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Douglas John Jenkins

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Publication

Featured researches published by Douglas John Jenkins.

ACS Medicinal Chemistry Letters | 2010

Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter

Lori Krim Gavrin; Paige Erin Mahaney; Douglas John Jenkins; Lisa M. Nogle; Cheryl A. Mugford; Christine Huselton; Jennifer Leiter; Grace H. Johnston; Jenifer A. Bray; Kevin D. Burroughs; Scott Cosmi; Peter D. Alfinito; Douglas M. Ho; Darlene C. Deecher; Eugene John Trybulski

The potency and selectivity of a series of 1-{(1S)-2-[amino]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol analogues are described. These compounds were prepared to improve in vitro metabolic stability and achieve brain penetration. Compound 13 (WAY-260022, NRI-022) was found to be a potent inhibitor of norepinephrine reuptake and demonstrated excellent selectivity over the serotonin and dopamine transporters. Additionally, 13 exhibited oral efficacy in a rat model of thermoregulatory dysfunction.

Organic Letters | 2006

Regioselective synthesis of substituted pyrroles: efficient palladium-catalyzed cyclization of internal alkynes and 2-amino-3-iodoacrylate derivatives.

Matthew L. Crawley; Igor Goljer; Douglas John Jenkins; John F. Mehlmann; Lisa M. Nogle; Rebecca Dooley; Paige Erin Mahaney

Archive | 2004

Substituted N-heterocycle derivatives and methods of their use

Paige Erin Mahaney; Lori Krim Gavrin; Douglas John Jenkins

Archive | 2006

1- (1h- indol- 1-yl) -3- (methylamino) -1- phenylpropan-2-ol derivatives and related compounds as modulators of the monoamine reuptake for the treatment of vasomotor symptoms (vms)

Paige Erin Mahaney; Gavin David Heffernan; Richard D. Coghlan; Stephen Todd Cohn; Callain Younghee Kim; Douglas John Jenkins; Michael Anthony Marella; Casey Cameron Mccomas; Joseph Peter Sabatucci; Eugene A. Terefenko; Eugene John Trybulski; An Thien Vu; Fei Ye; Puwen Zhang

Archive | 2004

1- 2’ (1, 4’-biperidin-1’-yl)-1- (phenyl) -ethyl cyclohexanol derivatives as monoamine reuptake modulators for the treatment of visomotor symptoms

Paige Erin Mahaney; Lori Danielle Krim; Douglas John Jenkins

Archive | 2009

SUBSTITUTED BENZO[d][1,3]OXAZIN-2(4H)-ONES AND RELATED DERIVATIVES AND THEIR USES FOR MODULATING THE PROGESTERONE RECEPTOR

Thomas J. Commons; Douglas John Jenkins; Eugene John Trybulski; Andrew Fensome

Archive | 2007

AMINOALKYL SUBSTITUTED ARYL SULFAMIDE DERIVATIVES AND METHODS OF THEIR USE

Casey Cameron Mccomas; Stephen Todd Cohn; Matthew L. Crawley; Andrew Fensome; Joel Adam Goldberg; Douglas John Jenkins; Callain Younghee Kim; Paige Erin Mahaney; Charles William Mann; Michael Anthony Marella; David John O'Neill; Joseph Peter Sabatucci; Eugene A. Terefenko; Eugene John Trybulski; An Thien Vu; Richard Page Woodworth; Puwen Zhang

Archive | 2006

1- (1h- indol- 1-yl) -3- (methylamino) -1- phenylpropan-2-ol-derivate und verwandte verbindungen als modulatoren der monoamin-wiederaufnahme zur behandlung von vasomotorischen symptomen (vms)

Paige Erin Mahaney; Gavin David Heffernan; Richard D. Coghlan; Stephen Todd Cohn; Callain Younghee Kim; Douglas John Jenkins; Michael Anthony Marella; Casey Cameron Mccomas; Joseph Peter Sabatucci; Eugene A. Terefenko; Eugene John Trybulski; An Thien Vu; Fei Ye; Puwen Zhang

Archive | 2006

Derives de 1- (1h- indol- 1-yl) -3- (methylamino) -1- phenylpropan-2-ol et composes associes utilises comme modulateurs du recaptage de monoamine pour traiter des symptomes vasomoteurs (vms)

Paige Erin Mahaney; Gavin David Heffernan; Richard D. Coghlan; Stephen Todd Cohn; Callain Younghee Kim; Douglas John Jenkins; Michael Anthony Marella; Casey Cameron Mccomas; Joseph Peter Sabatucci; Eugene A. Terefenko; Eugene John Trybulski; An Thien Vu; Fei Ye; Puwen Zhang

Archive | 2004

Derives de 1- 2’ (1, 4’-biperidin-1’-yl)-1- (phenyl) ethyl cyclohexanol utiles comme modulateurs du recaptage de monoamine dans le traitement des symptomes vasomoteurs

Paige Erin Mahaney; Lori Danielle Krim; Douglas John Jenkins

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Collaboration

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Eugene John Trybulski

American Cyanamid

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Casey Cameron Mccomas

Scripps Research Institute

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Eugene A. Terefenko

Pfizer

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Michael Anthony Marella

Cubist Pharmaceuticals

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Puwen Zhang

Pfizer

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Andrew Fensome

Pfizer

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Lisa M. Nogle

Oregon State University

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Lori Krim Gavrin

Pfizer

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Matthew L. Crawley

Incyte

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Charles William Mann

Princeton University

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