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Featured researches published by Dusanka Lepej.


Journal of Cystic Fibrosis | 2015

176 Elevation of 90 minutes plasma glucose during oral glucose tolerance testing predicts development of cystic fibrosis related diabetes and lung function decline

A. Kotnik Pirs; Marina Praprotnik; Uros Krivec; Dusanka Lepej; N. Bratina; T. Battelino; N. Bratanic

Objectives Recent studies have shown the effect of cystic fibrosis related diabetes (CFRD) on nutritional status and lung function of patients with CF. The aim of our study was to determine the prevalence of CFRD in Slovenian children with CF and the influence of hyperglycemia on their lung function and nutritional status. Methods Data from all Slovenian children with CF were collected. A diagnosis of CFRD was made based on oral glucose tolerance testing (OGTT) and continuous glucose monitoring. The highest level of blood glucose (BG) and the time during the OGTT were evaluated. Nutritional status and lung function of patients with CFRD were determined and compared to CF patients without CFRD. Results A total of 70 patients with a median age of 10.97 (0.9–22.3) years are managed in our Center. Twelve were diagnosed with CFRD (10 girls and 2 boys; median age 15.97 (9.21–18.59) years. The prevalence of CFRD was 17.1%. In 9 the BG levels >11.1 mmol/l at 90 ; during the OGTT were observed. The median value ob glycosylated hemoglobin (HbA1c) at diagnosis was 6.15 (5.6–6.8)%. The median FEV1 was 62% of predicted value and BMI 18.2 (12.4–21.7) kg/m 2 which is the 21 st percentile for age and gender. In patients with CFRD the median FEV1 was 24% lower compared with the rest of our CF patients while there was no significant difference in their BMI. Conclusions The prevalence of CFRD in our Center is comparable to the published data of CF patients of the same age group. Most of the CFRD patients had the highest BG level at 90 ; during OGTT. CFRD was associated with decline in lung function while it had no significant impact on nutritional status of our patients.


Journal of Cystic Fibrosis | 2013

151 Outbreak of multidrug-resistant Serratia marcescens detections in a paediatric cystic fibrosis (CF) centre

J. Rodman; Marina Praprotnik; M. Aldeco; Dusanka Lepej; M. Ostir; K. Seme; Uros Krivec

Introduction and Aims: Serratia marcescens (Sm) is an opportunistic pathogen in patients with cystic fibrosis (CF). CF patients acquire Sm infection mostly following manipulative airway procedures in hospitals, through patient-to-patient contacts or from the environment. This retrospective review aimed to present a case of an outbreak of Sm detections at a paediatric CF centre. Methods: Respiratory sampling, antibiotic susceptibility testing and antibiotic prescribing guidance were assessed. All isolates of Sm were additionally characterised by pulse field gel electrophoresis (PFGE) to determine the strain relatedness. Results: From April to July 2012 Sm was found in 5 patient’s airways’ samples (mean age 9.8 yrs, range 2−19 yrs, Centre size 63 patients, no Sm detected before). Three patients presented with pulmonary exacerbation and S. aureus, concomitantly. All received eradication therapy with TMP-SMX for 14 days based on antibiotic susceptibility. Treatment was repeated in 2 (40%) patients. Strict patient segregation and hygiene measures were implemented. The isolates of Sm did not differ in phenotypic and antibiotic susceptibility, but PFGE showed that all strains were biologically different, thus excluding cross-infection among patients or acquisition in the hospital. Patients therefore probably acquired Sm in a community-related setting. All patients were Sm free 10 months after first detection. Conclusions: Sm infection is of great concern due to its increasing resistance to antibiotics. Accurate identification is important in defining and managing outbreaks. PFGE can be a useful tool for understanding the molecular epidemiology.


Diabetologia | 2017

Closed-loop glucose control in young people with type 1 diabetes during and after unannounced physical activity: a randomised controlled crossover trial

Klemen Dovc; Maddalena Macedoni; Natasa Bratina; Dusanka Lepej; Revital Nimri; Eran Atlas; Ido Muller; Olga Kordonouri; Thomas Danne; Moshe Phillip; Tadej Battelino


European Respiratory Journal | 2014

Flexible bronchoscopy in children with neuromuscular disease and acute hypoxemic respiratory failure requiring noninvasive ventilation

Uros Krivec; Marina Praprotnik; Dusanka Lepej; Ana Kotnik Pirs; Jelena Berger


Journal of Cystic Fibrosis | 2018

P060 The epidemiology of nontuberculous mycobacteria in a paediatric cystic fibrosis centre

A. Kotnik Pirs; M. Žolnir Dovč; Uros Krivec; Malena Aldeco; Dusanka Lepej; A. Zver; Marina Praprotnik


Journal of Cystic Fibrosis | 2017

142 Characteristics of fungal pathogens detected in patients from a single CF center

Uros Krivec; A. Kotnik Pirs; Marina Praprotnik; Malena Aldeco; Dusanka Lepej; A. Zver; R. Tomazin; T. Matos


Journal of Cystic Fibrosis | 2016

77 Long term effect of chronic Pseudomonas aeruginosa colonization on respiratory and nutritional status of children with cystic fibrosis

A. Kotnik Pirs; Malena Aldeco; Dusanka Lepej; Marina Praprotnik; A. Zver; Uros Krivec


European Respiratory Journal | 2016

End-of-life care decisions in a pediatric respiratory unit

Uros Krivec; Marina Praprotnik; Malena Aldeco; Dusanka Lepej; Ana Kotnik; A. Zver; Tita Butenko; Majda Benedik Dolničar; David Neubauer


European Respiratory Journal | 2016

Home high flow oxygen therapy for chronic lung disease of prematurity

Uros Krivec; Marina Praprotnik; Malena Aldeco; Dusanka Lepej; Ana Kotnik Pirs; Alesandra Zver; Irena Štucin Gantar


European Respiratory Journal | 2015

How dangerous are respiratory tract infections with enterovirus D68

Jasna Rodman; Tita Butenko; Ana Kotnik Pirs; Dusanka Lepej; Marina Praprotnik; Tina Uršič; Miroslav Petrovec; Uros Krivec

Collaboration


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Marina Praprotnik

Boston Children's Hospital

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Uros Krivec

Boston Children's Hospital

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Malena Aldeco

Boston Children's Hospital

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Ana Kotnik Pirs

Boston Children's Hospital

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A. Kotnik Pirs

Boston Children's Hospital

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A. Zver

Boston Children's Hospital

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Tita Butenko

Boston Children's Hospital

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Jasna Rodman

Boston Children's Hospital

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Tina Uršič

University of Ljubljana

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