Dorsey E. Holtkamp

Gonadotrophin inhibiting and anti-fecundity effects of chloramiphene.

Summary Chloramiphene (1-[p-β-di-ethylaminoethoxy) phenyl] −1, 2-diphenyl-2-chloroethylene) is a pituitary gonadotrophin inhibitor. In immature litter-mate female parabiotic rats (1 castrate: 1 intact), 0.1 mg/ kg/day inhibited ovarian weight gain by 50%. Larger doses yielded greater inhibition.

Side effects of three antihistaminic drugs

Abstract 1.1. A comparison of Benadryl, Pyribenzamine, and Hydryllin was made on the basis of their effect in therapeutic dosage on mental ability, reaction time, two point discrimination distance, pulse rate, blood pressure, and respiratory rate. 2.2. Mental ability, reaction time, and minimum distance of two point discrimination were appreciably altered by these drugs in over one-half the subjects tested. 3.3. Pyribenzamine caused a greater number of individuals to show a decrease in efficiency than did Benadryl, but the latter occasionally caused decreases of considerably greater magnitude. 4.4. Hydryllin caused an increased efficiency in a majority of the subjects but adversely affected a few. 5.5. It is suggested that patients begun on therapy with these antihistaminic drugs be at first kept under strict observation.

Effect of adrenalectomy and adreno-demedullation on experimental edema as measured under repeated ether anesthetizations.

Summary In experimental anti-edema studies, rats were subjected to varying numbers of hind limb volume measurements during a 6-hour period. Edema was induced by sub-plantar injection of mustard. Intact rats having 2 to 5 post-mustard determinations while under light ether anesthesia, had less edema at 6 hours than those having only a single 6-hour measurement. This difference was not observed in similarly anesthetized bilaterally adrenalectomized or bilaterally adreno-demedullated rats, or in unanesthetized intact rats. These results suggest that the adrenal medulla is implicated in the control of experimental inflammatory edema.

Lack of Correlation Between Dietary Level of Manganese and Growth Rate of Induced Fibrosarcomas.

Conclusions At dietary levels of manganese of 1, 11, and 41 mg/rat/day, there is an apparent lack of correlation between level of dietary manganese intake and growth rate of methylcholanthrene-induced sarcomas of the thigh muscles of white rats.