Dorottya Kiss

Tracking the physical aging of poly(ethylene oxide): A technical note

Summary and ConclusionsPhysical aging of 2 types of PEO could be tracked by the combination of PALS, DSC, and SEM methods. After storing the samples at 40°C±2°C and 75%±5% RH, a decrease in the o-Ps lifetime values and an increase in the melting enthalpies as a function of storage time indicated a reorientation of the polymer chains. The limitations of monitoring enthalpy relaxation confirm the importance of methods that track volume relaxation, such as PALS. Structural changes could be observed even after a short storage time (4 weeks), which highlights the effect of further investigations of the influence of physical aging on the properties of PEO-containing dosage forms.

Successful Treatment of Lichen Planus with Adalimumab

© 2012 The Authors. doi: 10.2340/00015555-1249 Journal Compilation

Tracking of the kinetic stability of 2 types of total nutrient admixtures containing different lipid emulsions

The physical stability of 2 types of total nutrient admixtures was studied as a function of storage time and temperature. One of them contained only structured triglycerides and the other exclusively long-chain triglycerides as lipid components. To evaluate the possible changes in the kinetic stability of the emulsions and in the surface characteristics of the droplets during storage, particle size analysis, zeta potential, and dynamic surface tension measurements were performed. To follow any chemical decomposition processes that occurred during storage, the pH of the emulsions was also monitored. The mean droplet size of emulsions prepared with lipids containing exclusively long-chain triglycerides showed a remarkable increase after 4 days of storage, in contrast with that of the mixtures containing structured lipids. A combination of size distribution, zeta potential, and dynamic surface tension measurements proved to be useful for an adequate tracking of the kinetic stability of total nutrient admixtures. Structured triglycerides not only provide advantageous metabolic effects but improve the physical stability of total parenteral nutrition admixtures.

Toxic epidermal necrolysis-like lupus erythematosus. Differential diagnostic problems. Report of two cases

A szerzôk toxikus epidermalis necrolysis-szerû lupus erythematosusban szenvedô betegeik kórtörténetét ismertetik és összefoglalják az irodalmi adatokat. A toxikus epidermalis necrolysis-szerû lupus, az acut cutan lupus erythematosus hyperacut formája, melyet az interface dermatitis súlyossága okoz. Klinikailag és szövettanilag nehezen elkülöníthetô a toxikus epidermalis necrolysistôl. A betegek anamnaesisében bôrtünetekkel járó SLE-s aktiváció szerepel, egyértelmû gyógyszerprovokáció nélkül. A bôrtünetek döntôen anularisak, fénylokalizációban, fényexpozíciót követôen jelentkeznek, hetek alatt progrediálnak, ritka a tünetek tenyéri-talpi lokalizációja, a nyálkahártya érintettség hiányzik vagy limitált, a prognózis kedvezôbb. Lupusos betegek hólyagos hámleválással járó tünetei tévesen toxikus epidermalis necrolysisként diagnosztizálhatók, ezért differenciáldiagnosztikai szempontból a kórforma figyelmet érdemel.