewed. The performance of vagotomy and pyloroplasty in white Wistar rats prior to the intraperitoneal injection of serotonin (5HT) exerted no protective or ameliorating effect upon the acute gastric ulcers produced.