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Featured researches published by Doris Klingelhoefer.


International Journal of Environmental Research and Public Health | 2013

Smoking and Pregnancy — A Review on the First Major Environmental Risk Factor of the Unborn

Mathias Mund; Frank Louwen; Doris Klingelhoefer; Alexander Gerber

Smoking cigarettes throughout pregnancy is one of the single most important avoidable causes of adverse pregnancy outcomes and it represents the first major environmental risk of the unborn. If compared with other risk factors in the perinatal period, exposure to tobacco smoke is considered to be amongst the most harmful and it is associated with high rates of long and short term morbidity and mortality for mother and child. A variety of adverse pregnancy outcomes are linked with cigarette consumption before and during pregnancy. Maternal prenatal cigarette smoke disturbs the equilibrium among the oxidant and antioxidant system, has negative impact on the genetic and cellular level of both mother and fetus and causes a large quantity of diseases in the unborn child. These smoking-induced damages for the unborn offspring manifest themselves at various times in life and for most only a very limited range of causal treatment exists. Education, support and assistance are of high importance to decrease maternal and fetal morbidity and mortality, as there are few other avoidable factors which influence a child’s health that profoundly throughout its life. It is imperative that smoking control should be seen as a public health priority.


Parasites & Vectors | 2013

Yellow fever disease: density equalizing mapping and gender analysis of international research output

Matthias Bundschuh; David A. Groneberg; Doris Klingelhoefer; Alexander Gerber

BackgroundA number of scientific papers on yellow fever have been published but no broad scientometric analysis on the published research of yellow fever has been reported.The aim of the article based study was to provide an in-depth evaluation of the yellow fever field using large-scale data analysis and employment of bibliometric indicators of production and quantity.MethodsData were retrieved from the Web of Science database (WoS) and analyzed as part of the NewQis platform. Then data were extracted from each file, transferred to databases and visualized as diagrams. Partially by means of density-equalizing mapping makes the findings clear and emphasizes the output of the analysis.ResultsIn the study period from 1900 to 2012 a total of 5,053 yellow fever-associated items were published by 79 countries. The United States (USA) having the highest publication rate at 42% (n = 751) followed by far from Brazil (n = 203), France (n = 149) and the United Kingdom (n = 113). The most productive journals are the “Public Health Reports”, the “American Journal of Tropical Medicine and Hygiene” and the “Journal of Virology”. The gender analysis showed an overall steady increase of female authorship from 1950 to 2011. Brazil is the only country of the five most productive countries with a higher proportion of female scientists.ConclusionsThe present data shows an increase in research productivity over the entire study period, in particular an increase of female scientists. Brazil shows a majority of female authors, a fact that is confirmed by other studies.


Journal of Occupational Medicine and Toxicology | 2011

Ships, ports and particulate air pollution - an analysis of recent studies

Daniel Mueller; Stefanie Uibel; Masaya Takemura; Doris Klingelhoefer; David A. Groneberg

The duration of use is usually significantly longer for marine vessels than for roadside vehicles. Therefore, these vessels are often powered by relatively old engines which may propagate air pollution. Also, the quality of fuel used for marine vessels is usually not comparable to the quality of fuels used in the automotive sector and therefore, port areas may exhibit a high degree of air pollution. In contrast to the multitude of studies that addressed outdoor air pollution due to road traffic, only little is known about ship-related air pollution. Therefore the present article aims to summarize recent studies that address air pollution, i.e. particulate matter exposure, due to marine vessels. It can be stated that the data in this area of research is still largely limited. Especially, knowledge on the different air pollutions in different sea areas is needed.


Journal of Occupational Medicine and Toxicology | 2014

Silicosis: geographic changes in research: an analysis employing density-equalizing mapping

Alexander Gerber; Doris Klingelhoefer; David A. Groneberg; Matthias Bundschuh

BackgroundA critical evaluation of scientific efforts is needed in times of modified evaluation criteria for academic personnel and institutions.MethodsUsing scientometric benchmark procedures and density-equalizing mapping, we analysed the global scientific efforts on “silicosis” of the last 92 years focusing on geographical changes within the last 30 years, specifying the most productive authors, institutions, countries and the most successful cooperations.ResultsThe USA as the most productive supplier have established their position as center of international cooperation, followed in considerable distance by the United Kingdom, Germany and China. Asian countries, particularly China, catch up and are expected to excel the USA still in this decade.ConclusionThe combination of scientometric procedures with density-equalizing mapping reveals a distinct global pattern of research productivity and citation activity. Modified h-index, citationrate and impact factor have to be discussed critically due to distortion by bias of self-citation, language and co-authorship.


BMC Infectious Diseases | 2013

Influenza: a scientometric and density-equalizing analysis

Ralph Fricke; Stefanie Uibel; Doris Klingelhoefer; David A. Groneberg

BackgroundNovel influenza in 2009 caused by H1N1, as well as the seasonal influenza, still are a challenge for the public health sectors worldwide. An increasing number of publications referring to this infectious disease make it difficult to distinguish relevant research output. The current study used scientometric indices for a detailed investigation on influenza related research activity and the method of density equalizing mapping to make the differences of the overall research worldwide obvious. The aim of the study was to compare scientific effort over the time as well as geographical distribution including the cooperation on national and international level.MethodsTherefore, publication data was retrieved from Web of Science (WoS) of Thomson Scientific. Subsequently the data was analysed in order to show geographical distributions and the development of the research output over the time.The query retrieved 51,418 publications that are listed in WoS for the time interval from 1900 to 2009. There is a continuous increase in research output and general citation activity especially since 1990.ResultsThe identified all in all 51,418 publications were published by researchers from 151 different countries. Scientists from the USA participate in more than 37 percent of all publications, followed by researchers from the UK and Germany with more than five percent. In addition, the USA is in the focus of international cooperation.In terms of number of publications on influenza, the Journal of Virology ranks first, followed by Vaccine and Virology. The highest impact factor (IF 2009) in this selection can be established for The Lancet (30.75). Robert Webster seems to be the most prolific author contributing the most publications in the field of influenza.ConclusionsThis study reveals an increasing and wide research interest in influenza. Nevertheless, citation based-declaration of scientific quality should be considered critically due to distortion by self-citation and co-authorship.


International Journal of Environmental Research and Public Health | 2014

Global Research on Smoking and Pregnancy—A Scientometric and Gender Analysis

Mathias Mund; Beatrix Kloft; Matthias Bundschuh; Doris Klingelhoefer; David A. Groneberg; Alexander Gerber

The exposure to tobacco smoke during pregnancy is considered to be amongst the most harmful avoidable risk factors. In this scientometric and gender study scientific data on smoking and pregnancy was analyzed using a variety of objective scientometric methods like the number of scientific contributions, the number of citations and the modified h-index in combination with gender-specific investigations. Covering a time period from 1900 to 2012, publishing activities of 27,955 authors, institutions and countries, reception within the international scientific community and its reactions were analyzed and interpreted. Out of 10,043 publications the highest number of scientific works were published in the USA (35.5%), followed by the UK (9.9%) and Canada (5.3%). These nations also achieve the highest modified h-indices of 128, 79 and 62 and the highest citation rates of 41.4%, 8.6% and 5.3%, respectively. Out of 12,596 scientists 6,935 are female (55.1%), however they account for no more than 49.7% of publications (12,470) and 42.8% of citations (172,733). The highest percentage of female experts about smoking and pregnancy is found in Australasia (60.7%), while the lowest is found in Asia (41.9%). The findings of the study indicate an increase in gender equality as well as in quantity and quality of international scientific research about smoking and pregnancy in the future.


Journal of Viral Hepatitis | 2014

Hepatitis B: global scientific development from a critical point of view

S. Schmidt; Matthias Bundschuh; Cristian Scutaru; Doris Klingelhoefer; David A. Groneberg; Alexander Gerber

Hepatitis B is the tenth leading cause of death worldwide. Countries with high endemicity, such as China and Taiwan show high scientific productivity in this field and dominate the top ten list of the most productive authors worldwide, providing four of them. This is remarkable, as the USA and Europe usually maintain leading positions, not only regarding country‐specific scientific productivity, but also top ten ranking of most productive and most cited authors in other important medical sectors. So far, a scientometric analysis of the topic ‘hepatitis B’ has not been generated despite an increased need for it in times of modified evaluation criteria for academic personnel and a subsequent tendency to co‐authorship and author self‐citation. In this study, scientometric methods and large‐scale data analysis were used to evaluate quality and quantity of scientific research dealing with the topic ‘hepatitis B’ and to contribute to distinguish relevant research output. Data were gained from Pubmed and ISI‐Web. In the time span of 1971–2011, 49 166 items were published by 250 countries, of which the USA have been the most productive supplier with 28% of all publications, followed in considerable distance by Germany, China, the United Kingdom, Japan, France, Italy and Taiwan, respectively. The USA have established their position as centre of international cooperation. Their cooperation with China proves to be the most productive one. The most prolific journals in the field of hepatitis b were ‘Hepatology’, the ‘Journal of Hepatology’ and the ‘Journal of Medical Virology’. h‐index, citation rate and impact factor, commonly used for assessment of scientific quality, were determined and discussed critically with regard to distortion by bias of self‐citation and co‐authorship.


BMC Public Health | 2013

Traffic medicine–related research: a scientometric analysis

Beatrix Groneberg-Kloft; Doris Klingelhoefer; Simona Zitnik; Cristian Scutaru

ObjectiveTraffic crashes and related injuries are important causes of morbidity and mortality and impose insofar an important burden on public health. However, research in this area is often under-funded. The aim of this study was to analyse quantity, evolution and geographic distribution of traffic medicine-related research. This multi-sectorial field covers both transport and health care sectors.DesignA scientometric approach in combination with visualizing density equalizing mapping was used to analyse published data related to the field of traffic medicine between 1900 and 2008 within the “Web of Science” (WoS) database.ResultsIn total, 5,193 traffic medicine-associated items were produced between 1900 and 2008. The United States was found to have the highest research activity with a production of n = 2,330 published items, followed by Germany (n = 298) and Canada (n = 219). Cooperation analyses resulted in a peak of published multilateral cooperations in the year of 2003. The country with the highest multilateral activity was the USA. The average number of cited references per publication varied heavily over the last 20 years with a maximum of 27.67 in 1995 and a minimum of 15.08 in 1998. Also, a further in-depth analysis was performed with a focus solely on public health aspects which revealed similar trends.ConclusionsSummarizing the present data it can be stated traffic medicine-related research productivity grows annually. Also, an active networking between countries is present. The data of the present study may be used by scientific organisations in order to gain detailed information about research activities in this field which is extremely important for public health.


Journal of Occupational Medicine and Toxicology | 2011

Tobacco smoke particles and indoor air quality (ToPIQ) - the protocol of a new study

Daniel Mueller; Stefanie Uibel; Markus Braun; Doris Klingelhoefer; Masaya Takemura; David A. Groneberg

Environmental tobacco smoke (ETS) is a major contributor to indoor air pollution. Since decades it is well documented that ETS can be harmful to human health and causes premature death and disease. In comparison to the huge research on toxicological substances of ETS, less attention was paid on the concentration of indoor ETS-dependent particulate matter (PM). Especially, investigation that focuses on different tobacco products and their concentration of deeply into the airways depositing PM-fractions (PM10, PM2.5 and PM1) must be stated. The tobacco smoke particles and indoor air quality study (ToPIQS) will approach this issue by device supported generation of indoor ETS and simultaneously measurements of PM concentration by laser aerosol spectrometry. Primarily, the ToPIQ study will conduct a field research with focus on PM concentration of different tobacco products and within various microenvironments. It is planned to extend the analysis to basic research on influencing factors of ETS-dependent PM concentration.


Tuberculosis | 2015

Density equalizing mapping of the global tuberculosis research architecture

David A. Groneberg; Esther Weber; Alexander Gerber; Axel Fischer; Doris Klingelhoefer; Doerthe Brueggmann

BACKGROUND Tuberculosis belongs to the lung infectious diseases with the highest impact on global burden of disease. Yet there is no concise scientometric study about tuberculosis research. Therefore, the NewQiS project elected this subject as focus of an in depth analysis to perform density equalizing mapping in combination with scientometrics. METHOD In this retrospective study all publications related to tuberculosis research listed in the Web of Science database between 1900 and 2012 were identified, analyzed and submitted to density equalizing mapping procedures. RESULTS In total 58,319 entries on TBC were identified with the USA being the most productive country with 11,788 publications, followed by the United Kingdom (4202), India (3456), France (2541), South Africa (1840), Germany (1747) and China (1427). Concerning the citations rate Denmark leads with 43.7 citations per article, followed by Latvia (39.1), Gambia (38.3), Senegal (34.9), and the Netherlands (31.4). Chart techniques demonstrates a widely ramified international network with a focus the joint work of USA, the UK and South Africa. CONCLUSIONS This is the first density equalizing and scientometric study that addresses tuberculosis research over a period of 112 years. It illustrates global tuberculosis research architecture and stresses the need for strengthening global research efforts and funding program.

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David A. Groneberg

Goethe University Frankfurt

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Matthias Bundschuh

Goethe University Frankfurt

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Alexander Gerber

Goethe University Frankfurt

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Stefanie Uibel

Goethe University Frankfurt

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Daniel Mueller

Goethe University Frankfurt

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Masaya Takemura

Goethe University Frankfurt

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Simona Zitnik

Goethe University Frankfurt

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Beatrix Kloft

Goethe University Frankfurt

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David Quarcoo

Goethe University Frankfurt

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