Dou Jingtao
Chinese PLA General Hospital
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Featured researches published by Dou Jingtao.
Advances in Therapy | 2008
Gu Weijun; Lu Juming; Yang Guoqing; Dou Jingtao; Guo Qinghua; Mu Yiming; Pan Chang-yu
IntroductionHomocysteine is a predictor of vascular disease and may have an important role in diabetes. In this study, we examined the effects of folic acid and methylcobalamin supplementation on changes in homocysteine (Hcy) levels and homocysteine thiolactonase/paraoxonase (HTase/PON) activity in a short-term trial.MethodsNinety patients with type 2 diabetes were randomly divided into three groups: Group I received no vitamin supplementation, group II received 5 mg/day folic acid (orally), group III received folic acid (5 mg/day) in combination with methylcobalamin (500 μg/day; intramuscularly, on prescription). All patients were treated for 2 weeks. Plasma Hcy, HTase/PON activity, vitamin B12, and folic acid were measured before and after supplementation in each group. In addition, forty healthy (nondiabetic) controls were enrolled.ResultsSerum HTase/PON activity was significantly higher in diabetics compared with controls, plasma Hcy levels were significantly lower (P<0.05). After vitamin supplementation there was a significant reduction in plasma Hcy levels. The mean percentage reduction in Hcy was 2.75% in group I, 14% in group II and 37.3% in group III. There was a significant inverse correlation between the changes in HTase/PON activity and Hcy levels (r=−0.29, P=0.004). A 2.72% increase in HTase/PON activity was seen in group I, an 8.03% increase was detected when folic acid was given in group II (P<0.001), and a 17.59% increase in HTase/PON activity was seen in group III (P<0.001).ConclusionShort-term oral folic acid (5 mg/day) supplementation with or without methylcobalamin appeared to be an effective approach to decrease Hcy levels and increase HTase/PON activity in patients with type 2 diabetes. A decrease in plasma Hcy levels may partly account for the elevation of serum HTase/PON activity. This could be a novel mechanism to protect against vascular diabetic complications.
The American Journal of the Medical Sciences | 2011
Wang Xianling; Mu Yiming; Dou Jingtao; Zhong Wen-wen; Lu Zhaohui; Lu Juming; Liu Rong
Both ectopic pancreas and insulinoma are rare. A 21-year-old male patient had suffered from hypoglycemia episodes for 3 years and was diagnosed to have insulinoma based on biochemical and endocrinological evaluations. Various localization approaches revealed a distinct tumor outside the pancreas. With intraoperative endoscopy, the tumor in duodenohepatic ligament was identified and successfully resected. Pathologic evaluation revealed an ectopic insulinoma with ectopic pancreas. Therefore, when the biochemically confirmed insulinoma could not be well-definitely localized, the possibility of ectopic insulinoma should be suspected. In addition, radiography examinations and operation exploration should extend to the field where ectopic pancreas usually presents.
Journal of the Renin-Angiotensin-Aldosterone System | 2015
Chen Kang; Li Yijun; Dou Jingtao; Pan Chang-yu; Yan Wenhua; Wang Baoan; Ma Fangling; Wang Xianling; Yang Guoqing; Mu Yiming; Lu Juming
Aim: To investigate the effect of telmisartan on the lipometabolisms and the proinflammatory factors secreted from 3T3-L1 adipocytes and to explore the possible mechanisms. Materials and methods: Telmisartan was applied to interfere with mature 3T3-L1 adipocytes. The culture’s free fatty acids, interleukin 6 (IL-6) and tumor necrosis factor α (TNFα) were evaluated. Oil Red O staining was used to determine the adipogenesis of 3T3-L1 adipocytes. 18F-FDG uptake levels corrected for protein content were determined by cellular radioactivity. The total RNA was isolated for hybridization experimentation in the microarray. Results: Telmisartan reduced lipid storage and increased 18F-FDG uptake in a dose-dependent manner, reduced the levels of IL-6 and TNFα and increased those of free fatty acids. One hundred and fifty-seven differentially expressed genes were found by microarray. The mitogen-activated protein kinase (MAPK) signaling pathway involved in the secretion of proinflammatory factor and lipid metabolisms was affected by telmisartan. The expression of endothelial nitric oxide synthetase gene 3 (Nos3) and carnitine palmitoyl transferase 1α (CPT1α) was up-regulated by telmisartan. Conclusions: Telmisartan affected lipometabolisms and the proinflammatory factors secreted from adipocytes. Nos3, CPT1α and the MAPK pathway being affected by telmisartan may be the underlying cause of the improvement in lipid metabolisms and secretion of proinflammatory factors of differentiated 3T3-L1 adipocytes.
Rheumatology International | 2012
Wang Xianling; Jian-ming Ba; Zhong Wen-wen; Lu Zhaohui; Dou Jingtao; Lu Juming; Mu Yiming
Zhonghua Yixue Zazhi | 2016
Li Lele; Dou Jingtao; Yang Guoqing; Gu Weijun; Lu Zhaohui; Mu Yiming
Zhonghua Yixue Zazhi | 2016
Li Lele; Dou Jingtao; Gu Weijun; Yang Guoqing; Zang Li; Du Jin; Chen Kang; Lv Chaohui; Lu Juming; Mu Yiming
Zhonghua Yixue Zazhi | 2016
Bao Shandan; Pang Ping; Zang Li; Chen Kang; Gu Weijun; Yang Guoqing; Du Jin; Tian Wen; Luo Yukun; Lu Zhaohui; Dou Jingtao; Mu Yiming
Zhonghua Yixue Zazhi | 2016
Gu Yulin; Gu Weijun; Dou Jingtao; Zang Li; Du Jin; Yang Guoqing; Yang Lijuan; Jian-ming Ba; Lv Chaohui; Mu Yiming; Lu Juming
Zhonghua Neifenmi Daixie Zazhi | 2016
Pang Ping; Jia Xiaomeng; Song Yeqiong; Yang Guoqing; Gu Weijun; Zang Li; Du Jin; Jian-ming Ba; Lyu Zhaohui; Dou Jingtao; Mu Yiming
Zhonghua Neifenmi Daixie Zazhi | 2016
Pang Ping; Jia Xiaomeng; Song Yeqiong; Yang Guoqing; Gu Weijun; Zang Li; Du Jin; Jian-ming Ba; Lyu Zhaohui; Dou Jingtao; Mu Yiming