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Dive into the research topics where Donghao Chen is active.

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Featured researches published by Donghao Chen.


Pharmaceutical Research | 1999

Formulation and physical characterization of large porous particles for inhalation

Rita Vanbever; Jeffrey Mintzes; Jue Wang; Jacquelyn Nice; Donghao Chen; Richard P. Batycky; Robert Langer; David A. Edwards

AbstractPurpose. Relatively large (>5 µm) and porous (mass density < 0.4 g/cm3) particles present advantages for the delivery of drugs to the lungs, e.g., excellent aerosolization properties. The aim of this study was, first, to formulate such particles with excipients that are either FDA-approved for inhalation or endogenous to the lungs; and second, to compare the aerodynamic size and performance of the particles with theoretical estimates based on bulk powder measurements. Methods. Dry powders were made of water-soluble excipients (e.g., lactose, albumin) combined with water-insoluble material (e.g., lung surfactant), using a standard single-step spray-drying process. Aerosolization properties were assessed with a Spinhaler TM device in vitro in both an Andersen cascade impactor and an AerosizerTM.. Results. By properly choosing excipient concentration and varying the spray drying parameters, a high degree of control was achieved over the physical properties of the dry powders. Mean geometric diameters ranged between 3 and 15 µm, and tap densities between 0.04 and 0.6 g/cm3. Theoretical estimates of mass mean aerodynamic diameter (MMAD) were rationalized and calculated in terms of geometric particle diameters and bulk tap densities. Experimental values of MMAD obtained from the AerosizerTM most closely approximated the theoretical estimates, as compared to those obtained from the Andersen cascade impactor. Particles possessing high porosity and large size, with theoretical estimates of MMAD between 1−3 µm, exhibited emitted doses as high as 96% and respirable fractions ranging up to 49% or 92%, depending on measurement technique. Conclusions. Dry powders engineered as large and light particles, and prepared with combinations of GRAS (generally recognized as safe) excipients, may be broadly applicable to inhalation therapy.


Pharmaceutical Research | 1999

Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs.

Abdellaziz Ben-Jebria; Donghao Chen; Mary Lou Eskew; Rita Vanbever; Robert Langer; David A. Edwards

AbstractPurpose. To determine whether a new formulated albuterol aerosol could sustain inhibition to bronchoconstriction for approximately one day in guinea pigs challenged with carbachol. Methods. Large and porous particles, comprising a combination of endogenous or PDA-approved excipients and albuterol sulfate, were prepared by spray drying using a NIRO portable spray drier. The anesthetized animals inhaled 5 mg of large porous or small nonporous particles by forced ventilation via cannulae inserted in the lumen of their exposed tracheae. At regular intervals over a period of 36 hours after drug delivery, airway resistance was determined in response to carbachol challenge dose. Results. Whereas inhalation of small nonporous albuterol particles protected from the carbachol-induced bronchoconstriction for up to 5 hours, inhalation of large porous albuterol particles produced a significant inhibition of carbachol-induced bronchoconstriction for at least 16 hours. Conclusions. The absence of substantial side effects, verified over a period of 24 hours by evaluating cardio-respiratory parameters as well as pulmonary inflammation, supports the utility of large porous albuterol particles for sustained therapies in asthma and other types of lung disease.


Archive | 2002

Particles for inhalation having rapid release properties

Jennifer L. Schmitke; Donghao Chen; Richard P. Batycky; David A. Edwards; Jeffrey S. Hrkach


Archive | 2004

Control of process humidity to produce large, porous particles

Donghao Chen; Richard P. Batycky; Lloyd Johnston; Jeffrey Mintzes


Archive | 2002

Large, porous particles produced controlling humidity during a spray drying process

Donghao Chen; Richard P. Batycky; Lloyd Johnston; Jeffrey Mintzes


MRS Proceedings | 1998

Production and Characterization of Large Porous Particles for Pulmonary Drug Delivery

Rick Batycky; Jackie Nice; Donghao Chen; Jean Sung; Mike Lipp; Jeff Mintzes; Craig Dunbar; Ralph W. Niven; David A. Edwards


Archive | 2005

Preparation de particules pour inhalation

Donghao Chen; David A. Edwards; Carmen Evora; Justin Hanes; Robert Langer; Jeffrey Mintzes; Rita Vanbever; Jue Wang


Archive | 2005

PREPARACAO DE PARTICULAS PARA INALACAO

Langer Robert S; Hanes Justin; Edwards David A; Carmen Evora; Rita Vanbever; Jeffrey Mintzes; Jue Wang; Donghao Chen


Archive | 2005

Manufacture of particles for pulmonary drug delivery by carbon dioxide assisted nebulization

Blair Jackson; David J. Bennett; Donghao Chen; Michael M. Lipp; Purav Dave


Archive | 2002

large porous particles produced by controlling the humidity during a spray drying.

Richard P. Batycky; Donghao Chen; Lloyd Johnston; Jeffrey Mintzes

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Jeffrey Mintzes

Pennsylvania State University

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Rita Vanbever

Université catholique de Louvain

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Jue Wang

Pennsylvania State University

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Carmen Evora

Massachusetts Institute of Technology

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Lloyd Johnston

Pennsylvania State University

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Robert Langer

Massachusetts Institute of Technology

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Justin Hanes

Johns Hopkins University School of Medicine

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Jeffrey S. Hrkach

Massachusetts Institute of Technology

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