Dragica Soldo-Jureša

Effect of steroids on the frequency of regulatory T cells and expression of FOXP3 in a patient with systemic lupus erythematosus: a two-year follow-up.

Regulatory T cells (Tregs) maintain peripheral tolerance by restricting the activity of nearby immunocytes. The loss of tolerance can induce development of autoimmune diseases, such as systemic lupus erythematosus (SLE). It has previously been shown that SLE patients have lower levels of Tregs than controls. Herein we show that glucocorticoid therapy in a newly diagnosed SLE patient was accompanied with the increase in the percentage of CD4+CD25+Foxp3 T cells to the higher levels than in healthy controls. No effect of the therapy was observed on the percentage of CD4+CD25+ T cells. The observed difference in correlation of the CD4+CD25+ and CD4+CD25+Foxp3+ T cells levels with disease onset in a patient receiving steroids emphasized the importance of critical evaluation of Treg phenotype and their role in the control of SLE.

Akute Schulterschmerzen beidseits als Anfangssymptom einer Ochronose

Ochronosis is a rare genetic metabolic disorder resulting from a constitutional lack of homogentisic acid oxidase and subsequent accumulation of its substrate causing destruction of connective tissues with various systemic abnormalities. Typical musculoskeletal symptoms are arthropathy and low back pain and stiffness. Arthropathy primarily affects knee and hip joints, but shoulders are less frequently involved. We describe a case of ochronosis initially presented as acute bilateral shoulder pain. Review of literature with respect to the etiology, natural course of the disease, differential diagnosis and management was made.ZusammenfassungOchronose ist eine seltene, genetisch bedingte Störung des Metabolismus, die durch den Mangel an Homogentisinsäureoxidase entsteht – mit daraus folgender Anhäufung ihres Substrats, was die Destruktion des Bindegewebes und Störungen verschiedener Systeme verursacht. Arthropathie und Kreuzschmerzen sind typische muskuloskelettale Manifestationen. Von der Arthropathie sind in erster Linie Knie und Hüften betroffen. Selten ist sie in den Schultern manifest. Wir stellen einen Fall von Ochronose dar, dessen Anfangsphase von akuten Schmerzen in beiden Schultern gekennzeichnet war. Die Literatur wurde im Hinblick auf die Ätiologie, den natürlichen Krankheitsverlauf, die Differenzialdiagnose und die Behandlung herangezogen.AbstractOchronosis is a rare genetic metabolic disorder resulting from a constitutional lack of homogentisic acid oxidase and subsequent accumulation of its substrate causing destruction of connective tissues with various systemic abnormalities. Typical musculoskeletal symptoms are arthropathy and low back pain and stiffness. Arthropathy primarily affects knee and hip joints, but shoulders are less frequently involved. We describe a case of ochronosis initially presented as acute bilateral shoulder pain. Review of literature with respect to the etiology, natural course of the disease, differential diagnosis and management was made.

[Acute bilateral shoulder pain as initial presentation of ochronosis: a case report and literature review].

Ochronosis is a rare genetic metabolic disorder resulting from a constitutional lack of homogentisic acid oxidase and subsequent accumulation of its substrate causing destruction of connective tissues with various systemic abnormalities. Typical musculoskeletal symptoms are arthropathy and low back pain and stiffness. Arthropathy primarily affects knee and hip joints, but shoulders are less frequently involved. We describe a case of ochronosis initially presented as acute bilateral shoulder pain. Review of literature with respect to the etiology, natural course of the disease, differential diagnosis and management was made.ZusammenfassungOchronose ist eine seltene, genetisch bedingte Störung des Metabolismus, die durch den Mangel an Homogentisinsäureoxidase entsteht – mit daraus folgender Anhäufung ihres Substrats, was die Destruktion des Bindegewebes und Störungen verschiedener Systeme verursacht. Arthropathie und Kreuzschmerzen sind typische muskuloskelettale Manifestationen. Von der Arthropathie sind in erster Linie Knie und Hüften betroffen. Selten ist sie in den Schultern manifest. Wir stellen einen Fall von Ochronose dar, dessen Anfangsphase von akuten Schmerzen in beiden Schultern gekennzeichnet war. Die Literatur wurde im Hinblick auf die Ätiologie, den natürlichen Krankheitsverlauf, die Differenzialdiagnose und die Behandlung herangezogen.AbstractOchronosis is a rare genetic metabolic disorder resulting from a constitutional lack of homogentisic acid oxidase and subsequent accumulation of its substrate causing destruction of connective tissues with various systemic abnormalities. Typical musculoskeletal symptoms are arthropathy and low back pain and stiffness. Arthropathy primarily affects knee and hip joints, but shoulders are less frequently involved. We describe a case of ochronosis initially presented as acute bilateral shoulder pain. Review of literature with respect to the etiology, natural course of the disease, differential diagnosis and management was made.

Akute Schulterschmerzen beidseits als Anfangssymptom einer Ochronose: Fallbericht und Literaturübersicht

Ochronosis is a rare genetic metabolic disorder resulting from a constitutional lack of homogentisic acid oxidase and subsequent accumulation of its substrate causing destruction of connective tissues with various systemic abnormalities. Typical musculoskeletal symptoms are arthropathy and low back pain and stiffness. Arthropathy primarily affects knee and hip joints, but shoulders are less frequently involved. We describe a case of ochronosis initially presented as acute bilateral shoulder pain. Review of literature with respect to the etiology, natural course of the disease, differential diagnosis and management was made.ZusammenfassungOchronose ist eine seltene, genetisch bedingte Störung des Metabolismus, die durch den Mangel an Homogentisinsäureoxidase entsteht – mit daraus folgender Anhäufung ihres Substrats, was die Destruktion des Bindegewebes und Störungen verschiedener Systeme verursacht. Arthropathie und Kreuzschmerzen sind typische muskuloskelettale Manifestationen. Von der Arthropathie sind in erster Linie Knie und Hüften betroffen. Selten ist sie in den Schultern manifest. Wir stellen einen Fall von Ochronose dar, dessen Anfangsphase von akuten Schmerzen in beiden Schultern gekennzeichnet war. Die Literatur wurde im Hinblick auf die Ätiologie, den natürlichen Krankheitsverlauf, die Differenzialdiagnose und die Behandlung herangezogen.AbstractOchronosis is a rare genetic metabolic disorder resulting from a constitutional lack of homogentisic acid oxidase and subsequent accumulation of its substrate causing destruction of connective tissues with various systemic abnormalities. Typical musculoskeletal symptoms are arthropathy and low back pain and stiffness. Arthropathy primarily affects knee and hip joints, but shoulders are less frequently involved. We describe a case of ochronosis initially presented as acute bilateral shoulder pain. Review of literature with respect to the etiology, natural course of the disease, differential diagnosis and management was made.

Akute Schulterschmerzen beidseits als Anfangssymptom einer Ochronose@@@Acute bilateral shoulder pain as initial presentation of ochronosis: Fallbericht und Literaturübersicht@@@A case report and literature review

Ochronosis is a rare genetic metabolic disorder resulting from a constitutional lack of homogentisic acid oxidase and subsequent accumulation of its substrate causing destruction of connective tissues with various systemic abnormalities. Typical musculoskeletal symptoms are arthropathy and low back pain and stiffness. Arthropathy primarily affects knee and hip joints, but shoulders are less frequently involved. We describe a case of ochronosis initially presented as acute bilateral shoulder pain. Review of literature with respect to the etiology, natural course of the disease, differential diagnosis and management was made.ZusammenfassungOchronose ist eine seltene, genetisch bedingte Störung des Metabolismus, die durch den Mangel an Homogentisinsäureoxidase entsteht – mit daraus folgender Anhäufung ihres Substrats, was die Destruktion des Bindegewebes und Störungen verschiedener Systeme verursacht. Arthropathie und Kreuzschmerzen sind typische muskuloskelettale Manifestationen. Von der Arthropathie sind in erster Linie Knie und Hüften betroffen. Selten ist sie in den Schultern manifest. Wir stellen einen Fall von Ochronose dar, dessen Anfangsphase von akuten Schmerzen in beiden Schultern gekennzeichnet war. Die Literatur wurde im Hinblick auf die Ätiologie, den natürlichen Krankheitsverlauf, die Differenzialdiagnose und die Behandlung herangezogen.AbstractOchronosis is a rare genetic metabolic disorder resulting from a constitutional lack of homogentisic acid oxidase and subsequent accumulation of its substrate causing destruction of connective tissues with various systemic abnormalities. Typical musculoskeletal symptoms are arthropathy and low back pain and stiffness. Arthropathy primarily affects knee and hip joints, but shoulders are less frequently involved. We describe a case of ochronosis initially presented as acute bilateral shoulder pain. Review of literature with respect to the etiology, natural course of the disease, differential diagnosis and management was made.