Donghao Chen
Pennsylvania State University
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Featured researches published by Donghao Chen.
Pharmaceutical Research | 1999
Rita Vanbever; Jeffrey Mintzes; Jue Wang; Jacquelyn Nice; Donghao Chen; Richard P. Batycky; Robert Langer; David A. Edwards
AbstractPurpose. Relatively large (>5 µm) and porous (mass density < 0.4 g/cm3) particles present advantages for the delivery of drugs to the lungs, e.g., excellent aerosolization properties. The aim of this study was, first, to formulate such particles with excipients that are either FDA-approved for inhalation or endogenous to the lungs; and second, to compare the aerodynamic size and performance of the particles with theoretical estimates based on bulk powder measurements. Methods. Dry powders were made of water-soluble excipients (e.g., lactose, albumin) combined with water-insoluble material (e.g., lung surfactant), using a standard single-step spray-drying process. Aerosolization properties were assessed with a Spinhaler TM device in vitro in both an Andersen cascade impactor and an AerosizerTM.. Results. By properly choosing excipient concentration and varying the spray drying parameters, a high degree of control was achieved over the physical properties of the dry powders. Mean geometric diameters ranged between 3 and 15 µm, and tap densities between 0.04 and 0.6 g/cm3. Theoretical estimates of mass mean aerodynamic diameter (MMAD) were rationalized and calculated in terms of geometric particle diameters and bulk tap densities. Experimental values of MMAD obtained from the AerosizerTM most closely approximated the theoretical estimates, as compared to those obtained from the Andersen cascade impactor. Particles possessing high porosity and large size, with theoretical estimates of MMAD between 1−3 µm, exhibited emitted doses as high as 96% and respirable fractions ranging up to 49% or 92%, depending on measurement technique. Conclusions. Dry powders engineered as large and light particles, and prepared with combinations of GRAS (generally recognized as safe) excipients, may be broadly applicable to inhalation therapy.
Pharmaceutical Research | 1999
Abdellaziz Ben-Jebria; Donghao Chen; Mary Lou Eskew; Rita Vanbever; Robert Langer; David A. Edwards
AbstractPurpose. To determine whether a new formulated albuterol aerosol could sustain inhibition to bronchoconstriction for approximately one day in guinea pigs challenged with carbachol. Methods. Large and porous particles, comprising a combination of endogenous or PDA-approved excipients and albuterol sulfate, were prepared by spray drying using a NIRO portable spray drier. The anesthetized animals inhaled 5 mg of large porous or small nonporous particles by forced ventilation via cannulae inserted in the lumen of their exposed tracheae. At regular intervals over a period of 36 hours after drug delivery, airway resistance was determined in response to carbachol challenge dose. Results. Whereas inhalation of small nonporous albuterol particles protected from the carbachol-induced bronchoconstriction for up to 5 hours, inhalation of large porous albuterol particles produced a significant inhibition of carbachol-induced bronchoconstriction for at least 16 hours. Conclusions. The absence of substantial side effects, verified over a period of 24 hours by evaluating cardio-respiratory parameters as well as pulmonary inflammation, supports the utility of large porous albuterol particles for sustained therapies in asthma and other types of lung disease.
Archive | 2002
Jennifer L. Schmitke; Donghao Chen; Richard P. Batycky; David A. Edwards; Jeffrey S. Hrkach
Archive | 2004
Donghao Chen; Richard P. Batycky; Lloyd Johnston; Jeffrey Mintzes
Archive | 2002
Donghao Chen; Richard P. Batycky; Lloyd Johnston; Jeffrey Mintzes
MRS Proceedings | 1998
Rick Batycky; Jackie Nice; Donghao Chen; Jean Sung; Mike Lipp; Jeff Mintzes; Craig Dunbar; Ralph W. Niven; David A. Edwards
Archive | 2005
Donghao Chen; David A. Edwards; Carmen Evora; Justin Hanes; Robert Langer; Jeffrey Mintzes; Rita Vanbever; Jue Wang
Archive | 2005
Langer Robert S; Hanes Justin; Edwards David A; Carmen Evora; Rita Vanbever; Jeffrey Mintzes; Jue Wang; Donghao Chen
Archive | 2005
Blair Jackson; David J. Bennett; Donghao Chen; Michael M. Lipp; Purav Dave
Archive | 2002
Richard P. Batycky; Donghao Chen; Lloyd Johnston; Jeffrey Mintzes