Donna M. Ballantine

PCR‐SSCP ANALYSIS OF THE ANGIOTENSIN II TYPE 1: RECEPTOR GENE IN PATIENTS WITH ALDOSTERONE‐PRODUCING ADENOMAS

1. In patients with primary aldosteronism due to angiotensin‐responsive and andotensin‐unresponsive aldosterone‐producing adenomas, no differences in the coding region of the angiotensin II type 1 (AT1) receptor gene were observed compared to normal subjects in peripheral blood leucocyte DNA.

PCR-SSCP analysis of the p53 gene in tumours of the adrenal gland

1. Mutations of the p53 tumour suppressor gene are relatively common in the aetiology of a wide spectrum of tumour types, both sporadic and familial.

Renin Gene Polymorphism Associated with Aldosterone Responsiveness to the Renin-Angiotensin System in Patients with Aldosterone-Producing Adenomas

1. Aldosterone levels in patients with unilateral aldosterone‐producing adenomas may be responsive or unresponsive to the renin‐angiotensin system, with the former often previously misdiagnosed as bilateral adrenal hyperplasia.

Effect of Positive Family History of Hypertension On the Blood-Pressure and Catecholamine Responses to a 6 Hour Adrenaline Infusion

1. The effects of 6 h infusions of adrenaline (INF‐A) or dextrose (INF‐D) and of post‐infusion cold pressor test (CPT) were compared in normal subjects, with (FH +) and without (FH ‐) a family history of hypertension.

Effects of repeated doses of pseudoephedrine on blood pressure and plasma catecholamines in normal subjects and in patients with phaeochromocytoma

1. Increases in blood pressure (BP) and in plasma noradrenaline concentration (NA) were observed after two doses of a non‐prescription decongestant containing pseudoephedrine (PE) in two of three patients with phaeochromocytoma, before but not after removal of the tumour. The pressor response was terminated by oral phenoxybenzamine, and modified by prior exposure to this drug.

PCR-SSCP analysis of the promoter region of the renin gene in patients with aldosterone-producing adenomas.

Aldosterone‐producing adenomas (APA) of the adrenal gland may be responsive or un‐responsive to the renin‐angiotensin system.

Analysis of the Renin Gene in Patients with Aldosterone-Producing Adenomas by Polymerase Chain-Reaction Single-Stranded Conformational Polymorphisms and Long Polymerase Chain-Reaction

1. Angiotensin‐responsive aldosterone‐producing adenomas (AII‐R‐APA) have increased expression of renin mRNA compared with angiotensin‐unresponsive aldosterone‐producing adenomas (AII‐U‐APA) or normal adrenals.

POTASSIUM, GLUCOSE, INSULIN INTERRELATIONSHIPS DURING ADRENALINE INFUSION IN NORMOTENSIVE AND HYPERTENSIVE HUMANS

1. Significant increases in arterial noradrenaline (NA) of similar magnitude were seen in normotensive (NT) and hypertensive humans (HT) during adrenaline (ADR) infusion.

EVIDENCE FOR PRESYNAPTIC β‐ADRENOCEPTOR STIMULATION 24 HOURS AFTER A 6 HOUR ADRENALINE INFUSION

1. The effects of 6 h infusions of adrenaline (INF‐A) and dextrose (INF‐D) were compared in nine normal subjects.