Duane Davis
Duke University
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Featured researches published by Duane Davis.
Medicine | 1996
Souha S. Kanj; Karen E. Welty-Wolf; John F. Madden; Victor F. Tapson; Maher A. Baz; Duane Davis; John R. Perfect
We reviewed the pattern and incidence of fungal infections in patients undergoing lung and heart-lung transplantation at Duke University Medical Center from September 1992 until August 1995, and present here 9 illustrative cases. Of the 73 lung and heart-lung transplant recipients studied, 59 (81%) had positive fungal cultures at some point after transplantation. The cases presented here illustrate that lung transplant recipients are predisposed to a wide variety of fungal infections. The clinical pattern of these infections ranges from asymptomatic to rapidly progressive fatal disease. In addition to the reactivation of previous fungal infections and recent exposure to new environmental sources, the donor lung itself can be the source of fungal infection, as we showed by using molecular epidemiology techniques. Because of the associated morbidity and mortality, efforts should be directed at investigating prophylactic antifungal regimens in lung transplant recipients. Preliminary reports on the use of itraconazole and aerosolized amphotericin B have been encouraging. Prospective randomized studies are needed to assess the safety and cost effectiveness of different regimens. Fungal infections in patients after lung transplantation can significantly impede recovery and lead to substantial mortality.
Clinical Transplantation | 2017
Michael S. Mulvihill; Brian C. Gulack; Asvin M. Ganapathi; Paul J. Speicher; Brian R. Englum; Sameer A. Hirji; Laurie D. Snyder; Duane Davis; Matthew G. Hartwig
Early research suggests prolonged ischemic time in older donor lungs is associated with decreased survival following lung transplantation. The purpose of this study was to determine whether this association holds in the post‐lung allocation score era.
Transplant International | 2017
Asvin M. Ganapathi; Michael S. Mulvihill; Brian R. Englum; Paul J. Speicher; Brian C. Gulack; Asishana A. Osho; Babatunde A. Yerokun; Laurie R. Snyder; Duane Davis; Matthew G. Hartwig
To maximize the benefit of lung transplantation, the effect of size mismatch on survival in lung transplant recipients with restrictive lung disease (RLD) was examined. All single and bilateral RLD lung transplants from 1987 to 2011 in the United Network for Organ Sharing (UNOS) Database were identified. Donor predicted total lung capacity (pTLC):Recipient pTLC ratio (pTLCr) quantified mismatch. pTLCr was segregated into five strata. A Cox proportional hazards model evaluated the association of pTLCr with mortality hazard. To identify a critical pTLCr, a Cox model using a restricted cubic spline for pTLCr was used. A total of 6656 transplants for RLD were identified. Median pTLCr for single orthotopic lung transplant (SOLT) and bilateral orthotopic lung transplant (BOLT) was 1.0 (0.69–1.47) and 0.98 (0.66–1.45). Examination of pTLCr as a categorical variable revealed that undersizing (pTLCr <0.8) for SOLT and moderate oversizing (pTLCr = 1.1–1.2) for SOLT and BOLT had a harmful survival effect [for SOLT pTLC <0.8: HR 1.711 (95% CI 1.146–2.557), P = 0.01 and for BOLT pTLC 1.1–1.2: HR 1.717 (95% CI 1.112–2.651), P = 0.02]. Spline analysis revealed significant changes in SOLT mortality by variation of pTLCr between 0.8–0.9 and 1.1–1.2. RLD patients undergoing SOLT are susceptible to detriments of an undersized lung. RLD patients undergoing BOLT have higher risk of mortality when pTLCr falls between 1.1 and 1.2.
Chest | 2001
Maher A. Baz; Scott M. Palmer; Edward D. Staples; David G. Greer; Victor F. Tapson; Duane Davis
Journal of Heart and Lung Transplantation | 2014
Duane Davis; Cynthia L. Green; S. Keshavjee; S. Azad; Lianne G. Singer; Kenneth R. McCurry; Marie Budev; Scott M. Palmer
Journal of Heart and Lung Transplantation | 2008
Selim M. Arcasoy; Charles C. Marboe; Shaf Keshavjee; Henry D. Tazelaar; Jessie S. Wilt; Paul Corris; David Weill; Kenneth R. McCurry; Duane Davis; J.G. Golden; M. Strueber; Stuart C. Sweet; P. Jaksch; Marie Budev; Michael S. Mulligan; David Erasmus; Elbert P. Trulock; Martin R. Zamora; I. Mahmood; J. Phillips; J. Prentice; K.C. Fang; G. Berry
Journal of The American College of Surgeons | 2004
James Z. Appel; Angela D. Burnette; Karen Mohler; Bin Li; Matthew G. Hartwig; E. Cantu; Scott M. Palmer; William Parker; Nancy L. Reinsmoen; Duane Davis
Journal of Heart and Lung Transplantation | 2014
Matthew G. Hartwig; Asishana A. Osho; Sameer A. Hirji; Anthony W. Castleberry; Asvin M. Ganapathi; Shu S. Lin; Duane Davis
Journal of Heart and Lung Transplantation | 2014
Duane Davis; S. Azad; William Parker; Cynthia L. Green; S. Keshavjee; Kenneth R. McCurry; Lianne G. Singer; Marie Budev; Scott M. Palmer
Journal of Heart and Lung Transplantation | 2012
S. Reddy; Matthew G. Hartwig; Z.A. Hashmi; Shu S. Lin; Duane Davis