Douglas D. Brunette

Comparison of standard versus high-dose epinephrine in the resuscitation of cardiac arrest in dogs

A prospective, randomized, blinded study was conducted to evaluate the efficacy of standard compared with high-dose epinephrine in cardiac arrest in dogs. Twenty-five mongrel dogs were anesthetized and monitored by central venous catheter, intra-arterial catheter, and ECG. A left lateral thoracotomy was performed, and the proximal left anterior descending artery was ligated. After ten minutes of myocardial ischemia, ventricular fibrillation was obtained by application of 6-V AC. Mechanical ventilation was stopped. Total arrest time was ten minutes. All animals were randomized into one of five resuscitation protocols; each protocol was identical except for the dose and route of epinephrine administration. Group 1 animals comprised the control group and received normal saline. Group 2 and 3 animals received epinephrine in doses of 0.014 mg/kg by central venous and intracardiac injection, respectively. Group 4 and 5 animals received epinephrine in doses of 0.071 mg/kg by central venous and intracardiac injection, respectively. None of the dogs receiving normal saline had a return of spontaneous circulation, defined as a spontaneous systolic blood pressure of more than 50 mm Hg. Nine of the ten animals from groups 2 and 3 and all of the ten animals from groups 4 and 5 had a return of spontaneous circulation. However, animals receiving the standard dose of epinephrine had a significantly longer resuscitation time compared with the high-dose group (P = .05) and required more doses of epinephrine for successful resuscitation than did animals receiving high doses (P less than .02).(ABSTRACT TRUNCATED AT 250 WORDS)

Intravascular access in pediatric cardiac arrest

All cases of patients aged less than 48 months who presented in cardiac arrest to the Hennepin County Medical Centers emergency department (ED) during the years 1984 to 1986 were reviewed retrospectively. The ED record, initial and subsequent chest radiographs, hospital charts, and autopsy reports were analyzed. A total of 33 cases were reviewed. The average patient age was 5 months. The average time needed to establish intravascular access was 7.9 +/- 4.2 minutes. Success rates were 77% for central venous catheterization, 81% for surgical vein cutdown, 83% for intraosseous infusion, and 17% for percutaneous peripheral catheterization. Percutaneous peripheral catheterization, when successful, and bone marrow needle placement were the fastest methods of obtaining intravascular access. There were no major immediate complications, and delayed complications were minimal. Attempts at peripheral intravenous catheter placement should be brief, with rapid progression to intraosseous infusion if peripheral attempts are not successful.

Resuscitation of the morbidly obese patient.

Obesity is a major health care problem in the United States. The body mass index (BMI) is the standard measure of obesity. A BMI >25 kg/m2 is defined as overweight and obesity as a BMI > 30 kg/m2. Recent surveys indicate that 54% of adults, or roughly 97 million people, are overweight. Given the incidence of obesity in the general population, it is likely that EM physicians will be involved in the emergency care of critically ill or injured obese patients. The objective of this article is to present the clinical problems associated with the resuscitation of the critically ill or injured obese patient and their potential solutions.

Correlation of emergency health care use, 911 volume, and jail activity with welfare check distribution

STUDY OBJECTIVES The purpose of this study was to examine the relationship among emergency health care use, 911 call volume, and jail admissions with the timing of the distribution of General Assistance, Aid to Families With Dependent Children, and Minnesota Supplemental Aid welfare checks. DESIGN This was a retrospective study analyzing previously collected census and welfare check distribution data. SETTING The data used in this study were obtained from the Hennepin County Medical Center, the Hennepin County jail and alcoholic receiving center, and Department of Economic Assistance. INTERVENTIONS The daily census for the years 1986 through 1988 in the Hennepin County Medical Center emergency department, ED resuscitation room, pediatric ED, crisis intervention center, urgent care center, and alcoholic receiving center was obtained. The numbers of daily ambulance runs, nonelective hospital admissions, Hennepin County 911 calls, and Hennepin County jail admissions for the same years also were obtained. Means for each day of the month were computed across the 36 months of observation. These data were correlated with the number of days elapsed since the monthly issuance of the General Assistance, Aid to Families With Dependent Children, and Minnesota Supplemental Aid welfare checks. MEASUREMENTS AND MAIN RESULTS There were significant correlations between the number of days after distribution of the checks and the average values of the census of the alcoholic receiving center (r = -.96, P less than .00001), the ED (r = -.80, P less than .0001), ambulance runs (r = -.68, P less than .0001), 911 calls (r = -.45, P = .01), jail admissions (r = -.45, P = .01), nonelective hospital admissions (r = -.44, P = .01), and the crisis intervention center visits (r = -.39, P = .03). CONCLUSIONS The findings suggest that scheduling and staffing practices of various emergency service areas in Hennepin County reflect patient load variation associated with time of welfare check distribution. Systematic variation of time or amount of welfare could lead to improved distribution and reduction of emergency services demand.

Emergency department management of thyrotoxic crisis with esmolol.

A previously healthy 26-year-old woman presented to the emergency department complaining of a severe, throbbing, and bifrontal headache. Initial vital signs were pulse rate, 130 beats/min; blood pressure, 128/50 mm Hg; temperature, 100.1 degrees F. Shortly thereafter the patients pulse and temperature increased to 170 beats/min and 103 degrees F, respectively. Physical examination showed a tremulous, anxious woman in moderate distress who had a diffusely and symmetrically enlarged thyroid gland. A diagnosis of thyrotoxic crisis was made, and appropriate therapy instituted, including the use of an esmolol infusion for control of hypersympathetic activity. A review of the clinical presentation, diagnosis, and management of thyrotoxic crisis is presented.

Cerebral resuscitation after cardiac arrest using hetastarch hemodilution, hyperbaric oxygenation and magnesium ion

This study was done to investigate the effects of hemodilution, hyperbaric oxygenation, and magnesium sulfate on cerebral resuscitation. Sixteen mongrel dogs were anesthetized, and monitored via pulmonary artery catheter, arterial catheter and electrocardiogram. A left lateral thoracotomy was done. Ventricular fibrillation was obtained by application of a 6-volt AC current. Mechanical ventilation was stopped. Total arrest time was 12 min. All dogs were cardiac resuscitated within 6 min using internal massage, ventilation, bicarbonate, epinephrine and internal defibrillation. The animals were then randomized into three groups. Group I represented controls, and were not treated. Group II dogs received normvolemic hemodilution using hetastarch (Hespan) containing magnesium sulfate (2000 mg/l), resulting in a hematocrit of 20%-30%. Group III dogs received the above hemodilution plus compression in a hyperbaric oxygen chamber to 2 atmospheres absolute. Critical care management and hourly neurologic scoring was performed for 7 days by blinded observers. All dogs at the time of death underwent autopsies for gross study. Data analysis revealed no statistical difference among the three groups with respect to survival time, cardiac function or neurologic scoring.

Internal cardiac massage and mediastinal irrigation in hypothermic cardiac arrest

Two unconscious patients with unknown past medical histories were found to be severely hypothermic, with core temperatures of 80.2 degrees F and 86.7 degrees F, respectively. During the course of active internal rewarming, both patients sustained a cardiac arrest. Emergency thoracotomies were immediately done, and internal cardiac massage with warmed mediastinal irrigation was performed. Spontaneous cardiac activity developed in both patients. Within 24 hours after resuscitation, both patients were responsive and following commands.

Use of pneumatic antishock trousers in the management of pediatric pelvic hemorrhage

We applied pediatric pneumatic antishock trousers to five young patients who had severe pelvic fractures with evidence of significant retroperitoneal hemorrhage. The trousers were in place for 24 to 96 hours. Utilization of the trousers resulted in stabilization of vital signs and appeared to have decreased ongoing pelvic hemorrhage. No significant complications were noted. We describe a technique for long-term maintenance of pressure within the pneumatic antishock trousers.

Prehospital and emergency department delivery: A review of eight years experience

We reviewed the medical records of all patients who delivered in the prehospital or emergency department setting from 1980 through 1987 at Hennepin County Medical Center. There were 80 deliveries. Twelve women had no prenatal care; the remaining 68 women had an average of seven prenatal visits. There were seven perinatal infant deaths, and an additional seven infants had morbidity subsequent to delivery. Twenty infants required some degree of resuscitation at the time of delivery, including 19 endotracheal intubations. Complications during delivery were numerous and included nuchal cord, breech presentation, shoulder dystocia, postpartum hemorrhage, pre-eclampsia, prolapsed cord, and meconium staining. Prehospital and ED delivery were associated with a high rate of maternal and infant complications.

Pulmonary embolization of needle fragments resulting from intravenous drug abuse

We present two case reports of central embolization of needle fragments as a complication of intravenous drug abuse. In both cases the needle embolization occurred from a peripheral venous site to the right distal pulmonary vasculature. No attempts at removal were made. No complications developed as a result of these needle emboli.