Dorothy Wilson

Alterations in Serum Concentration of Vitamin A associated with the Hypoproteinemia of Severe Protein Malnutrition.

Children recovering from kwashiorkor may show an increase in serum vitamin A concentration during the first 1 to 2 weeks of treatment even when receiving a diet based on skim milk free of vitamin A. This occurs only when the liver of the patient initially contains vitamin A reserves. Under these conditions a high correlation is found between serum vitamin A and proteins. Studies in rats with a wide range of serum proteins and albumin, produced by experimental protein deficiency, and/or adrenalectomy, desoxycorticosterone, or cortisone treatments, show a close direct relationship between vitamin A and albumin levels in the serum. The results are evidence of impairment of vitamin A transport in severe protein deficiency.

Serum and Urinary Creatinine in Children with Severe Protein Malnutrition

I N Central Anuenicam as in Jamaica2 and Africa,3 childre suffering from the severe protein dleficiency of kwashiorkor have been found to have a very low urinary output of creatinine. Standlard et al. found that during recovery urinary creatinine increases proportionally to the increase in muscle mass. However, about half of their patiemits and most of ours showedi an abrupt transient rise in creatimime excretion dunimug the first few days of treatmnent, followed by a variable drop, a