Dragica Vucelic
University of Belgrade
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Featured researches published by Dragica Vucelic.
British Journal of Haematology | 2010
Luca A. Lotta; Mariagabriella Mariani; Dario Consonni; Ilaria Mancini; Roberta Palla; Alberto Maino; Dragica Vucelic; Michele Pizzuti; Pier Mannuccio Mannucci; Flora Peyvandi
The clinical course of thrombotic thrombocytopenic purpura (TTP) is characterized by recurrent disease episodes in up to 50% of cases. The clinical presentation and severity of different TTP episodes have not been systematically compared. Laboratory and clinical information from 51 patients with recurrent disease, derived from 136 patients with TTP included in the Milan TTP registry (URL: http://www.ttpdatabase.org), were used to compare mortality, symptoms and disease‐related laboratory measurements in different disease episodes. The prevalence of severe neurological symptoms (coma, seizures, and focal neurological defects) was significantly lower in recurrences than in the first episode. Platelet counts and haemoglobin levels at presentation were higher in recurrences than in the first disease episode, and lactate dehydrogenase levels were lower. Also, mortality tended to be lower in the second and third disease episodes than in the first. Recurrences of TTP are generally milder than first episodes. These differences in severity should be taken into account in clinical research on TTP and in patient management.
Thrombosis Research | 2015
Dragica Vucelic; Rada Jesic; Snezana Jovicic; Maja Zivotic; Nikica Grubor; Goran Trajkovic; Ivana Canic; Ivo Elezovic; Aleksandra Antovic
BACKGROUND The Clauss fibrinogen method and thrombin clotting time (TCT) are still routinely used in patients with cirrhosis to define fibrinogen concentration and clotting potential. The thromboelastometric functional fibrinogen FIBTEM assay evaluates the strength of fibrin-based clots in whole blood, providing information on both quantitative deficit and fibrin polymerization disorders. OBJECTIVE To compare these three methods of assessing fibrinogen in patients with cirrhosis of different aetiologies, characterized by impairment in fibrinogen concentration as well as functional aberrance. METHODS Sixty patients with alcoholic and 24 patients with cholestatic cirrhosis were included (Child-Pugh score (CPs)A, n=24; B, n=32; C, n=28). All parameters were compared with those from a control group. Maximum clot firmness (MCF) in the FIBTEM test was assessed in regard to its relevance in detection of qualitative fibrinogen disorders in comparison with results obtained by standard measurement methods, i.e. the Clauss fibrinogen method and TCT. RESULTS With increased cirrhosis severity, fibrinogen and FIBTEM-MCF levels significantly declined (p=0.002), while TCT was significantly prolonged (p=0.002). In all CPs groups, fibrinogen strongly correlated with FIBTEM-MCF (r=0.77, r=0.72, r=0.74; p<0.001), while cross-correlations of other assays were highly variable. The prevalence of decreased FIBTEM-MCF values (<9 mm) was significantly higher in advanced CPs categories (p=0.027), whereby the highest prevalence was detected in patients with CPsC (10/16; 62.5%). Nine of the 16 patients with decreased FIBTEM-MCF values had also decreased fibrinogen levels, while in the remaining 7 patients fibrinogen levels were within the reference range, indicating the possible presence of qualitatively altered fibrinogen that could be detected by FIBTEM-MCF. CONCLUSIONS FIBTEM-MCF may be considered as a reliable alternative to standard plasma fibrinogen measurement in cirrhotic patients, especially in evaluating fibrin polymerization disorders in these patients. Further studies are needed to evaluate the usefulness of this assay in predicting bleeding complications in cirrhotic patients as well as monitoring replacement treatment.
Srpski Arhiv Za Celokupno Lekarstvo | 2013
Dragica Vucelic; Danijela Mikovic; Zoran Rajic; Nebojsa Savic; Zivko Budisin; M Nebojsa Antonijevic; Slobodan Obradovic; Dragana Jevtic; Roberta Palla; Carla Valsecchi; Flora Peyvandi
INTRODUCTION The significance of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motif-13) activity for diagnosis and therapy of thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) is still a controversial issue. OBJECTIVE The aim of this report was to analyze the value of ADAMTS13 measurements in the diagnosis of TTP and HUS. METHODS At presentation, we analyzed patients with idiopathic TTP (n = 18), secondary TTP (n = 4), diarrhea positive HUS (n = 3) and diarrhea negative HUS (n = 3) treated in Belgrade, Serbia from 2004 to 2010. ADAMTS13 activity from acute phase samples was measured using the residual collagen binding activity assay at the Haemophilia and Thrombosis Centre, Milan, Italy. RESULTS There was a significant correlation between reduced ADAMTS13 activity and idiopathic TTP diagnosis (p = 0.000) as well as between lower ADAMTS13 activities and higher reticulocytes (p = 0.017) and lactate dehydrogenase levels (p = 0.027). Significant correlation was also found between higher protease activity and diagnosis of HUS (p = 0.000). There was a statistically significant correlation between higher ADAMTS13 activities and higher platelets count (p = 0.002), blood urea nitrogen (p = 0.000), and creatinine level (p = 0.000). CONCLUSION Severe ADAMTS13 deficiency points at the diagnosis of idiopathic TTP and it is present in the secondary TTP but not in HUS.
Srpski Arhiv Za Celokupno Lekarstvo | 2010
Dragica Vucelic; Predrag Miljic; Nebojsa Antonijevic; Miroslav Milicevic
Acta Chirurgica Iugoslavica | 2007
Dragica Vucelic; B. Nenadic; Pesko P; Milos Bjelovic; Dejan Stojakov; Predrag Sabljak; K. Ebrahimi; S. Dunjic; D. Velickovic; Bratislav Spica
Srpski Arhiv Za Celokupno Lekarstvo | 2012
Dragica Vucelic; Milka Golubović; Milos Bjelovic
Acta Chirurgica Iugoslavica | 2011
Dragica Vucelic; Nebojsa Savic; Dejan Stojakov; Predrag Sabljak; B. Nenadic; Ljubica Tomasevic; Milos Bjelovic; Ebrahimi Keramatollah; Bratislav Spica; Dejan Velickovic; Vladimir Sljukic; Predrag Pesko
Srpski Arhiv Za Celokupno Lekarstvo | 2008
Dragica Vucelic; Predrag Sabljak; Predrag Pesko; Dejan Stojakov; K. Ebrahimi; B. Nenadic; Dragan Pejović; D. Velickovic; Milos Bjelovic
Hematology & Transfusion International Journal | 2015
Dragica Vucelic; Rada Jesic; Maja Zivotic; Snezana Jovicic; Ivana Canic; Ivo Elezovic
Acta Chirurgica Iugoslavica | 2011
Dragica Vucelic; Nebojsa Antonijevic; Danijel Galun; Predrag Bulajic; Dragan Basaric; Miroslav Milicevic