Dongheon Yang
Kyungpook National University
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Publication
Featured researches published by Dongheon Yang.
Journal of Cardiac Failure | 2010
Myung-A Kim; Dongheon Yang; Keisuke Kida; Natalia Molotkova; Seon Ju Yeo; Nissi M. Varki; Michikado Iwata; Nancy D. Dalton; Kirk L. Peterson; Wolf-Eberhard Siems; Thomas Walther; Randy T. Cowling; John Kjekshus; Barry H. Greenberg
BACKGROUND There is evidence that angiotensin-converting enzyme 2 (ACE2) is cardioprotective. To assess this in the post-myocardial infarction (MI) heart, we treated adult male Sprague-Dawley rats with either placebo (PL) or C16, a selective ACE2 inhibitor, after permanent coronary artery ligation or sham operation. METHODS AND RESULTS Coronary artery ligation resulting in MI between 25% to 50% of the left ventricular (LV) circumference caused substantial cardiac remodeling. Daily C16 administration from postoperative days 2 to 28 at a dose that inhibited myocardial ACE2 activity was associated with a significant increase in MI size and reduction in LV % fractional shortening. Treatment with C16 did not significantly affect post-MI increases in LV end-diastolic dimension but did inhibit increases in wall thickness and fibrosis in non-infarcted LV. On postoperative day 7, C16 had no significant effect on the increased level of apoptosis in the infarct and border zones nor did it significantly affect capillary density surrounding the MI. It did, however, significantly reduce the number of c-kit(+) cells in the border region. CONCLUSIONS These findings support the notion that ACE2 exerts cardioprotective effects by preserving jeopardized cardiomyocytes in the border zone. The reduction in hypertrophy and fibrosis with C16, however, suggests that ACE2 activity has diverse effects on post-MI remodeling.
Journal of Digital Imaging | 2015
Jungsu Kim; Deoknam Seo; In-Seok Choi; Sora Nam; Yongsu Yoon; Hyunji Kim; Jae Her; Seonggyu Han; Soonmu Kwon; Hunsik Park; Dongheon Yang; Jung-Min Kim
Journal of the American College of Cardiology | 2018
Yoon Jung Park; Jang Hoon Lee; Bo Eun Park; Hong Nyun Kim; Nam Kyun Kim; Se Yong Jang; Myung Hwan Bae; Dongheon Yang; Hun Sik Park; Yongkeun Cho; Shung Chull Chae
The Korean journal of internal medicine | 2007
janghoon Lee; Shung-Chull Chae; Hyunsang Lee; Yongwhi Park; Hyeon-Min Ryu; Soon-Hak Lee; Myung-Hwan Bae; Dongheon Yang; Hun-Sik Park; Yongkeun Cho; Jae-Eun Jun; Wee-Hyun Park
Japanese Circulation Journal-english Edition | 2006
Hyungseop Kim; Jung-Ho Heo; Hyunsang Lee; Hynjae Kang; Juyup Han; Yonwhi Park; Dongheon Yang; Hun-Sik Park; Yongkeun Cho; Shung-Chull Chae; Jae-Eun Jun; Wee-Hyun Park
The Korean journal of internal medicine | 2005
Jae-Kook Shin; Hyeon-Min Ryu; J.H. Lee; Byoung-Jin Chang; Yong-Seop Kwon; Hyunsang Lee; Seung Chul Shin; Hyungseop Kim; Jeong-Ho Heo; Dongheon Yang; Byeong-Cheol Ahn; Hun-Sik Park; Yongkeun Cho; Shung-Chull Chae; Jae-Eun Jun; Wee-Hyun Park
Proceedings of the 31st International Congress on Electrocardiology | 2005
Hyungseop Kim; Jung-Ho Heo; Dongheon Yang; Hun-Sik Park; Yongkeun Cho; Shung-Chull Chae; Jae-Eun Jun; Wee-Hyun Park
The Korean journal of internal medicine | 2004
Byoung-Jin Chang; Hyeon-Min Ryu; J.H. Lee; Jae-Kook Shin; Yong-Seop Kwon; Hyunsang Lee; Seung Chul Shin; Hyungseop Kim; Jeong-Ho Heo; Dongheon Yang; Hun-Sik Park; Yongkeun Cho; Shung-Chull Chae; Jae-Eun Jun; Wee-Hyun Park
The Korean journal of internal medicine | 1998
Lee Ha; Dongheon Yang; Sae-Yong Hong; Jun-Yong Choi; K S Ha
The Korean journal of internal medicine | 1992
Sung-Pyo Hong; Dongheon Yang; Hyunchoon Shin; Sung Kook Kim; Na-Ri Kim; Hyo-Young Kim; Jwa-Seop Shin