Dongxu Sun
The Energy and Resources Institute
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Featured researches published by Dongxu Sun.
Xenobiotica | 2011
Huijuan Wang; Raymond A. Kim; Dongxu Sun; Yiwen Gao; Hao Wang; Juanli Zhu; Chao Chen
To comprehensively understand the effects of CYP2C19 genetic polymorphisms on inhibition-based drug–drug interactions (DDIs), 18 human CYP2C19 non-synonymous single-nucleotide polymorphic variants and the wild-type isoform (CYP2C19.1A) were expressed in yeast cells. Using a fluorescence-based high-throughput method, the kinetic constants of these variants, as well as the inhibition constants for 10 drugs, were determined. CYP2C19.5B and CYP2C19.6 showed no activity towards CEC (3-cyano-7-ethoxycoumarin) O-deethylation. CYP2C19.8, CYP2C19.9, CYP2C19.10, CYP2C19.16, CYP2C19.19, E122A and A161P* (an allele containing both A161P and I331V) exhibited significantly reduced catalytic activities compared with CYP2C19.1A. The inhibition assay showed that the CYP2C19 genotype significantly affected the in vitro drug inhibition potential. Although the effect on drug inhibition potential is genotype- and inhibitor-dependent, there was an obvious trend: drugs tended to exhibit higher IC50 values (i.e. decreased inhibition potential) towards variants with reduced activity compared with variants with normal activity. This indicated that patients with reduced-function alleles may be less susceptible to CYP2C19-related DDIs. In this study, we provided the first in vitro evidence of CYP2C19 genotype-dependent effects on drug inhibition potential. This work greatly extends our understanding of the functional consequences of CYP2C19 genetic polymorphisms, and thus should prove valuable for CYP2C19 genotype-based therapy.
Journal of Biotechnology | 2005
Brigitte Ganter; Stuart Tugendreich; Cecelia Pearson; Eser Ayanoglu; Susanne Baumhueter; Keith Bostian; Lindsay Brady; Leslie J. Browne; John T. Calvin; Gwo-Jen Day; Naiomi C. Breckenridge; Shane Dunlea; Barrett P. Eynon; L. Mike Furness; Joe Ferng; Mark R. Fielden; Susan Fujimoto; Li Gong; Christopher Hu; Radha Idury; Michael S.B. Judo; Kyle L. Kolaja; May D Lee; Christopher McSorley; James M. Minor; Ramesh V. Nair; Georges Natsoulis; Peter Nguyen; Simone M. Nicholson; Hang Pham
Cancer Research | 2001
Ed Perkins; Dongxu Sun; Allen T. Q. Nguyen; Suzana Tulac; Michelle Francesco; Homa Tavana; Hieu Nguyen; Stuart Tugendreich; Peter Barthmaier; Joe Couto; Elaine Yeh; Silke Thode; Kurt Jarnagin; Ajay N. Jain; David J. Morgans; Teri Melese
Archive | 2002
Teri Melese; Edward L. Perkins; Allen T. Q. Nguyen; Dongxu Sun
Archive | 2000
Bret Benton; Ving J. Lee; Francois Malouin; Patrick K. Martin; Molly B. Schmid; Dongxu Sun
Archive | 2002
Dongxu Sun; Edward L. Perkins; Stuart Tugendreich
Genome Research | 2001
Stuart Tugendreich; Ed Perkins; Joe Couto; Peter Barthmaier; Dongxu Sun; Shawn Tang; Suzana Tulac; Allen T. Q. Nguyen; Elaine Yeh; Amy Mays; Ellen Wallace; Tom Lila; Dave Shivak; Mark Prichard; Laura Andrejka; Raymond Kim; Teri Melese
Archive | 2005
Tomasz Glinka; Keith A. Bostian; Mark Surber; Olga Lomovskaya; Dongxu Sun
Archive | 1996
Bret Benton; Keith Bostian; Molly B. Schmid; Dongxu Sun; Jerry M. Buysse
Archive | 2001
David J. Morgans; Silke Thode; Dongxu Sun