Dong-Mei Cui

Synthesis of 2-Cyclohexenone Derivatives via Gold(I)-Catalyzed Hydrative Cyclization of 1,6-Diynes

The gold(I) complex (MeAuPPh3) was found to be a highly effective catalyst for the hydrative cyclization of 1,6-diynes to form the corresponding 3-methyl hex-2-enone derivatives with good to excellent yield. The proposed mechanism is described.

Gold-catalyzed hydroalkoxylation of alkoxyallenes.

We report synthesis of allylic acetals via gold-catalyzed hydroalkoxylation of alkoxyallenes with alcohols containing primary and secondary alcohols in good to excellent yields under mild condition.

Porous copper catalyzed click reaction in water

1,2,3-Triazoles were synthesized in water using a cheaper, simple and easily recyclable heterogeneous porous Cu catalyst via one-pot multi component reaction. The catalyst can be recycled five times without significant loss of its catalytic activity.

Gold-catalyzed oxidation of arylallenes: Synthesis of quinoxalines and benzimidazoles.

Summary A gold-catalyzed oxidation of arylallenes to form α-diketones and aldehydes in good yields is presented. Further directed synthesis of quinoxalines and benzimidazoles, via the condensation of the resulting α-diketones and aldehydes with benzene-1,2-diamine, was achieved in high yields.

Gold-catalyzed intermolecular hydroamination of allenes with sulfonamides

Summary A co-catalyst of (PPh3)AuCl/AgOTf for the intermolecular hydroamination of allenes with sulfonamides is shown. The reaction proceeded smoothly under mild conditions for differently substituted allenes giving N-allylic sulfonamides in good yields with high regioselectivity and E-selectivity.

Ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides

An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazines from alcohols and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated benzyl alcohol containing functionalities such as halogens. Monosubstituted to tetrasubstituted biguanidines also afforded the desired products.

Copper-Catalyzed Synthesis of Substituted 2,4-Diamino-1,3,5-triazines from 1,1-Dibromoalkenes and Biguanides

An efficient copper-catalyzed synthesis of substituted 2,4-diamino-1,3,5-triazines from 1,1-dibromoalkenes and biguanides under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated alkyl-, heterocyclic-, or aryl-substituted 1,1-dibromoalkenes containing functionalities such as nitriles, ethers, and halogens. Monosubstituted to tetrasubstituted biguanidines also afforded the desired products.

Ruthenium-catalyzed synthesis of 1,3,5-triazin-2(1H)-ones and dihydro[1,3,5]triazino[1,2-a]benzimidazoles from alcohols and guanides

An efficient ruthenium-catalyzed synthesis of tri-substituted 1,3,5-triazinones from alcohols and guanylureas under mild conditions has been developed. The scope of both the alcohols and guanylureas in the reaction is demonstrated. This ruthenium-catalyzed ring-forming process can be successfully extended to 2-guanidinobenzimidazoles to afford substituted dihydro[1,3,5]triazino[1,2-a]benzimidazoles.

Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones

We have developed a Pt(COD)Cl2-catalyzed hydrative cyclization of 1,6-diynes leading to the formation of functionalized cyclohexenones in good yields.

NaOH-promoted reaction of 1,1-dihaloalkenes and 1H-azoles: Synthesis of dihetaryl substituted alkenes

An efficient NaOH-promoted synthesis of dihetaryl substituted alkenes from 1,1-dihaloalkenes and 1H-azoles under mild conditions has been developed. The reaction occurred in moderate to good yields and tolerated aliphatic, heterocyclic, and aryl substituted 1,1-dihaloalkenes containing functionalities such as nitriles, ethers, and halogens. Imidazoles and triazoles also afforded the desired products.