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Dive into the research topics where Dov Kolker is active.

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Featured researches published by Dov Kolker.


Journal of Foot & Ankle Surgery | 2010

The optimized evaluation of diabetic foot infection by dual isotope SPECT/CT imaging protocol.

Sherif Heiba; Dov Kolker; Bharat Mocherla; Karan Kapoor; Manli Jiang; Hongju Son; Balasubramanya Rangaswamy; Lale Kostakoglu; Ina Savitch; Maria DaCosta; Josef Machac

Sequential Tc-99m hydroxymethylene-diphosphonate (HDP) 3-phase bone (BS) and In-111 leukocyte scanning (WBCS) have been frequently used to evaluate the diabetic foot, as nonosteomyelitis BS uptake is repeatedly observed and osteomyelitis (OM) in WBCS is often uncertain without BS correlation. Additionally, both modalities are limited in lesion localization because of low resolution and lack of anatomic details. We investigated a method that combined BS/WBCS, and if needed, WBCS/bone marrow scanning (BMS) using SPECT/CT to accurately diagnose/localize infection in a practical protocol. Blood flow/pool images were obtained followed by WBC reinjection and next day dual isotope (DI) BS/WBCS planar and SPECT/CT. BMS/WBCS SPECT/CT (step 2 DI) was obtained on the following day when images were suspicious for mid/hindfoot OM. Diagnosis accuracy and confidence were judged for the various imaging combinations. Diagnosis was classified as OM, soft tissue infection (STI), both OM/STI, and other/no bony pathology by microbiology/pathology or follow-up. Distinction between various diagnostic categories and overall OM diagnostic accuracy in 213 patients were higher for DI than WBCS or BS alone, and for DI SPECT/CT than DI planar or SPECT only. Diagnostic confidence/lesion site was significantly higher for DI SPECT/CT than other comparative imaging methods. In a group of 97 patients with confirmed microbiologic/pathologic diagnosis, similar results were attained. Step 2 DI SPECT/CT performed in 67 patients further improved diagnostic accuracy/confidence. DI SPECT/CT is a highly accurate modality that considerably improves detection and discrimination of STI and OM while providing precise anatomic localization in the diabetic foot. This combined imaging technique promises to beneficially impact diabetic patient care.


Nuclear Medicine Communications | 2013

Dual-isotope SPECT/CT impact on hospitalized patients with suspected diabetic foot infection: saving limbs, lives, and resources.

Sherif Heiba; Dov Kolker; Ong L; Sharma S; Travis A; Teodorescu; Ellozy S; Lale Kostakoglu; Savitch I; Machac J

BackgroundFoot ulcer with suspected infection is one of the most common reasons for hospitalization and a major factor contributing to morbidity and high healthcare-related expenses among diabetic patients. Many patients will require amputation; however, major amputation is associated with an alarmingly high 5-year mortality rate. In this study, we assess the diagnosis and management of suspected foot infection in diabetic patients using dual-isotope (DI) single-photon emission computed tomography/computed tomography (SPECT/CT) compared with conventional imaging. MethodsThe diagnostic accuracy in and management of 227 patients who had undergone DI SPECT/CT was compared with that of 232 similar patients who had undergone conventional imaging including plain radiography, CT, planar bone scanning, planar indium-111 white blood cell scanning, and MRI. The duration of hospitalization was additionally compared between these two groups of patients after excluding patients with other active comorbidities. ResultsSoft-tissue infection, osteomyelitis with or without soft-tissue infection, and other bony pathologies were more accurately and confidently identified with DI SPECT/CT than with conventional imaging. DI SPECT/CT use was associated with significantly fewer major amputations and more selective bony resection as well as with shorter duration of hospitalization when compared with conventional imaging. ConclusionIn this large population of diabetic patients with suspected foot infection DI SPECT/CT was more accurate in diagnosing and localizing infection compared with conventional imaging. In addition, DI SPECT/CT provided clear guidance and promoted many limb salvage procedures. Of equal importance to health economics, DI SPECT/CT use was associated with considerably reduced length of hospitalization compared with conventional imaging.


Archive | 2008

Ankle and Foot Injuries

Aaron M. Levine; Dov Kolker

The ankle mortise is composed of the medial malleolus (distal tibia), lateral malleolus (distal fibula), and talus. The bones of the foot include the seven tarsal bones (talus, calcaneus, navicular, cuboid, and three cuneiforms); five metatarsal bones; 14 phalanges with each digit having a proximal, middle, and distal phalange (the first toe has only a proximal and distal phalange); and two sesamoid bones located on the plantar aspect of the first metatarsal head. The foot can also be subdivided into three anatomical sections: the forefoot (composed of the metatarsals and phalanges), the midfoot (composed of the cuboid and cuneiforms), and the hindfoot (composed of the talus and calcaneus).


The Journal of Nuclear Medicine | 2008

Can dual isotope SPECT/CT scan be a gold imaging standard for diabetic foot (DF) evaluation?

Sherif Heiba; Dov Kolker; Bhara Mocherla; Balasubramanya Rangaswamy; Lale Kostakoglu; Josef Machac


The Journal of Nuclear Medicine | 2012

Impact of dual isotope SPECT/CT on hospitalized patients with suspected diabetic foot infection: Comparison to conventional imaging

Sherif Heiba; Dov Kolker; Shalini Sharma; Arlene Travis; Victoria Teodorescu; Sharif H. Ellozy; Lale Kostakoglu; Ina Savitch; Josef Machac


The Journal of Nuclear Medicine | 2011

The beneficial influence of dual isotope SPECT/CT use on management of patients with suspected diabetic foot infection

Sherif Heiba; Dov Kolker; Leonard Ong; Shahid Khan; Victoria Teodorescu; Sharif H. Ellozy; Fuad Novruzov; Lale Kostakoglu; Ina Savitch; Josef Machac


Society of Nuclear Medicine Annual Meeting Abstracts | 2010

The continuing management of diabetic foot infection: Impact of follow-up with dual tracer (DT) SPECT/CT

Sherif Heiba; Dov Kolker; Leonard Ong; Shahid Khan; Manli Jiang; Victoria Teodorescu; Sharif H. Ellozy; Lale Kostakoglu; Ina Savitch; Josef Machac


Society of Nuclear Medicine Annual Meeting Abstracts | 2009

Does SPECT/CT use provide incremental value to dual isotope imaging of diabetic foot?

Sherif Heiba; Dov Kolker; Karan Kapoor; Hongju Son; Lale Kostakoglu; Ina Savitch; Maria DaCosta; Josef Machac


Society of Nuclear Medicine Annual Meeting Abstracts | 2008

Accurate fusion of In-111 WBC SPECT/CT and MRI in diabetic foot evaluations using CT/MRI correlation

Karin Knesaurek; Dov Kolker; Sridhar Vatti; Josef Machac; Michael Muzinic; Maria DaCosta; Zhuangyu Zhang; Bharat Mocherla; Heiba Sherif


Society of Nuclear Medicine Annual Meeting Abstracts | 2007

The diagnostic confidence of SPECT & SPECT/CT in Indium-111 leukocyte scintigraphy

Sherif Heiba; Balasubramanya Rangaswamy; Dov Kolker; Lale Kostakoglu; Josef Machac

Collaboration


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Josef Machac

Icahn School of Medicine at Mount Sinai

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Lale Kostakoglu

Icahn School of Medicine at Mount Sinai

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Sherif Heiba

Icahn School of Medicine at Mount Sinai

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Ina Savitch

Icahn School of Medicine at Mount Sinai

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Balasubramanya Rangaswamy

Icahn School of Medicine at Mount Sinai

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Bharat Mocherla

Icahn School of Medicine at Mount Sinai

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Victoria Teodorescu

Icahn School of Medicine at Mount Sinai

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Hongju Son

Icahn School of Medicine at Mount Sinai

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Leonard Ong

Memorial Sloan Kettering Cancer Center

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Manli Jiang

Icahn School of Medicine at Mount Sinai

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