Driss Ouzebla

Glycosylation Reaction via a Mild and Efficient One-Pot Reaction Using Doped Natural Phosphate with Iodine as Catalyst

Several α/β-D-ribonucleosides were synthesized in good yields under mild conditions by N-glycosylations of acetyl 2,3,5-tri-O-benzoyl- β-D-ribofuranose with silylated nucleobases in acetonitrile using NP doped with iodine as catalyst.

A one step synthetic approach to L-pyrimidine nucleosides using Natural Phosphate coated with potassium iodide as catalyst

The one-step synthesis of several alpha-L-arabino and beta-L- xylonucleosides was performed in good yields under mild conditions by N-glycosylation of 1-O-acetyl-L-arabino and -xylofuranose using Vorbruggen type reaction conditions with or without Microwave irradiation.

Natural phosphate doped with KI in HMDS: a mild and efficient reagent for alkylation and glycosylation of nucleobases.

Several d-ribonucleosides are prepared from 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranoside and trimethylsilylated nucleobases under mild conditions by using natural phosphate doped with KI as catalyst.

An economical synthesis of D- and L-pyrimidine arabino- and ribonucleosides.

The one-step synthesis of several β-D/L-arabino- and ribonucleosides was performed in good yields under reflux or microwave-assisted fusion method. A comparison of the two methods showed that better yields were obtained using the reflux conditions.