Dong-Lin Chen

An effective O-demethylation of some C19-diterpenoid alkaloids with HBr-glacial acetic acid.

The aconitine-type alkaloids talatisamine (1), 8,14-diacetyltalatisamine (11), and compound 3, the lycoctonine-type alkaloid deltaline (5), and the 7,17-seco C19-diterpenoid alkaloids 7 and 9 were treated with HBr–glacial acetic acid to give useful O-demethylated derivatives 2, 2, 4, 6, 8, and 10 respectively in good to high yields (49–90%).

Five new norditerpenoid alkaloids from Aconitum sinomontanum.

Abstract From the roots of Aconitum sinomontanum, five new norditerpenoid alkaloids, sinomontanitines A (1) and B (2), sinomontanines A (3), B (4) and C (5), were isolated together with the known alkaloids lappaconitine (6) and ranaconitine (7), The structures of the new alkaloids were determined by spectral analysis.

New C19-Diterpenoid Alkaloids from Aconitum Liljestrandii

Two new C 1 9 -diterpenoid alkaloids, liljestrandinine (1) and N-deethyltalatisamine (2) were isolated from the roots of Aconitum liljestrandii along with five known C 1 9 -diterpenoid alkaloids: chasmaconitine (4), forestine (5), pengshenine B (6), cammaconine (7), and 6-epi-foresticine (8). Structures were established by spectroscopic method including 2D NMR.

Partial synthesis and biological evaluation of bisbenzylisoquinoline alkaloids derivatives: potential modulators of multidrug resistance in cancer

A series of new bisbenzylisoquinoline alkaloids was partially synthesized from tetrandrine and fangchinoline and evaluated for their ability to reverse P-glycoprotein-mediated multidrug resistance (MDR) in cancer cells. All the test compounds increased the intracellular accumulation rate of rhodamine 123 in MDR cells (Bel7402 and HCT8), and most exhibited more potent MDR-reversing activity relative to the reference compound verapamil. Compounds 8, 10, 13, and 14 enhanced intracellular accumulation of doxorubicin in Bel7402 and HCT8 cells.

New diterpenoid alkaloids from the roots of Delphinium tiantaishanense.

Four new diterpenoid alkaloids: tiantaishansine (1), tiantaishannine (2), tiantaishanmine (3), and tiantaishandine (4) have been isolated from the roots of Delphinium tiantaishan. Their structures were elucidated by chemical evidence and spectral analyses, including ESI-MS, HR-EI-MS, 1D- and 2D-NMR.

New C19-diterpenoid alkaloids from Aconitum hemsleyanum var leueanthus and Delphinium potaninii.

A new franchetine-type (leueandine 1) and two new lycoctonine-type [potanisines F (3) and G (5)] C19-diterpenoid alkaloids have been isolated from the roots of Aconitum hemsleyanum var. leueanthus and Delphinium potaninii, respectively, and their structures were established on the basis of spectral data.

A new indole alkaloid from Arundo donax L.

A new indole alkaloid, named donasine, has been isolated from the rhizomes of Arundo donax L. Its structure was determined by X-ray crystallographic analysis and spectral methods. The primary pharmacological test showed that the compound has an action of reducing fever.

New aconitine-type C19-diterpenoid alkaloids from Aconitum hemsleyanium var. circinacum.

Two new aconitine-type C19-diterpenoid alkaloids, hemsleyanines C (1) and D (2), were isolated from the roots ofAconitum hemsleyanium var.circinacum, their structures were deter-mined by the chemical evidence and spectral analyses.

Two new C19-DITERPENOID alkaloids from Aconitum kongboense

Two new C19-diterpenoid alkaloids, kongboentine A (1) and kongboentine B (3), were isolated from the roots of Aconitum kongboense Lauener and their structures were elucidated by spectral data.

Two new C19-diterpenoid alkaloids from Aconitum nagarum var. lasiandrum

Continuous investigations of the roots of Aconitum nagarum var. lasiandrum led to the isolation of two new C₁₉-diterpenoid alkaloids, lasiandrine (1) and lasiandroline (2). Their structures were elucidated on the basis of extensive interpretation of spectroscopic and mass spectrometric data.