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Dive into the research topics where Duane Davis is active.

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Featured researches published by Duane Davis.


Medicine | 1996

Fungal infections in lung and heart-lung transplant recipients. Report of 9 cases and review of the literature.

Souha S. Kanj; Karen E. Welty-Wolf; John F. Madden; Victor F. Tapson; Maher A. Baz; Duane Davis; John R. Perfect

We reviewed the pattern and incidence of fungal infections in patients undergoing lung and heart-lung transplantation at Duke University Medical Center from September 1992 until August 1995, and present here 9 illustrative cases. Of the 73 lung and heart-lung transplant recipients studied, 59 (81%) had positive fungal cultures at some point after transplantation. The cases presented here illustrate that lung transplant recipients are predisposed to a wide variety of fungal infections. The clinical pattern of these infections ranges from asymptomatic to rapidly progressive fatal disease. In addition to the reactivation of previous fungal infections and recent exposure to new environmental sources, the donor lung itself can be the source of fungal infection, as we showed by using molecular epidemiology techniques. Because of the associated morbidity and mortality, efforts should be directed at investigating prophylactic antifungal regimens in lung transplant recipients. Preliminary reports on the use of itraconazole and aerosolized amphotericin B have been encouraging. Prospective randomized studies are needed to assess the safety and cost effectiveness of different regimens. Fungal infections in patients after lung transplantation can significantly impede recovery and lead to substantial mortality.


Clinical Transplantation | 2017

The association of donor age and survival is independent of ischemic time following deceased donor lung transplantation

Michael S. Mulvihill; Brian C. Gulack; Asvin M. Ganapathi; Paul J. Speicher; Brian R. Englum; Sameer A. Hirji; Laurie D. Snyder; Duane Davis; Matthew G. Hartwig

Early research suggests prolonged ischemic time in older donor lungs is associated with decreased survival following lung transplantation. The purpose of this study was to determine whether this association holds in the post‐lung allocation score era.


Transplant International | 2017

Transplant Size Mismatch in Restrictive Lung Disease

Asvin M. Ganapathi; Michael S. Mulvihill; Brian R. Englum; Paul J. Speicher; Brian C. Gulack; Asishana A. Osho; Babatunde A. Yerokun; Laurie R. Snyder; Duane Davis; Matthew G. Hartwig

To maximize the benefit of lung transplantation, the effect of size mismatch on survival in lung transplant recipients with restrictive lung disease (RLD) was examined. All single and bilateral RLD lung transplants from 1987 to 2011 in the United Network for Organ Sharing (UNOS) Database were identified. Donor predicted total lung capacity (pTLC):Recipient pTLC ratio (pTLCr) quantified mismatch. pTLCr was segregated into five strata. A Cox proportional hazards model evaluated the association of pTLCr with mortality hazard. To identify a critical pTLCr, a Cox model using a restricted cubic spline for pTLCr was used. A total of 6656 transplants for RLD were identified. Median pTLCr for single orthotopic lung transplant (SOLT) and bilateral orthotopic lung transplant (BOLT) was 1.0 (0.69–1.47) and 0.98 (0.66–1.45). Examination of pTLCr as a categorical variable revealed that undersizing (pTLCr <0.8) for SOLT and moderate oversizing (pTLCr = 1.1–1.2) for SOLT and BOLT had a harmful survival effect [for SOLT pTLC <0.8: HR 1.711 (95% CI 1.146–2.557), P = 0.01 and for BOLT pTLC 1.1–1.2: HR 1.717 (95% CI 1.112–2.651), P = 0.02]. Spline analysis revealed significant changes in SOLT mortality by variation of pTLCr between 0.8–0.9 and 1.1–1.2. RLD patients undergoing SOLT are susceptible to detriments of an undersized lung. RLD patients undergoing BOLT have higher risk of mortality when pTLCr falls between 1.1 and 1.2.


Chest | 2001

Lung Transplantation After Long-term Mechanical Ventilation* Results and 1-Year Follow-up

Maher A. Baz; Scott M. Palmer; Edward D. Staples; David G. Greer; Victor F. Tapson; Duane Davis


Journal of Heart and Lung Transplantation | 2014

RESULT (Reflux Surgery in Lung Transplantation) To Determine If Prevention of GERD Related Aspiration By Surgical Fundoplication Improves Lung Allograft Function. Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Duane Davis; Cynthia L. Green; S. Keshavjee; S. Azad; Lianne G. Singer; Kenneth R. McCurry; Marie Budev; Scott M. Palmer


Journal of Heart and Lung Transplantation | 2008

196: Variability in the Pathologic Interpretation of Trans-Bronchial Lung Biopsy after Lung Transplantation. Clinical Implications

Selim M. Arcasoy; Charles C. Marboe; Shaf Keshavjee; Henry D. Tazelaar; Jessie S. Wilt; Paul Corris; David Weill; Kenneth R. McCurry; Duane Davis; J.G. Golden; M. Strueber; Stuart C. Sweet; P. Jaksch; Marie Budev; Michael S. Mulligan; David Erasmus; Elbert P. Trulock; Martin R. Zamora; I. Mahmood; J. Phillips; J. Prentice; K.C. Fang; G. Berry


Journal of The American College of Surgeons | 2004

Role of cellular immunity in GERD-associated bronchiolitis obliterans syndrome

James Z. Appel; Angela D. Burnette; Karen Mohler; Bin Li; Matthew G. Hartwig; E. Cantu; Scott M. Palmer; William Parker; Nancy L. Reinsmoen; Duane Davis


Journal of Heart and Lung Transplantation | 2014

Cryoanalgesia Complements Thoracic Epidural Use Following Lung Transplantation

Matthew G. Hartwig; Asishana A. Osho; Sameer A. Hirji; Anthony W. Castleberry; Asvin M. Ganapathi; Shu S. Lin; Duane Davis


Journal of Heart and Lung Transplantation | 2014

Bile Acid, Not pH Probe or Gastrin Predicts Allograft Function at One Year, From the Prospective RESULT (Reflux Surgery in Lung Transplantation)

Duane Davis; S. Azad; William Parker; Cynthia L. Green; S. Keshavjee; Kenneth R. McCurry; Lianne G. Singer; Marie Budev; Scott M. Palmer


Journal of Heart and Lung Transplantation | 2012

521 Does Pulmonary Hypertension Preclude or Impact Outcomes in Single Lung Transplantations for Pulmonary Fibrosis in the Older Recipients

S. Reddy; Matthew G. Hartwig; Z.A. Hashmi; Shu S. Lin; Duane Davis

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