Donghong Amy Gao
Boehringer Ingelheim
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Publication
Featured researches published by Donghong Amy Gao.
Bioorganic & Medicinal Chemistry Letters | 2008
Zhaoming Xiong; Donghong Amy Gao; Derek Cogan; Daniel R. Goldberg; Ming-Hong Hao; Neil Moss; Edward Pack; Chris Pargellis; Donna Skow; Thomas Trieselmann; Brian Werneburg; Andre White
Chemistry has been developed to specifically functionalize two structurally similar classes of indole-based MK2 inhibitors at positions prompted by a combination of X-ray crystallographic and computer assisted drug design. A gain in molecular potency was obtained by introducing aminomethyl groups to the lactam rings of 6-arylcarbamoyl-tetrahydro-beta-carbolinone and 6-arylcarbamoyl-dihydropyrazino[1,2-a]indolone MK2 inhibitors. In addition, improvements in molecular potency were achieved by expansion of the lactam from a 6- to 7-membered ring leading to 7-arylcarbamoyl-tetrahydro-[1,4]diazepino[1,2-a]indolones.
Bioorganic & Medicinal Chemistry Letters | 2009
Alexander Heim-Riether; Steven John Taylor; Shuang Liang; Donghong Amy Gao; Zhaoming Xiong; E. Michael August; Brandon Collins; Bennett T. Farmer; Kathleen Haverty; Melissa Hill-Drzewi; Hans-Dieter Junker; S. Mariana Margarit; Neil Moss; Thomas Neumann; John R. Proudfoot; Lana Louise Smith Keenan; Renate Sekul; Qiang Zhang; Jun Li; Neil A. Farrow
Bioorganic & Medicinal Chemistry Letters | 2010
Donghong Amy Gao; Zhaoming Xiong; Alexander Heim-Riether; Laura M Amodeo; E. Michael August; Xianhua Cao; Leonard Ciccarelli; Brandon Collins; Kyle E. Harrington; Kathleen Haverty; Melissa Hill-Drzewi; Xiang Li; Shuang Liang; Steluta Mariana Margarit; Neil Moss; Nelamangala Nagaraja; John R. Proudfoot; Rene Roman; Sabine Schlyer; Lana Louise Smith Keenan; Steven John Taylor; Bernd Wellenzohn; Dieter Wiedenmayer; Jun Li; Neil A. Farrow
Archive | 2003
Donghong Amy Gao; Daniel R. Goldberg; Abdelhakim Hammach; Ming-Hong Hao; Neil Moss; Kevin Chungeng Qian; Gregory P. Roth; Christopher Ronald Sarko; Alan David Swinamer; Zhaoming Xiong; Victor Marc Kamhi
Archive | 2009
Asitha Abeywardane; Bennett T. Farmer; Neil A. Farrow; Donghong Amy Gao; Alexander Heim-Riether; Lana Louise Smith Keenan; Ingo Andreas Mugge; Steven John Taylor; Zhaoming Xiong; Yang Yu; Qiang Zhang
Archive | 2010
Stephen Boyer; Donghong Amy Gao; Xin Guo; Thomas M. Kirrane; Christopher Ronald Sarko; Roger J. Snow; Fariba Soleymanzadeh; Yunlong Zhang
Archive | 2003
Donghong Amy Gao; Daniel R. Goldberg; Abdelhakim Hammach; Ming-Hong Hao; Victor Marc Kamhi; Neil Moss; Kevin Chungeng Qian; Gregory P. Roth; Christopher Ronald Sarko; Alan David Swinamer; Zhaoming Xiong
Archive | 2011
Michael J. Burke; Derek Cogan; Donghong Amy Gao; Alexander Heim-Riether; Eugene R. Hickey; Matthew R. Netherton; Philip Dean Ramsden; David C. Thompson; Zhaoming Xiong
Archive | 2008
Kaka Dey; Donghong Amy Gao; Daniel R. Goldberg; Alexander Heim-Riether; John E. Mangette; Ingo Andreas Mugge; Roger J. Snow; Alan David Swinamer; Jiang-Ping Wu; Zhaoming Xiong; Yu Yang
Archive | 2005
Donghong Amy Gao; Neil Moss; Ji Wang; Jiang-Ping Wu; Lifen Wu; Zhaoming Xiong
